Gene Information

Name : 2SCK31.18; metB (SCO4958)
Accession : NP_629110.1
Strain : Streptomyces coelicolor A3(2)
Genome accession: NC_003888
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 5393841 - 5395001 bp
Length : 1161 bp
Strand : +
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
GTGCCCATGAGCGACAGGCACATCAGTCAGCACTTCGAGACGCTCGCGATCCACGCGGGCAACACCGCCGATCCCCTGAC
GGGCGCGGTCGTCCCGCCGATCTATCAGGTGTCGACCTACAAGCAGGACGGCGTCGGCGGATTGCGCGGCGGCTACGAGT
ACAGCCGCAGCGCCAACCCGACCCGTACCGCGCTGGAGGAGAACCTCGCCGCCCTGGAGGGCGGCCGCCGCGGCCTCGCG
TTCGCGTCCGGACTGGCGGCCGAGGACTGCCTGTTGCGTACGCTGCTGCGCCCCGGCGACCACGTGGTGATCCCGAACGA
CGCGTACGGCGGCACCTTCCGCCTCTTCGCCAAGGTCGCCACCCGGTGGGGTGTGGAGTGGTCCGTGGCCGACACGAGCG
ACGCCGCCGCCGTGCGGGCCGCCCTCACCCCGAAGACCAAGGCGGTGTGGGTGGAGACGCCCTCCAACCCGCTGCTCGGC
ATCACCGACATCGCGCAGGTCGCCCAGGTCGCCCGGGACGCCGGCGCCCGGCTCGTCGTCGACAACACCTTCGCCACCCC
GTACCTCCAGCAGCCGCTGGCCCTCGGCGCCGACGTCGTCGTGCACTCGCTGACCAAGTACATGGGCGGGCACTCGGACG
TCGTGGGCGGCGCGCTGATCGTGGGCGACCAGGAGCTGGGCGAGGAGCTGGCGTTCCACCAGAACGCGATGGGCGCGGTC
GCCGGACCCTTCGACTCCTGGCTGGTGCTGCGCGGCACCAAGACCCTCGCCGTGCGCATGGACCGGCACAGCGAGAACGC
GACCAAGGTCGCCGACATGCTCTCCCGGCACGCGCGCGTGACGAGCGTGCTGTACCCGGGGCTGCCCGAGCACCCGGGGC
ACGAGGTCGCCGCCAAGCAGATGAAGGCGTTCGGCGGCATGGTGTCGTTCCGCGTCGAGGGCGGCGAGCAGGCCGCCGTC
GAGGTGTGCAACCGCGCGAAGGTCTTCACGCTCGGCGAGTCCCTCGGCGGCGTCGAGTCGCTGATCGAGCACCCGGGCCG
GATGACGCACGCCTCCGCGGCGGGCTCGGCCCTGGAGGTGCCCGCCGACCTGGTGCGGCTGTCGGTCGGCATCGAGAACG
CCGACGACCTGCTGGCCGACCTCCAGCAGGCGCTGGGCTAG

Protein sequence :
MPMSDRHISQHFETLAIHAGNTADPLTGAVVPPIYQVSTYKQDGVGGLRGGYEYSRSANPTRTALEENLAALEGGRRGLA
FASGLAAEDCLLRTLLRPGDHVVIPNDAYGGTFRLFAKVATRWGVEWSVADTSDAAAVRAALTPKTKAVWVETPSNPLLG
ITDIAQVAQVARDAGARLVVDNTFATPYLQQPLALGADVVVHSLTKYMGGHSDVVGGALIVGDQELGEELAFHQNAMGAV
AGPFDSWLVLRGTKTLAVRMDRHSENATKVADMLSRHARVTSVLYPGLPEHPGHEVAAKQMKAFGGMVSFRVEGGEQAAV
EVCNRAKVFTLGESLGGVESLIEHPGRMTHASAAGSALEVPADLVRLSVGIENADDLLADLQQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-73 48
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-74 48
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 9e-56 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
2SCK31.18; metB NP_629110.1 cystathionine gamma-synthase BAC0207 Protein 3e-60 44