Gene Information

Name : guaA (SPO2109)
Accession : YP_167339.1
Strain : Ruegeria pomeroyi DSS-3
Genome accession: NC_003911
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2245651 - 2247210 bp
Length : 1560 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGCCAGACATCCCACGACCGCCTTCTGATCATCGACTTCGGCAGCCAGGTAACGCAGCTGATTGCCCGCCGCCTGCG
CGAGCTGAACGTCTATTGCGAAATCCACCCCTATCAGAATGTCACGATGGACTTCGTGCGCGAAATGGCGCCACGGGCCG
TGATCTTCTCGGGCGGGCCCGACAGCGTCACGCGCGAGGGTTCCCCCCGCGCGCCGCAGGAAATCTTTGACTATGGCGTG
CCGATCCTGGGCATCTGCTATGGCCAGCAGACGATGATGACCCAGCTGGGCGGGCGCGTCGAATCCGGCCACGGCACCGC
CGAATTCGGCCGCGCCTATGTCACCCCCAAGGGCACGCTCGACATTCTCGACGGCTGGTTCACCGACGGCCGCGAACAGG
TCTGGATGAGCCATGGCGACCACGTGGCCGAAATCGCCCCCGGGTTCGAGGTCTACGGTACCTCGCCCGGCGCGCCCTTT
GCCATCACCGCCGACACCAGCCGGCATTTCTACGCGGTTCAGTTCCACCCCGAGGTGCACCACACCCCCAACGGCGCAAA
ACTCTACGAGAATTTCGTGCGTCTGGCGGGATTCAAGGGCGACTGGACCATGGGGGCCTATCGCGAGGAAATGATCCGCA
CGATCCGCGAACAGGTCGGCGACAAAAAGGTCATCTGCGGCCTCTCGGGCGGCGTCGACAGTTCGGTCGCCGCGATCCTC
ATCCACGAGGCGATCGGCGACCAGCTCACCTGCGTCTTTGTCGATCACGGGCTGTTGCGCAAGAACGAGGCGACCGAGGT
CGTCGGCATGTTCCGCGACAATTACAACATCCAGCTCATCCATGCCGACGAATCCGATCTGTTCCTGGGCGAGCTTGACG
GCCAGTCCGACCCCGAGACCAAGCGCAAGATCATCGGCAAGCTCTTCATCGACGTGTTCCAGAAACATGCCGACACCATC
GAGGGCGCCGAATTCCTGGCCCAGGGCACGCTGTATCCCGACGTGATCGAATCGGTTTCCTTCTCGGGCGGCCCCTCGGT
CACCATCAAATCGCACCACAATGTGGGCGGCCTGCCGGAGAAGATGGGCCTGAAACTGGTCGAGCCGCTGCGCGAGCTGT
TCAAGGACGAAGTCCGCGCGCTGGGTCGCGAGCTGGGCCTGCCCCAGTCGTTTATCGGTCGCCACCCCTTCCCTGGACCG
GGCCTGGCCATCCGCTGCCCCGGCGAGATCACCCGCGAAAAGCTGGAGATCCTGCGCGAGGCCGACGCGATCTATATCGA
CCAGATTCGCAAGCACGGGCTCTATGACGAGATCTGGCAGGCCTTTGTCGCCATCCTCCCCGTCCGCACCGTCGGCGTGA
TGGGCGACGGGCGCACCTATGATTACGCCTGCGCCCTGCGCGCGGTGACCTCGGTCGACGGCATGACCGCCGATTATTAC
CCGTTCACCCACGAATTCCTGGGCGAGACCGCCACAAGGATCATCAACGAGGTCAAGGGCATCAACCGCTGCACCTATGA
CATCACCTCGAAACCGCCCGGAACCATCGAGTGGGAGTGA

Protein sequence :
MSQTSHDRLLIIDFGSQVTQLIARRLRELNVYCEIHPYQNVTMDFVREMAPRAVIFSGGPDSVTREGSPRAPQEIFDYGV
PILGICYGQQTMMTQLGGRVESGHGTAEFGRAYVTPKGTLDILDGWFTDGREQVWMSHGDHVAEIAPGFEVYGTSPGAPF
AITADTSRHFYAVQFHPEVHHTPNGAKLYENFVRLAGFKGDWTMGAYREEMIRTIREQVGDKKVICGLSGGVDSSVAAIL
IHEAIGDQLTCVFVDHGLLRKNEATEVVGMFRDNYNIQLIHADESDLFLGELDGQSDPETKRKIIGKLFIDVFQKHADTI
EGAEFLAQGTLYPDVIESVSFSGGPSVTIKSHHNVGGLPEKMGLKLVEPLRELFKDEVRALGRELGLPQSFIGRHPFPGP
GLAIRCPGEITREKLEILREADAIYIDQIRKHGLYDEIWQAFVAILPVRTVGVMGDGRTYDYACALRAVTSVDGMTADYY
PFTHEFLGETATRIINEVKGINRCTYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-128 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-128 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-128 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-112 48