Gene Information

Name : orfX (MW0024)
Accession : NP_644839.1
Strain : Staphylococcus aureus MW2
Genome accession: NC_003923
Putative virulence/resistance : Unknown
Product : rRNA large subunit methyltransferase
Function : -
COG functional category : S : Function unknown
COG ID : COG1576
EC number : -
Position : 33689 - 34168 bp
Length : 480 bp
Strand : +
Note : SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA

DNA sequence :
ATGAAAATCACCATTTTAGCTGTAGGGAAACTAAAAGAGAAATATTGGAAGCAAGCCATAGCAGAATATGAAAAACGTTT
AGGCCCATACACCAAGATAGACATCATAGAAGTTACAGACGAAAAAGCACCAGAAAATATGAGCGACAAAGAAATCGAGC
AAGTAAAAGAAAAAGAAGGCCAACGAATACTAGCCAAAATCAAACCACAATCCACAGTCATTACATTAGAAATACAAGGA
AAGATGCTATCTTCCGAAGGATTGGCCCAAGAATTGAACCAACGCATGACCCAAGGGCAAAGCGACTTTGTATTCGTCAT
TGGCGGATCAAACGGCCTGCACAAGGACGTCTTACAACGTAGTAACTACGCACTATCATTCAGCAAAATGACATTTCCAC
ATCAAATGATGCGGGTTGTGTTAATTGAACAAGTGTACAGAGCATTTAAGATTATGCGTGGAGAAGCATATCATAAATGA

Protein sequence :
MKITILAVGKLKEKYWKQAIAEYEKRLGPYTKIDIIEVTDEKAPENMSDKEIEQVKEKEGQRILAKIKPQSTVITLEIQG
KMLSSEGLAQELNQRMTQGQSDFVFVIGGSNGLHKDVLQRSNYALSFSKMTFPHQMMRVVLIEQVYRAFKIMRGEAYHK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed BAB72138.1 open reading frame X Not tested Type-IVb SCCmec Protein 8e-72 99
unnamed BAC67575.1 open reading frame X Not tested Type-IVc SCCmec Protein 8e-72 99
orfX AAL26648.1 unknown Not tested SCCcap1 Protein 2e-70 99
unnamed BAA82243.1 orfX Not tested Type-II SCCmec Protein 8e-72 99
orfX BAA86653.1 open reading frame X Not tested Type-I SCCmec Protein 8e-72 99
unnamed BAD24821.1 conserved hypothetical protein orfX Not tested Type-V SCCmec Protein 8e-72 99
unnamed BAB47681.1 open reading frame X Not tested Type-III SCCmec Protein 8e-72 99
unnamed BAG06184.1 conserved hypothetical protein orfX Not tested Type-VII SCCmec Protein 8e-72 99
unnamed BAC53844.1 open reading frame X Not tested SRImec-III and SCCmec-III region Protein 8e-72 99
unnamed BAC57492.1 hypothetical protein Not tested Type-IIIinv SCCmec Protein 8e-72 99
SAR0024 YP_039501.1 rRNA large subunit methyltransferase Not tested Type-II SCCmec Protein 1e-71 99
unnamed BAB72121.1 hypothetical protein Not tested Type-IVa SCCmec Protein 8e-72 99
SAV0024 NP_370548.1 rRNA large subunit methyltransferase Not tested Type-II SCCmec Protein 1e-71 99
orfXhom BAB83497.1 open reading frame X Not tested SCC 12263 Protein 4e-63 92
orfX YP_251938.1 rRNA large subunit methyltransferase Not tested SCCmec Protein 2e-68 92
SE0023 NP_763578.1 rRNA large subunit methyltransferase Not tested SCCpbp4 Protein 7e-68 91
SERP2529 YP_190070.1 rRNA large subunit methyltransferase Not tested Type-II SCCmec Protein 7e-68 91
unnamed ACL99851.1 hypothetical protein Not tested Type-V SCCmec Protein 3e-45 86
SSP0026 YP_300116.1 rRNA large subunit methyltransferase Not tested SCC15305RM Protein 5e-66 86