Gene Information

Name : guaA (CJE1385)
Accession : YP_179372.1
Strain : Campylobacter jejuni RM1221
Genome accession: NC_003912
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1297245 - 1298780 bp
Length : 1536 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAAAAAGCAGATATTTTAGTTTTAGACTTTGGCTCTCAATACACTCAGCTTATAGCAAGACGCTTAAGGGAACAAGG
AGTTTATGCAGAAATTTTACCTTTTAATGTAAGCTTGACTGATATTAAGGCGAAAGAACCAAAAGGTATTATTTTAAGCG
GAGGTCCAGCAAGCGTATATGCAACTGATGCGTATTTTTGCGATAAAGGCATATTTGACTTAAATCTACCTATTCTTGGA
ATTTGTTATGGTATGCAACTCATGGCACATCATTACAAAGCTACAGTAGCACCTGCAGGACATAAAGAATACGGCAAAGC
AAACATAGAAATTAAAAAAGATAACGCTTTGTTTAAAAATCTTCCAAAAAAACAAACCGTTTGGATGAGTCATTCTGATA
AAGTAGAAAATTTACCTCAAGGTTTTGAAGTTTTAGCCACAAGTGAAAATAGCCCTTTTTGTGTTTTTGGAAACGAAGAT
AAGAAATTCTTTGCTCTACAATTTCACCCAGAAGTACAACACAGCGAATTTGGCAAAAATATCTTAAAAAATTTTGCTAA
ATATGCTTGCAATTGTGAAAGTGTTTGGAATATGGGTTCTTTTGCAAAAACTCAAGCAGAAAAAATCCGTGAAGAAGTAG
GCAATGATAAAGTGCTTTGTGCTGTAAGTGGCGGAGTAGATAGTAGCGTAGTTGCTGCACTTTTAGCTAGCGCTATAAAA
GAGCAAGTTATAGTAGTTTTTGTAGATAATGGACTTTTAAGAAGTAGAGAAAAAGAACAAGTTGAATTTATGTTTAAAAA
CACTTTAGGCATCGATCTCATCAGCATTGATGCAAGTGAAATTTTCTTAAGTCGCTTAGCTAATGTCACAGATCCTGAAC
AAAAAAGAAAAATCATAGGAAATACCTTTATAGAAGTTTTTGAAGAAGAAGCAAAAAAACATAAAGATGTAAAATATCTC
GCTCAAGGCACACTTTATACTGATATCATAGAAAGTTCTGTTGTAGGTGCAAGCAAAACCATTAAAAGCCATCATAATGT
AGGGGGCTTACCTGAAAAAATGAATCTTAAACTCATAGAGCCTTTAAAAGAAATTTTTAAAGATGAAGTGCGTGCCTTAG
GACTTGAGCTTGGACTTAGTAAAGAAGTAGTTTATCGTCATCCTTTCCCTGGACCAGGTCTTGCTATACGTATTATGGGA
GAAGTAAATCGCCCTGGCTTAGAACTATTGCGCAAGGCTGATGTAATTTTACTTGAAGAACTTAAAAGTACAGGTTGGTA
TGATAAAACTTGGCAAGCATTTTGCGTACTTTTAAATGTTAAAAGCGTTGGAGTTATGGGGGATAATCGCACTTATGATA
ATGCAGTTTGCATACGCGTTGTAGATGCAAGCGATGGCATGACAGCTACTTTCTCGCATTTACCTTACGAAGTTTTAGAA
AACATAAGTCGCCGTATCATCAATGAAGTAGAAGGTATAAACCGCGTTGTTTATGATATCTCAAGCAAACCACCTGCAAC
CATAGAATGGGAATGA

Protein sequence :
MKKADILVLDFGSQYTQLIARRLREQGVYAEILPFNVSLTDIKAKEPKGIILSGGPASVYATDAYFCDKGIFDLNLPILG
ICYGMQLMAHHYKATVAPAGHKEYGKANIEIKKDNALFKNLPKKQTVWMSHSDKVENLPQGFEVLATSENSPFCVFGNED
KKFFALQFHPEVQHSEFGKNILKNFAKYACNCESVWNMGSFAKTQAEKIREEVGNDKVLCAVSGGVDSSVVAALLASAIK
EQVIVVFVDNGLLRSREKEQVEFMFKNTLGIDLISIDASEIFLSRLANVTDPEQKRKIIGNTFIEVFEEEAKKHKDVKYL
AQGTLYTDIIESSVVGASKTIKSHHNVGGLPEKMNLKLIEPLKEIFKDEVRALGLELGLSKEVVYRHPFPGPGLAIRIMG
EVNRPGLELLRKADVILLEELKSTGWYDKTWQAFCVLLNVKSVGVMGDNRTYDNAVCIRVVDASDGMTATFSHLPYEVLE
NISRRIINEVEGINRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-134 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-134 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 9e-135 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-115 48