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Name : leuS (SCO2571) Accession : NP_626809.1 Strain : Streptomyces coelicolor A3(2) Genome accession: NC_003888 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 2775536 - 2778436 bp Length : 2901 bp Strand : - Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGAGCGAGACGAACCCCGCGGCGACCGCCCCTGTGTCGGCGGATGCCGCGCCGCACCGCTACACGGCTGCCATGGCCGC CGAGATCGAGGCACGCTGGCAGGACTTCTGGGACGCCGAGGGGACGTACGCCGCGCCGAACCCCAAGGGTGACCTGGCGG GCGACCCGGAGCTGGTCGCCAAGCCCAAGAAGTTCATCATGGACATGTTCCCGTACCCCTCGGGTGCGGGCCTGCACGTC GGCCACCCCCTGGGGTACATCGCCACCGACGTCTTCGCCCGCTTCCAGCGGATGACCGGCCACAACGTCCTGCACACCCT GGGCTTCGACGCCTTCGGCCTGCCCGCCGAGCAGTACGCCGTGCAGACCGGCACGCACCCGCGCGTGTCCACCGAAGCCA ACATGAAGAACATGCAGAGCCAGCTGCGCCGGCTGGGTCTGGGCCACGACAGGCGCAGGTCGTTCGCCACGATCGACCCC GAGTACTACAAGTGGACCCAGTGGATCTTCCTGCAGATCTTCAACTCCTGGTACGACGACGAGGCGAAGAAGGCCCGTCC GATCGCCGAGCTGGTCGCGCAGTTCGCCTCCGGTGAGCGGGAGGTCCCGGGCCACGCGGGCCGGGCGTGGAGCAGCCTGA GCGAGGCCGAGCGCGCCGACGTGCTGGGCGAGTACCGCCTGGCCTACGCCTCCGACGCGCCGGTCAACTGGTGCCCCGGA CTGGGCACCGTGCTGGCCAACGAGGAGGTCACCGCCGACGGCCGTTCCGAGCGCGGCAACTTCCCCGTCTTCAAGTCCAA GCTGCGCCAGTGGAACATGCGCATCACCGCCTACGCGGACCGGCTGCTGGACGACCTGGACCAGCTGGACTGGCCCGAGG CGATCAAGCTGCAGCAGCGCAACTGGATCGGCCGCTCCGAGGGCGCCCGCGTCGACTTCCCCGTGGACGGCGAGCGCATC ACCGTCTTCACCACCCGCCCCGACACCCTGTTCGGCGCGACCTACATGGTGCTGGCGCCCGAGCACCCGCTGGTCGAGAA GTTCACCCCGGCCGTCTGGCCCGAGGGCACCCGCGACGCGTGGACCGGCGGCCACGCCACCCCGACCGAGGCCGTCGCCG CGTACCGCGCGCAGGCCGCCTCCAAGTCCGACGTCGAGCGGCAGGCCGAGGCCAAGGACAAGACCGGCGTCTTCATCGGC GCGTACGCCACCAACCCGGTCAACGGCGAGCAGGTCCCGGTCTTCGTCGCCGACTACGTGCTGATGGGCTACGGCACCGG CGCCATCATGGCCGTCCCGGCGCACGACTCCCGCGACTTCGAGTTCGCGCGCGCCTTCGAGCTGCCCGTCAGGTGCGTCG TCGAGCCGACGGACGGCCGCGGCACCGACACGTCGACGTGGGACGAGGCCTTCGCCTCCTACGACGCGAAGATCGTGAAC TCCTCCGGTACGGACGTCTCCCTGGACGGTCTGGGCGTCGTCGAGGCCAAGGAGCGCGTCACCGAGTGGCTGGAGCGCGC CGGAGCCGGTGCGGGCACCGTCAACTTCCGCCTGCGCGACTGGCTGTTCAGCCGCCAGCGCTACTGGGGCGAGCCCTTCC CGATCGTCTACGACGAGGACGGCATCGCCCACCCCCTGCCCGACTCGATGCTGCCGCTGGAGCTGCCGGAGGTCGAGGAC TACTCCCCGCGCACCTTCGACCCGGACGACGCCGACACCAAGCCCGAGACCCCGCTGTCCCGCAACGAGGACTGGGTCCA CGTCACCCTGGACCTGGGCGACGGCCGCGGCCCGCGCAAGTACCGCCGCGAGACCAACACCATGCCCAACTGGGCCGGCT CCTGCTGGTACGAGCTGCGCTACCTGGACCCGCACAACGGCGAGCGGCTGGTCGACCCCGAGATCGAGCAGTACTGGATG GGCCCGCGCGAGGGCCTGCCGCACGGCGGCGTCGACCTGTACGTCGGCGGCGCCGAGCACGCCGTGCTGCACCTGCTGTA CGCGCGCTTCTGGTCCAAGGTGCTGTTCGACCTGGGGCACGTCTCCTCGGCCGAGCCGTTCCACAAGCTGTTCAACCAGG GCATGATCCAGGCCTACGTCTACCGGGACAGCCGCGGCATCGCCGTACCGGCCGCCGAGGTGGAGGAGCGCGACGGCGCC TACTACTACCAGGGCGAGAAGGTCTCCCGGCTGCTGGGCAAGATGGGCAAGTCCCTGAAGAACGCGGTCACCCCCGACGA GATCTGCGCCGAGTACGGCGCCGACACGCTGCGCCTGTACGAGATGGCGATGGGCCCGCTGGACGTGTCGCGGCCGTGGG ACACGCGCGCGGTGGTCGGCCAGTTCCGGCTGCTGCAGCGGCTGTGGCGCAACGTCGTCGACGAGGACACCGGCGAGCTG TCCGTGGCGGACGTCGCGGAGAGCGACATCGACGCCGGCACCCTGCGTGCCCTGCACAAGGCCGTCGACGGCGTGCGGCA GGACCTGGAGGGCATGCGGTTCAACACCGCCATCGCCAAGGTCACCGAGCTGAACAACCACCTGACCAAGGCCGGGGGCC CGGTCCCGCGGTCGGTCGCCGAGCGCCTGGTGCTGCTGGTCGCGCCGCTGGCCCCGCACGTCGCCGAGGAGCTGTGGCGC AAGCTGGGGCACGAGTCCTCCGTCGTCCACGAGGACTTCCCGGTCGCCGACCCGGCCTACGTCGTCGACGAGACCGTGAC CTGCGTCGTCCAGATCAAGGGCAAGGTCAAGGCACGGCTGGAGGTCGCCCCCTCCATCTCCGAGGACGACCTGGAGAAGG CCGCGCTGGCCGACGAGAAGGTCGTGGCCGCGCTGGGCGGGGCCGGGATCCGCAAGGTGATCGTGCGGGCGCCGAAGCTG GTGAACATCGTCCCCGCCTAG Protein sequence : MSETNPAATAPVSADAAPHRYTAAMAAEIEARWQDFWDAEGTYAAPNPKGDLAGDPELVAKPKKFIMDMFPYPSGAGLHV GHPLGYIATDVFARFQRMTGHNVLHTLGFDAFGLPAEQYAVQTGTHPRVSTEANMKNMQSQLRRLGLGHDRRRSFATIDP EYYKWTQWIFLQIFNSWYDDEAKKARPIAELVAQFASGEREVPGHAGRAWSSLSEAERADVLGEYRLAYASDAPVNWCPG LGTVLANEEVTADGRSERGNFPVFKSKLRQWNMRITAYADRLLDDLDQLDWPEAIKLQQRNWIGRSEGARVDFPVDGERI TVFTTRPDTLFGATYMVLAPEHPLVEKFTPAVWPEGTRDAWTGGHATPTEAVAAYRAQAASKSDVERQAEAKDKTGVFIG AYATNPVNGEQVPVFVADYVLMGYGTGAIMAVPAHDSRDFEFARAFELPVRCVVEPTDGRGTDTSTWDEAFASYDAKIVN SSGTDVSLDGLGVVEAKERVTEWLERAGAGAGTVNFRLRDWLFSRQRYWGEPFPIVYDEDGIAHPLPDSMLPLELPEVED YSPRTFDPDDADTKPETPLSRNEDWVHVTLDLGDGRGPRKYRRETNTMPNWAGSCWYELRYLDPHNGERLVDPEIEQYWM GPREGLPHGGVDLYVGGAEHAVLHLLYARFWSKVLFDLGHVSSAEPFHKLFNQGMIQAYVYRDSRGIAVPAAEVEERDGA YYYQGEKVSRLLGKMGKSLKNAVTPDEICAEYGADTLRLYEMAMGPLDVSRPWDTRAVVGQFRLLQRLWRNVVDEDTGEL SVADVAESDIDAGTLRALHKAVDGVRQDLEGMRFNTAIAKVTELNNHLTKAGGPVPRSVAERLVLLVAPLAPHVAEELWR KLGHESSVVHEDFPVADPAYVVDETVTCVVQIKGKVKARLEVAPSISEDDLEKAALADEKVVAALGGAGIRKVIVRAPKL VNIVPA |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 5e-140 | 49 |
