Gene Information

Name : SCD19.10 (SCO4355)
Accession : NP_628525.1
Strain : Streptomyces coelicolor A3(2)
Genome accession: NC_003888
Putative virulence/resistance : Resistance
Product : nucleotidyltransferase
Function : -
COG functional category : R : General function prediction only
COG ID : COG1708
EC number : -
Position : 4769704 - 4770477 bp
Length : 774 bp
Strand : +
Note : SCD19.10, probable nucleotidyltransferase, len: 257 aa; similar to SW:S3AD_STAAU (EMBL:X02588) Staphylococcus aureus streptomycin 3''-adenylyltransferase (EC 2.7.7.47) Spc, 260 aa; fasta scores: opt: 644 z-score: 760.8 E(): 0; 44.5% identity in 227 aa ove

DNA sequence :
ATGCCAGACCGGGACCGGGACCGCACCGATCACCTCGTCGCCCTCGTCCGGCGGCACCTCGACGAGGACGGCGACGTGCT
CGGCGTCTACGCGCACGGCTCGGCCACCCTCGGCGGACTGCGCCCGTACAGCGACCTCGACCTCCTCGTCGTCCTGGGAC
GTCCGACCACGTACGGGCAACGCGAGCGGCTCACCGGGGAGTTGCTCGGCGTGTCCGGCGGTGAGGGGCGCCCCGTCGAG
CTGATCGCCGTCGTGCGGGACGAGGTCCGGCCCTGGCGGTATCCGCCCCGCCGGGAGTACCTGTACGGCGAGTGGCTGCG
CGACGCCTACGAGTGCGGGGCCGTCCCGGAGCCGGAGGACGACCCCGACCTGGCCCCGCTCCTGACCATGGTGCTGCGCG
CCGACGCCCCGCTGTACGGCCCGCCGCCCGCGACCCTGCTCGACCCCGTGCCCCACGGCGACCTGCGGCGGGCGATCACC
GCCGGGGTGCCGGAGCTGCTGGCCGGGCTGGAGCCGGACACGCGCAACGTGCTGCTCACCCTCGCCCGCGTCTGGAGCAC
GCTCGTCACCGGTGACATCCGGTCGAAGGACGCGGCGGCGGACTGGGCTCTGGGGCGGCTGCCCGCCTCGTACCGGCCGC
CGCTCGCCCACGCGCGCGCCGTCTACCTCGGGCAGGAGACGGAGGACTGGAGCGGCCTGGCGGTGCGGGCGTGCGCCGAC
CGGCTGGTCCGGGAGATCCGGGCGGCCTACGGGGACGGGGGGCCGGGGGAGTAG

Protein sequence :
MPDRDRDRTDHLVALVRRHLDEDGDVLGVYAHGSATLGGLRPYSDLDLLVVLGRPTTYGQRERLTGELLGVSGGEGRPVE
LIAVVRDEVRPWRYPPRREYLYGEWLRDAYECGAVPEPEDDPDLAPLLTMVLRADAPLYGPPPATLLDPVPHGDLRRAIT
AGVPELLAGLEPDTRNVLLTLARVWSTLVTGDIRSKDAAADWALGRLPASYRPPLAHARAVYLGQETEDWSGLAVRACAD
RLVREIRAAYGDGGPGE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
spc1 YP_039523.1 streptomycin 3''-adenylyltransferase 1 Not tested Type-II SCCmec Protein 1e-38 46
ant(9) NP_370577.1 O-nucleotidylltransferase Not tested Type-II SCCmec Protein 1e-38 46
ant(9) NP_373289.1 O-nucleotidylltransferase(9) Not tested Type-II SCCmec Protein 1e-38 46
ant(9) BAC57473.1 O-nucleotidyltransferase(9) Not tested Type-IIIinv SCCmec Protein 8e-39 46
spC YP_190051.1 streptomycin 3''-adenylyltransferase Not tested Type-II SCCmec Protein 1e-38 46
spc BAA82204.1 O-nucleotydiltransferase(9) Not tested Type-II SCCmec Protein 8e-39 46
aadA1 CAD92142.1 aminoglycoside adenyltransferase Not tested Not named Protein 9e-31 42
aadA1 YP_005797149.1 aminoglycoside 3'-adenyltransferase Not tested AbaR4e Protein 6e-31 42
aadA1 YP_006098376.1 aminoglycoside adenylyltransferase Not tested Tn2411 Protein 6e-31 42
aadDA1 CAJ77087.1 Aminoglycoside 3-adenylyltransferase Not tested AbaR1 Protein 5e-31 42
aadA1 ACN81025.1 AadA1 aminoglycoside (3')(9) adenylyltransferase Not tested AbaR5 Protein 6e-31 42
aadA1 ACV89835.1 AadA1 aminoglycoside (3')(9) adenylyltransferase Not tested AbaR7 Protein 5e-31 42
unnamed AFV53113.1 AadA1 aminoglycoside (3') adenyltransferase Not tested AbGRI2-1 Protein 5e-31 42
aadA1 AGK36646.1 AadA1 aminoglycoside (3')(9) adenylyltransferase Not tested AbaR26 Protein 5e-31 42
aadA1 ACY75515.1 aminoglycoside adenyltransferase Not tested Tn6060 Protein 9e-31 42
aadA1 YP_005797133.1 aminoglycoside 3'-adenyltransferase Not tested AbaR4e Protein 6e-31 42
aadA1 CAJ77048.1 Aminoglycoside adenylyltransferase Not tested AbaR1 Protein 5e-31 42
aadA25 YP_005176241.1 aminoglycoside 3''-O-adenyltransferase protein Not tested ICEPmu1 Protein 1e-30 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002745.1124853.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_009782.5559472.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002758.1120013.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002952.2859153.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002745.1122823.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002745.1124325.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002745.1125314.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase GU235985.1.orf1.gene Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_009782.5559439.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002758.1121631.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002952.2859154.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase NC_002745.1123578.p0 Protein 5e-39 46
SCD19.10 NP_628525.1 nucleotidyltransferase AJ704863.gene12.p01 Protein 2e-29 43
SCD19.10 NP_628525.1 nucleotidyltransferase NC_010558.1.6275994. Protein 8e-30 43
SCD19.10 NP_628525.1 nucleotidyltransferase DQ865198.gene.p01 Protein 8e-30 43
SCD19.10 NP_628525.1 nucleotidyltransferase AJ584652.2.gene7.p01 Protein 5e-31 43
SCD19.10 NP_628525.1 nucleotidyltransferase AY139598.1.gene2.p01 Protein 1e-29 42
SCD19.10 NP_628525.1 nucleotidyltransferase AM932669.1.gene3.p01 Protein 3e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase AY339625.2.gene17.p0 Protein 3e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase JN596991.2.gene3.p01 Protein 6e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase FR748153.1.gene5.p01 Protein 6e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase AY123251.gene3.p01 Protein 3e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase NC_010410.6003168.p0 Protein 3e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase Y18050.2.gene6.p01 Protein 6e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase AF313471.1.gene3.p01 Protein 3e-31 42
SCD19.10 NP_628525.1 nucleotidyltransferase NC_010410.6003170.p0 Protein 3e-31 42