Gene Information

Name : SCQ11.11; thiC (SCO3928)
Accession : NP_628113.1
Strain : Streptomyces coelicolor A3(2)
Genome accession: NC_003888
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 4321756 - 4323594 bp
Length : 1839 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGACCATCAAGGACGCACGCACGCCTGCCTCCACGCAGAACACCGCCCAGGCGGACACCGCGGAGAACACGGACACCGC
GGAGGACACCGAGGCCGGGAAGTCCATCGGCTGGCACAAGGCGTACGTCGAGGGCTCGCGCCCCGATCTGCGGGTGCCGG
TCCGTCAGGTGCACCTCACCAACGGGCAGTCGGTCACGCTCTACGACACCTCGGGCCCGTACACCGATCCGCTCGTCGAC
ACCGATGTCCGCAGGGGCCTCGCACCGCTGCGGGAGAACTGGATCATCGCCCGCGGAGACACCGAGGAGTACGCGGGCCG
CCCCGTCCGGCCCGAGGACGACGGAATCAAGCACACCTCGCCGCGCGGCGGCCTGCGCAACCTCGACGCCGTCTTCCCCG
GCCGCCCGCGCCAGCCTCGCCGGGGCCGGGACGGCAACGCGGTCACGCAGCTCGCCTACGCGCGACGGGGCGAGATCACC
CCGGAGATGGAGTACGTGGCCGTCCGGGAGAACGTCTCCCCGGAGGTGGTCCGCGAGGAGATCGCCGCGGGACGTGCCGT
GCTGCCCGCCAACATCAACCACCCCGAGATCGAGCCGATGATCATCGGCAAGCGGTTCCTGGTGAAGGTCAACGCCAACA
TCGGCAACTCGGCGGTGACGTCCTCCATCGAGGAGGAGGTGGACAAGATGACCTGGGCGACCCGGTGGGGTGCCGACACG
GTCATGGACCTCTCCACCGGCCGCAACATCCACACCACCCGCGAGTGGGTCCTGCGCAACTCCCCCGTTCCCATCGGAAC
CGTGCCGCTCTACCAGGCCCTGGAGAAGGTCGACGGCCGCGCCGAGGAGCTGACCTGGGAGATCTACAAGGACACCGTCA
TCGAGCAGGCGGAGCAGGGCGTGGACTACATGACGGTCCACGCGGGCGTGCGCCTGCCGTACGTGCCCCTCACCGCGAAC
CGCAAGACGGGCATCGTCTCGCGCGGCGGCTCGATCATGGCGGCGTGGTGCCTGGCGCACCACAAGGAGTCGTTCCTCTA
CGAGAACTTCGAGGAACTCTGCGAGATCCTCGCCGCCTACGACGTCACCTACTCCCTCGGCGACGGCCTGCGTCCGGGGT
CGATCGCGGACGCCAACGACGAGGCGCAGTTCGCCGAGTTGCGCACGCTCGGGGAACTCAACCGGATCGCCAAGCGTTGC
AGCGTACAGACCATGATCGAGGGCCCGGGACATGTCCCGATGCACAAGATCAAGGAGAACATCGACCTTCAGCAGGAGAT
CTGCGATGAAGCTCCGTTCTATACGCTCGGCCCGCTGACGACGGACGTCGCGCCGGCGTACGACCACATCACCTCCGGCA
TCGGTGCCGCGATGATCGCCTGGTGGGGCACGGCCATGCTCTGCTACGTCACGCCCAAGGAACACCTGGGCCTGCCCAAC
CGTGACGACGTCAAGACCGGCGTCATCACCTACAAGATCGCCGCCCATGCCGCCGACCTCGCCAAGGGTCACCCAGGTGC
ACAGGAGTGGGACGACGCGCTGTCGGACGCCCGGTTCGAGTTCCGGTGGGAGGACCAGTTCAACCTGGCCCTCGACCCCG
ACACGGCACGGGAGTTCCACGACGAGACACTGCCGGCCGAGCCCGCCAAGACGGCCCACTTCTGCTCGATGTGCGGGCCC
AAGTTCTGCTCGATGAAGATTAGTCAAAGCATCACAGAGCAGTTCGGTGGTACGGCGGCTGCGGGGGCGACGGCTGAGGA
GGTCGCTGCGGGGATGCTCCAGAAGTCGAAGGAGTTCGCCGAGAGCGGGAACCGGGTGTACTTGCCGCTCGCCGACTGA

Protein sequence :
MTIKDARTPASTQNTAQADTAENTDTAEDTEAGKSIGWHKAYVEGSRPDLRVPVRQVHLTNGQSVTLYDTSGPYTDPLVD
TDVRRGLAPLRENWIIARGDTEEYAGRPVRPEDDGIKHTSPRGGLRNLDAVFPGRPRQPRRGRDGNAVTQLAYARRGEIT
PEMEYVAVRENVSPEVVREEIAAGRAVLPANINHPEIEPMIIGKRFLVKVNANIGNSAVTSSIEEEVDKMTWATRWGADT
VMDLSTGRNIHTTREWVLRNSPVPIGTVPLYQALEKVDGRAEELTWEIYKDTVIEQAEQGVDYMTVHAGVRLPYVPLTAN
RKTGIVSRGGSIMAAWCLAHHKESFLYENFEELCEILAAYDVTYSLGDGLRPGSIADANDEAQFAELRTLGELNRIAKRC
SVQTMIEGPGHVPMHKIKENIDLQQEICDEAPFYTLGPLTTDVAPAYDHITSGIGAAMIAWWGTAMLCYVTPKEHLGLPN
RDDVKTGVITYKIAAHAADLAKGHPGAQEWDDALSDARFEFRWEDQFNLALDPDTAREFHDETLPAEPAKTAHFCSMCGP
KFCSMKISQSITEQFGGTAAAGATAEEVAAGMLQKSKEFAESGNRVYLPLAD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 66
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 66
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 5e-165 58