Gene Information

Name : dhbE (BCE_2400)
Accession : NP_978710.1
Strain : Bacillus cereus ATCC 10987
Genome accession: NC_003909
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 6.3.2.-
Position : 2287095 - 2288711 bp
Length : 1617 bp
Strand : +
Note : identified by match to protein family HMM PF00501

DNA sequence : 
ATGCTAACAGGTTATACAAAATGGCCAAAAGAATTTGCTGATCGTTATCGAGAGGAAGGGTGTTGGCTTGGGGAAACATT
TGGCGTGATGTTAAGAGAGCGAGCTGAAAAATATGGCGATCAAATTGCAGTTGTAAGTGGTAATACGCATATTACGTATA
GTGAGCTTGATAAAAAAGTAGATCGATTAGCTTCAGGGCTACTGAATTTAGGAATAAAGCAAGAGGATCGAGTTGTAATC
CAGCTACCTAACGTTATCGAGTTTTTCGAAGTATGTTTTGCGCTATTTCGAATTGGGGCACTTCCTGTTTTTGCATTACC
TTCACATCGAAGCAGTGAAATTAGTTATTTTTGTGAGTTTGGTGAGGCGAGTGCTTACGTTATTTCAGATAAAACTCTCG
GTTTTGATTATCGAAAACTAGCAAGAGAAGTGAAAGAGAAAGTGCCAACTTTACAACATGTAATTGTAGTGGGAGAAGAA
GAAGAATTTGTGAACATAAGTGATTTATATATAGATCCCGTTCCATTACCAGAAGTTCAGCCAAATGATATTGCGTTTCT
CCAATTATCAGGGGGGACAACAGGACTTTCTAAATTAATTCCTCGAACGCATGATGATTATATTTATAGTTTACGTGTTA
GCGCTGAAATTTGTAATTTAAGTGCAAAGAGTGTCTATATGGCCGTTCTTCCAGTAGCACATAATTACCCGATGAGCTCT
CCTGGAACATTTGGAACTTTCTATGCGGGTGGAAAAGTAGTGCTGGCAACTGGAGGTAGTCCAGATGAGGCGTTTGCACT
TATTGAAAAAGAAAAAGTTACGATTACTGCTCTTGTACCGCCATTAGCAATGATATGGCTTGATGCTGCATCTTCACGTA
ATAACGATTTATCGAGTCTAGAGGTGATTCAAGTAGGTGGCGCGAAATTTAGTGCTGAAGTTGCAAAACGTATACGCCCT
ACATTTGGATGTACATTACAGCAAGTATTCGGTATGGCGGAAGGATTAGTGAACTATACAAGATTAGATGATCCTGAAGA
AATTATTATTCATACACAAGGTAGACCAATGTCTGCACTCGATGAAGTACGAGTTGTTGATGAAAATGACAACGATGTAA
AACCTGGCGAAGTAGGTAGTTTATTAACAAGAGGGCCATATACAATTCGTGGTTATTATAAAGCAGAAGAGCATAATGCA
CAATCGTTTACAAAGGATGGATTTTATCGCACAGGAGATCTTGTGAAAGTAAATGAACAAGGTTACATCATTGTAGAAGG
AAGAGATAAAGATCAAATTAATCGTGGCGGTGAGAAAGTTGCCGCGGAAGAAGTTGAAAATCATCTATTAGCACATGATG
CAGTACATGATGTAGCGATTGTATCTATGCCTGACGATTATTTAGGAGAACGTACTTGTGCATTTGTTATAGCTCGCGGA
CAAGCTCCGGCAGTAAGTGAATTAAAAATGTTTTTAAGAGAACGCGGTATAGCAGCTTATAAGATTCCAGATCGAATTGA
ATTTATTGAATCATTCCCACAAACAGGCGTTGGAAAGATAAGCAAAAAAGAATTACGTAAAGTCATTGCTGAAAAACTTA
TTACAGTAAAACAATAA

Protein sequence : 
MLTGYTKWPKEFADRYREEGCWLGETFGVMLRERAEKYGDQIAVVSGNTHITYSELDKKVDRLASGLLNLGIKQEDRVVI
QLPNVIEFFEVCFALFRIGALPVFALPSHRSSEISYFCEFGEASAYVISDKTLGFDYRKLAREVKEKVPTLQHVIVVGEE
EEFVNISDLYIDPVPLPEVQPNDIAFLQLSGGTTGLSKLIPRTHDDYIYSLRVSAEICNLSAKSVYMAVLPVAHNYPMSS
PGTFGTFYAGGKVVLATGGSPDEAFALIEKEKVTITALVPPLAMIWLDAASSRNNDLSSLEVIQVGGAKFSAEVAKRIRP
TFGCTLQQVFGMAEGLVNYTRLDDPEEIIIHTQGRPMSALDEVRVVDENDNDVKPGEVGSLLTRGPYTIRGYYKAEEHNA
QSFTKDGFYRTGDLVKVNEQGYIIVEGRDKDQINRGGEKVAAEEVENHLLAHDAVHDVAIVSMPDDYLGERTCAFVIARG
QAPAVSELKMFLRERGIAAYKIPDRIEFIESFPQTGVGKISKKELRKVIAEKLITVKQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-120 51
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-120 51
ybtE CAA21394.1 - Virulence HPI Protein 8e-120 51
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-120 51
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 6e-120 51
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-120 51
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-119 51
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-120 51
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 8e-120 51

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
dhbE NP_978710.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 1e-136 53
dhbE NP_978710.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 4e-112 47
dhbE NP_978710.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 2e-111 45