Gene Information

Name : MM_2976 (MM_2976)
Accession : NP_635000.1
Strain : Methanosarcina mazei Go1
Genome accession: NC_003901
Putative virulence/resistance : Virulence
Product : type I restriction-modification system restriction subunit
Function : -
COG functional category : V : Defense mechanisms
COG ID : COG0610
EC number : 3.1.21.3
Position : 3593860 - 3596853 bp
Length : 2994 bp
Strand : -
Note : -

DNA sequence :
ATGACAACCGATACCACCGAAAAGGGCCTCGAAACCCTCATTGTCGAAGCGATGACAGGAACGAAACCCGACCCTGCGCA
AACAGACATGGGCAGAGAACCGAGTGCACTTTACGGTGTTACCGGCTGGATACTCGGGCGCTGGCAGGACTACGACCGCG
AATATGCTGTTGACCTCGTGCAGCTGACCGAGTTCCTCAAATCCACACAGCCTGAGGTCGCTGAATCCCTTGACCTCGAA
AATGCCAGCCCCACCCGCCAGAAATTTCTCGCCCGCCTGCAGGGAGAGGTTGCAAAGCGCGGGATAATCGAAGTGCTTAG
GAACGGCCTAAAACACGGAAAATACGACATCGACCTCTTTTACGGCACGCCAACGCCTGGAAACACAAAAGCTGAGGAAC
GCTATGCTTTGAACCGCTTCAGCGTTACAAGGCAGCTCCGCTACAGCCGGGGCGAAACACAACTTGCACTCGACCTCTGC
CTTTTCATAAACGGTTTGCCGGTAGCTACTTTTGAACTCAAGAACAGCCTCACAAAACAGACCGTGGAAGACGCTGTGGA
ACAGTATAAAAGAGACCGTGACTCTCGTGAGCTGCTGTTCCAGTTCGGGCGCTGCATGGTCCATTTTGCTGTGGACGACC
ATGAGGTGAAGTTCTGCACGCAGCTTAACGGCAAAAATTCCTGGTTTCTGCCCTTCAACCAGGGCTACAACGACGGTACA
GGCAACCCTCCTAACCCTGCCGGCATCAAGACTGACTATCTCTGGAAGAAAATCCTCACCCCTCAGGGGCTTACCGACAT
CCTTGAAAATTATGCTCAGGTAGTGGAAGAAAAGGACGAAAAGACCGGGAAAAAGAAAAAAGTGCAGATTTTCCCTCGCT
ATCACCAGTTAGACGTTGTTCGGAAACTGCTCGCCCATGCAGAATGGCACGGTGCAGGCATGCGCTACCTGGTACAACAC
TCGGCAGGGAGCGGGAAGAGTAATTCCATTGCGTGGCTTGCTCACCAGCTTATCAGCCTCAAGAAAGACGATAAGGAAAT
CTTTGACTCCATAATCGTAATCACTGACAGGCGCGTCCTTGACAAACAGATCCGCGACACAATCAAGCAGTTTGCCCAGG
TGGGCTCGACAGTCGGGCATGCCGAACGTTCAGGAGACCTGCGGAAGTTCATCGAGAGCGGAAAGAAGATAATCATCTCC
ACGGTCCAGAAATTCCCGTTCATTCTTGATGAGATCGGAAACGAGCACCGCGGTCGGAAATTTGCAATTATCATAGATGA
GGCTCATTCCAGCCAGGGCGGGCGCACAGCAGCAGCCATGAGTGAGGCGCTTTCAGATTCGAAAGACCAGAAAGATCCTG
AAGATACTATCAACGATGCACTGCAAAAGAGGATGGAAGCCCGTAAAATGCTTCCCAACGCCAGCTACTTCGCATTTACC
GCAACTCCGAAAAACAAAACACTGGAGCTTTTCGGGGAACCGTACAAAGATGGAGATAAGATAAAGCACCGGCCTTTCCA
CAATTACACCATGAAGCAGGCTATTCAGGAAGGTTTCATTCTGGACGTGCTCAGGTATTACACACCTGTAAACAGCTATT
ACAAACTGATCAAGACGGTGGAAAGTGACCCAGAGTTTGATACCAAAAAAGCAAAAAAGAAGCTTCGAAAGTACGTCGAG
AGCCACGATTACGCCATCCGGCTCAAGGCTGAAATTATAGTAGACCACTTCCAGGAACAGGTGATCGCTCTCAACAAGAT
AGGAGGACAGGCAAGGGCGATGGTGGTTACAAACGGAATTGAACGTGCCATCCAGTATTATCATGCCATCCGGGATTACC
TGCTGGAGCTCAATAGCCCCTATAAGGCAATTGTAGCTTTTTCCGGAGAGCATGAGTACGGTGGAGTAAAAGTTACAGAA
GCCACTCTAAACGGTTTTCCATCAAGCCAGATTGAAGACAAAATAGAGGAAGAGCCTTACCGCTTCCTGATCTGTGCCGA
CAAGTTCCAGACCGGCTATGACGAGCCGCTCCTGCACACAATGTATGTTGACAAAGTCCTTTCAGGGATTAAAGCCGTGC
AGACGCTCTCCCGGCTCAACAGGGCTCACCCGAAGAAGCACGATGTTTTTGTGCTTGACTTCATGAACGATACTGACACA
ATCCAGGATGCTTTCTCGGATTACTACCGTACCACGGTCCTTAGTGATGAGACCGATCCCAACAAGCTTCACGACCTTAA
ATCCGATCTTGATAGTTATCAGGCCTATTCCCCGGAGCAGATAGAGCAGTTCGTTGAACTTTACCTGGGAGGAGCTGATA
GGGATAAACTTGATCCGATCCTCGATGTCTGCGTTGCCACTTATAAAGACCATCTTGACGAAGACGAACAGGTTGACTTC
AAAAGCAAAGCAAAAGCTTTCTCCCGTACCTACGGCTTCCTCGCTTCAATCTTGCCATACACAAATGCCGATTGGGAAAA
GCTCTCAATCTTCCTCAATTTCTTGATACCAAAATTGCCTGCTCCAAGGGAGGAAGACCTTTCAAAAGGTATCCTCGAAG
CAATTGACATGGACAGTTACCGGGTAGAAAAACAGGCTGTTGTGAATATCCAGCTTCCTGATTCGGATTCCGAAATAGAG
CCGGTACCTACAGAAGCCGGTGGGTTCAAGCCAGAACCTGAGCTTGATCGGCTCAGCAATATCCTCAAAACTTTCAACGA
TCAATTTGGCAATATCCGCTGGACTGATAGCGATAGGGTACACAGGCTGATTACCGAGGAAATCCCTGCAAGGGTAGCTG
CAGATGTTGCTTATCAGAACGCGAAGAAAAACTCGGACAAGCAGAACGCCAAGATAGAGCATGACAAAGCCCTTGCTCGT
GTAATGATTGCCCTGATGAAAGACGACACCCAGCTTTTCAAATTGTTCAGCGACAACGAATCTTTCCGCAGAACGCTAAC
AGACGCAATTTTCGAGCGGACTTACTCACAATAA

Protein sequence :
MTTDTTEKGLETLIVEAMTGTKPDPAQTDMGREPSALYGVTGWILGRWQDYDREYAVDLVQLTEFLKSTQPEVAESLDLE
NASPTRQKFLARLQGEVAKRGIIEVLRNGLKHGKYDIDLFYGTPTPGNTKAEERYALNRFSVTRQLRYSRGETQLALDLC
LFINGLPVATFELKNSLTKQTVEDAVEQYKRDRDSRELLFQFGRCMVHFAVDDHEVKFCTQLNGKNSWFLPFNQGYNDGT
GNPPNPAGIKTDYLWKKILTPQGLTDILENYAQVVEEKDEKTGKKKKVQIFPRYHQLDVVRKLLAHAEWHGAGMRYLVQH
SAGSGKSNSIAWLAHQLISLKKDDKEIFDSIIVITDRRVLDKQIRDTIKQFAQVGSTVGHAERSGDLRKFIESGKKIIIS
TVQKFPFILDEIGNEHRGRKFAIIIDEAHSSQGGRTAAAMSEALSDSKDQKDPEDTINDALQKRMEARKMLPNASYFAFT
ATPKNKTLELFGEPYKDGDKIKHRPFHNYTMKQAIQEGFILDVLRYYTPVNSYYKLIKTVESDPEFDTKKAKKKLRKYVE
SHDYAIRLKAEIIVDHFQEQVIALNKIGGQARAMVVTNGIERAIQYYHAIRDYLLELNSPYKAIVAFSGEHEYGGVKVTE
ATLNGFPSSQIEDKIEEEPYRFLICADKFQTGYDEPLLHTMYVDKVLSGIKAVQTLSRLNRAHPKKHDVFVLDFMNDTDT
IQDAFSDYYRTTVLSDETDPNKLHDLKSDLDSYQAYSPEQIEQFVELYLGGADRDKLDPILDVCVATYKDHLDEDEQVDF
KSKAKAFSRTYGFLASILPYTNADWEKLSIFLNFLIPKLPAPREEDLSKGILEAIDMDSYRVEKQAVVNIQLPDSDSEIE
PVPTEAGGFKPEPELDRLSNILKTFNDQFGNIRWTDSDRVHRLITEEIPARVAADVAYQNAKKNSDKQNAKIEHDKALAR
VMIALMKDDTQLFKLFSDNESFRRTLTDAIFERTYSQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC1765 NP_231400.1 type I restriction enzyme HsdR Not tested VPI-2 Protein 1e-177 41
VC0395_A1363 YP_001217306.1 type I restriction enzyme HsdR Not tested VPI-2 Protein 1e-177 41
VPI2_0013c ACA01830.1 type I restriction enzyme HsdR Not tested VPI-2 Protein 3e-177 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
MM_2976 NP_635000.1 type I restriction-modification system restriction subunit VFG1098 Protein 5e-178 41