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Name : vanB (SCO3595) Accession : NP_627790.1 Strain : Streptomyces coelicolor A3(2) Genome accession: NC_003888 Putative virulence/resistance : Resistance Product : D-alanine--D-lactate ligase Function : - COG functional category : M : Cell wall/membrane/envelope biogenesis COG ID : COG1181 EC number : - Position : 3972317 - 3973357 bp Length : 1041 bp Strand : + Note : vancomycin B-type resistance protein; catalyzes the formation of D-alanyl-D-lactate in peptidoglycan synthesis DNA sequence : TTGGCCAGGTTGAAGGTCGGCATCGTATTCGGGGGCTCTTCCGAAGAACACGCCGTTTCCGTCAAGTCCGCCCAGGAGGT CGCACGCAACCTCGACACCGAGAAGTACCAGCCGTTCTTCGTGGGGATCACGAAGGACGGCGCCTGGAGACTCTGCGACG GGCCAGGCCAGGACTGGGAGAACGGCGACTGCCGTCCGGTCGTGCTGTCACCGGACCGGAGCGTGCACGGGCTGCTCGTC CTGGAGCAGGGGCAGTACCGGTCGGTCCGCCTGGACGTCGTCCTTCCCGTCCTGCACGGCACCCTCGGTGAGGACGGTGC GACGCAGGGGCTGCTGGAGCTCTCCGGCATTCCGTACGTGGGCTGCGACGTCCAGAGCTCCGCCCTGTGCATGGACAAAT CCCTTGCGTACGTCGTCGCCAGGAGCGCGGGGATCGCCACGCCGGATTTCTGGACCGTGACAGGAGACGAGACCATCGAT CCCGGCCGGCTCACGTATCCCGTCTTCGTGAAGCCGGCCCGTTCGGGGTCGTCCTTCGGCGTCAGCAAGGTGTGCCGCCC GGAAGACCTGGCGACCGCGGTGGAGTCCGCCCGGCGGTACGACACGAAGGTGCTGATCGAAGCGGCCGTCGTCGGCAGCG AGGTCGGCTGCGCCATCCTGGGGAACGACCCCGACCTGATCGTGGGCGAGGTGGACCGCATCGCGCTCTCCCACGGATTC TTCCGGATCCACCAGGAGGAGCAGCCCGAGAACGGCTCGGAGAACTCGACGCCGGTCGTTCCCGCCGACATCCCGACGGA GAAGCGGTCGCTCGTCCAGGAGACCGCGAAGGCCGTGTACCGAGCCCTGGGATGCCGGGGGCTGTCCCGCGTGGACATGT TCCTCAAGGAGGACGGGGAAGTCGTCCTCAACGAGGTCAACACCCTGCCCGGCATGACCTCGTACAGCCGTTATCCGAGG ATGATGGCGGCCGCGGGGCTGCCACTGTCCGAGGTGATCGACCGGACGCTGTCCCTGGCGTTGACGGGGAAGCTCCGATG A Protein sequence : MARLKVGIVFGGSSEEHAVSVKSAQEVARNLDTEKYQPFFVGITKDGAWRLCDGPGQDWENGDCRPVVLSPDRSVHGLLV LEQGQYRSVRLDVVLPVLHGTLGEDGATQGLLELSGIPYVGCDVQSSALCMDKSLAYVVARSAGIATPDFWTVTGDETID PGRLTYPVFVKPARSGSSFGVSKVCRPEDLATAVESARRYDTKVLIEAAVVGSEVGCAILGNDPDLIVGEVDRIALSHGF FRIHQEEQPENGSENSTPVVPADIPTEKRSLVQETAKAVYRALGCRGLSRVDMFLKEDGEVVLNEVNTLPGMTSYSRYPR MMAAAGLPLSEVIDRTLSLALTGKLR |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| vanB | YP_008394259.1 | Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase | Not tested | Not named | Protein | 1e-110 | 65 |
| vanB | NP_815951.1 | D-alanine--D-lactate ligase | Not tested | Not named | Protein | 2e-108 | 64 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | AY145441.gene.p01 | Protein | 2e-110 | 65 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | AF310956.2.orf5.gene | Protein | 2e-110 | 65 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | AF277571.gene.p01 | Protein | 6e-115 | 65 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | U35369.1.gene6.p01 | Protein | 1e-108 | 64 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | AE016830.1.gene2250. | Protein | 1e-108 | 64 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | U00456.gene.p01 | Protein | 1e-108 | 64 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | AY489045.gene.p01 | Protein | 1e-110 | 64 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | NC_005054.2598280.p0 | Protein | 8e-112 | 63 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | NC_014475.1.orf3.gen | Protein | 8e-112 | 63 |
| vanB | NP_627790.1 | D-alanine--D-lactate ligase | AF130997.1.orf4.gene | Protein | 2e-111 | 62 |
