Gene Information

Name : SCE33.15c (SCO3013)
Accession : NP_627235.1
Strain : Streptomyces coelicolor A3(2)
Genome accession: NC_003888
Putative virulence/resistance : Virulence
Product : two-component system response regulator
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 3288890 - 3289579 bp
Length : 690 bp
Strand : -
Note : SCE33.15c, probable two-component system response regulator, len: 229 aa; similar to TR:Q50447 (EMBL:Z95121) Mycobacterium tuberculosis MtrA, 228 aa; fasta scores: opt: 1141 z-score: 1397.7 E(): 0; 74.9% identity in 227 aa overlap, to SW:AFQ1_STRCO (EMBL:

DNA sequence :
ATGATGTCGTTTATGAAGGGACGAGTCCTTGTCGTCGACGACGACACCGCACTGGCCGAGATGCTCGGCATTGTGCTGCG
TGGTGAGGGTTTTGAGCCGTCTTTCGTAGCCGACGGCGACAAGGCGCTGGCCGCCTTCCGGGAGACCAAGCCGGACCTGG
TGCTGCTCGACCTGATGCTGCCCGGACGGGACGGCATCGAGGTGTGCCGCCTGATCAGGGCGGAGTCGGGTGTGCCGATC
GTGATGCTGACGGCGAAGAGCGACACCGTCGACGTCGTGGTGGGTCTGGAGTCGGGCGCCGACGACTACATCGTGAAGCC
GTTCAAGCCGAAGGAGCTGGTGGCCCGGATCCGGGCGCGGCTGCGCAGGTCGGAGGAACCGGCGCCGGAGCAGCTCGCCA
TAGGCGACCTGGTCATCGACGTGGCCGGTCACTCCGTGAAGCGGGACGGGCAGTCGATCGCGCTGACGCCGCTGGAGTTC
GACCTGCTGGTGGCGCTGGCCCGCAAGCCGTGGCAGGTGTTCACGCGCGAGGTGCTCCTCGAGCAGGTCTGGGGCTACCG
GCACGCCGCCGACACCCGCCTGGTCAACGTGCACGTCCAGCGGCTGCGCTCCAAGGTCGAGAAGGACCCGGAGAAGCCGG
AGATCGTGGTGACCGTCCGCGGCGTCGGCTACAAGGCCGGACCGAGCTGA

Protein sequence :
MMSFMKGRVLVVDDDTALAEMLGIVLRGEGFEPSFVADGDKALAAFRETKPDLVLLDLMLPGRDGIEVCRLIRAESGVPI
VMLTAKSDTVDVVVGLESGADDYIVKPFKPKELVARIRARLRRSEEPAPEQLAIGDLVIDVAGHSVKRDGQSIALTPLEF
DLLVALARKPWQVFTREVLLEQVWGYRHAADTRLVNVHVQRLRSKVEKDPEKPEIVVTVRGVGYKAGPS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
c3565 NP_755440.1 response regulator Not tested PAI I CFT073 Protein 1e-37 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SCE33.15c NP_627235.1 two-component system response regulator AE000516.2.gene3505. Protein 2e-80 75
SCE33.15c NP_627235.1 two-component system response regulator BAC0125 Protein 3e-34 46
SCE33.15c NP_627235.1 two-component system response regulator NC_002952.2859905.p0 Protein 5e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_007622.3794472.p0 Protein 5e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_009641.5332272.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_013450.8614421.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_007793.3914279.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_002745.1124361.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_009782.5559369.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_002951.3237708.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_003923.1003749.p0 Protein 7e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_002758.1121668.p0 Protein 8e-46 46
SCE33.15c NP_627235.1 two-component system response regulator NC_012469.1.7685629. Protein 9e-45 46
SCE33.15c NP_627235.1 two-component system response regulator NC_012469.1.7686381. Protein 4e-42 45
SCE33.15c NP_627235.1 two-component system response regulator HE999704.1.gene2815. Protein 8e-42 45
SCE33.15c NP_627235.1 two-component system response regulator NC_002952.2859858.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_007622.3794948.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_003923.1003417.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_013450.8614146.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_002951.3238224.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_007793.3914065.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_002758.1121390.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator NC_010079.5776364.p0 Protein 8e-40 43
SCE33.15c NP_627235.1 two-component system response regulator AE015929.1.gene1106. Protein 4e-36 43
SCE33.15c NP_627235.1 two-component system response regulator BAC0039 Protein 7e-41 43
SCE33.15c NP_627235.1 two-component system response regulator CP001918.1.gene3444. Protein 7e-40 43
SCE33.15c NP_627235.1 two-component system response regulator BAC0596 Protein 1e-40 43
SCE33.15c NP_627235.1 two-component system response regulator CP000034.1.gene2186. Protein 7e-41 43
SCE33.15c NP_627235.1 two-component system response regulator NC_002695.1.916589.p Protein 7e-41 43
SCE33.15c NP_627235.1 two-component system response regulator CP001138.1.gene2239. Protein 1e-40 43
SCE33.15c NP_627235.1 two-component system response regulator HE999704.1.gene1528. Protein 1e-34 42
SCE33.15c NP_627235.1 two-component system response regulator AF155139.2.orf0.gene Protein 2e-35 42
SCE33.15c NP_627235.1 two-component system response regulator CP000647.1.gene2531. Protein 3e-39 42
SCE33.15c NP_627235.1 two-component system response regulator AE016830.1.gene1681. Protein 1e-40 41
SCE33.15c NP_627235.1 two-component system response regulator FJ349556.1.orf0.gene Protein 1e-36 41
SCE33.15c NP_627235.1 two-component system response regulator BAC0197 Protein 5e-32 41
SCE33.15c NP_627235.1 two-component system response regulator CP000034.1.gene3671. Protein 7e-37 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
SCE33.15c NP_627235.1 two-component system response regulator VFG1390 Protein 2e-35 44
SCE33.15c NP_627235.1 two-component system response regulator VFG1389 Protein 6e-32 44
SCE33.15c NP_627235.1 two-component system response regulator VFG1702 Protein 5e-38 41