Gene Information

Name : smpB (SCO2966)
Accession : NP_627190.1
Strain : Streptomyces coelicolor A3(2)
Genome accession: NC_003888
Putative virulence/resistance : Unknown
Product : SsrA-binding protein
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0691
EC number : -
Position : 3227050 - 3227529 bp
Length : 480 bp
Strand : -
Note : binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Ca

DNA sequence :
ATGGCTAAGGAAAAAGGGCGCAAGCTGATCGCGCAGAACAAGAAGGCGCGGCACGACTACCAGATCCTCGACACCTACGA
GGCCGGCCTCGTGCTGTCCGGTACCGAGGTGAAGTCGCTGCGCCAGGGGCGGGCCTCGCTGGCCGACGGGTTCGTGCAGC
TGGACGGCCACGAGGCGTGGCTGCACAACGTGCACGTGCCGGAGTACAGCCAGGGCACCTGGACCAACCACAGCGCGCGG
CGCAAGCGGAAGCTGCTGCTGCACCGGGTGGAGATCGACAAGCTGGAGTCGAAGTCCCAGGAGACCGGTCACACGATCGT
GCCCCTGGCGCTCTACTTCAAGGACGGGCGGGCCAAGGTCGAGATCGCGCTGGCGCGCGGCAAGAAGGAGTACGACAAGC
GGCAGACCCTCCGGGAGAAGCAGGACCGGCGCGAGGCGGAGCGGACGATCTCCGCGATCAAGCGCAAGCAGCGGGCCTGA

Protein sequence :
MAKEKGRKLIAQNKKARHDYQILDTYEAGLVLSGTEVKSLRQGRASLADGFVQLDGHEAWLHNVHVPEYSQGTWTNHSAR
RKRKLLLHRVEIDKLESKSQETGHTIVPLALYFKDGRAKVEIALARGKKEYDKRQTLREKQDRREAERTISAIKRKQRA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
smpB YP_001800894.1 SsrA-binding protein Not tested Not named Protein 4e-40 56
unnamed AET14351.1 SsrA-binding protein Not tested SaPI68111 Protein 1e-33 52
smpB NP_230495.1 SsrA-binding protein Not tested VPI-1 Protein 6e-20 41