Gene Information

Name : smpB (MW0743)
Accession : NP_645560.1
Strain : Staphylococcus aureus MW2
Genome accession: NC_003923
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 838458 - 838922 bp
Length : 465 bp
Strand : +
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCTAAGAAGAAATCACCAGGTACATTAGCGGAAAATCGTAAAGCAAGACATGATTATAATATTGAAGACACGATTGA
AGCGGGAATCGTATTACAAGGTACAGAAATAAAATCGATTCGCCGAGGTAGTGCTAACCTTAAAGATAGTTACGCGCAAG
TTAAAAACGGTGAAATGTATTTGAATAATATGCATATAGCACCATACGAAGAAGGGAATCGTTTTAATCACGATCCTCTT
CGTTCTCGAAAATTATTATTGCATAAACGTGAAATCATTAAATTGGGTGATCAAACACGTGAAATTGGTTATTCGATTGT
GCCATTAAAGCTTTATTTGAAGCATGGGCATTGTAAAGTATTACTTGGTGTCGCACGAGGTAAGAAAAAATATGATAAAC
GTCAAGCTTTGAAAGAAAAAGCAGTCAAACGAGATGTTGCGCGCGATATGAAAGCCCGTTATTAA

Protein sequence :
MAKKKSPGTLAENRKARHDYNIEDTIEAGIVLQGTEIKSIRRGSANLKDSYAQVKNGEMYLNNMHIAPYEEGNRFNHDPL
RSRKLLLHKREIIKLGDQTREIGYSIVPLKLYLKHGHCKVLLGVARGKKKYDKRQALKEKAVKRDVARDMKARY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 2e-64 100
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 3e-31 50
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 2e-24 44