Gene Information

Name : speK (SpyM3_1205)
Accession : NP_665009.1
Strain : Streptococcus pyogenes MGAS315
Genome accession: NC_004070
Putative virulence/resistance : Virulence
Product : streptococcal pyrogenic exotoxin SpeK - phage associated
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 1231883 - 1232662 bp
Length : 780 bp
Strand : -
Note : best blastp hit: gb|AAL09835.1| (AY050245) SpeL; pyrogenic toxin [temperate phage PhiNIH1.1]; SpeK is the same as SpeL of phage NIH1.1 but differs from SpeL of S. pyogenes MGAS8232

DNA sequence :
ATGAAAAAAAATACCTTGACTTTGTTATTCCTTGTGTGTGTATCGCTTGCTCTATACACTACTGAGAGTGTCTTTTCAGA
TACGTACAATACAAATGATGTTAGAAATCCAAGGAACATATATGCTCCTAGATATGATAAAGACGAAATTTTGGATAATA
GAAGATTAAAAGAAATATATAATAAAGAAATTATTGAAAAAAATAATATATCGATAAATGCCAAACAAGGAACGCAATTG
ATTTTTAATACGGATGAAAATACTACAGTTTGGAATGATAACACTTTTAAGAAAGTCATATCTAGTAATCTTTCTCCTTC
ACAGGAAAGAATGTTTAATGTTGGTGATCATGTGAATATTTTTGCTATAGTAAAGTCATATCATGTTGTATGCAAGGAAC
AATTCAATTATAGTGATGGGGGAATAATAAAAACAAGTGATGTAAAACCAGAAGAAAAAGCAATTTATATTAATATTTTT
GGTGAAAAAGAATTACGAACATTAACAGCTAAAGATAAGATTACCTTTAAAAATAATATTGTAACTCTTCAGGAGATTGA
TGTTAGACTTAGGAAAAGTTTGATGGGGGACAGCAAAATAAAATTGTATGAGTACGATTCTTTGTATAAAAAAGGGTTTT
GGGATATTCATTATAAAGACGGTGGCATTAGACACACCAATTTATTTACTTACCCCGACTATACAGATAATGAAACGATT
GATATGAGTAAAGTTAGTCACTTTGATGTTCACTTAAACGAAGATTTTTCTAAAGATTAG

Protein sequence :
MKKNTLTLLFLVCVSLALYTTESVFSDTYNTNDVRNPRNIYAPRYDKDEILDNRRLKEIYNKEIIEKNNISINAKQGTQL
IFNTDENTTVWNDNTFKKVISSNLSPSQERMFNVGDHVNIFAIVKSYHVVCKEQFNYSDGGIIKTSDVKPEEKAIYINIF
GEKELRTLTAKDKITFKNNIVTLQEIDVRLRKSLMGDSKIKLYEYDSLYKKGFWDIHYKDGGIRHTNLFTYPDYTDNETI
DMSKVSHFDVHLNEDFSKD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
seeL YP_002746964.1 exotoxin L precursor Virulence ¥ÕSeq3 Protein 3e-104 98
seeM YP_002746963.1 exotoxin M precursor Virulence ¥ÕSeq3 Protein 1e-31 43

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
speK NP_665009.1 streptococcal pyrogenic exotoxin SpeK - phage associated VFG0953 Protein 2e-107 100
speK NP_665009.1 streptococcal pyrogenic exotoxin SpeK - phage associated VFG0958 Protein 2e-61 58
speK NP_665009.1 streptococcal pyrogenic exotoxin SpeK - phage associated VFG0957 Protein 7e-34 42