Gene Information

Name : PolA (TTE0874)
Accession : NP_622526.1
Strain : Thermoanaerobacter tengcongensis MB4
Genome accession: NC_003869
Putative virulence/resistance : Unknown
Product : DNA polymerase I
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0749
EC number : -
Position : 882689 - 885304 bp
Length : 2616 bp
Strand : +
Note : has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair

DNA sequence :
ATGGCAAAGTTTCTGTTAATTGATGGTAGCAGTCTGATGTACAGGGCTTATTATGCCTTACCGATGCTTACTACCAGTGA
GGGATTACATACAAATGCATTGTACGGCTTTACTATGATGTTAATAAAATTGCTGGAGGAAGAAAAACCTGACTATGTGG
CAATCGCTTTTGACAAAAAAGCTCCGACTTTCAGGCATAAAGAGTTTAAGGAGTACAAAGCCACCAGACAGGCTATGCCA
GAAGAACTTTCTGAACAGGTAGAGCTTTTAAAAGAAGTAATTGATGGCTTTAACATAAAGACTTTAGAATTGGAAGGATA
TGAAGCAGATGACATAATAGGAACAGTTTCAAAGATGGCAGAGGAAAAAGGGATGGAAGTGGTAATTGTCACGGGAGACA
GAGACGCTCTCCAACTTATTTCCCCCAGGGTAAAGGTGAAAATATCTAAAAAGGGCATAACGCAGATGGAAGAGTTTGAT
GAAAAAGCGGTATTAGAAAGGTATGAAATAACTCCGCAGCAGTTTGTGGATTTAAAGGGATTGATGGGGGACAAGTCGGA
CAATATTCCTGGAATACCTAATATAGGGGAAAAGACTGCTATCAAGCTTTTGAAGGAATTTGGCTCGGTGGAAAATCTTC
TTGAAAATATATCAAAATTGTCAGGAAAGATTAAAGAGACAATAGAAGCAAATAGAGAACTGGCTGTCATGAGCAAAAGA
TTAGCCACTATAAATAGGAATATTCCTCTTGAGATTGACTTTGAAGAGTATAGATTAAAAGAGTTTAATTACAAAAAATT
ATGGGACCTTTTTAACAAGCTTGAATTTTATAGCCTTCTAGACAGCATCAAAAAGGAAGGAGAAGAGGTCATTCCAACTG
TTTCAATAAGAAAGTGGAAAAAAGTTGACATTAGAGAAGTGCCAAGGCTTTTAGAAAGTGCAAAAAATGTTGCCTTTTAT
CCTTTGATCTATGAGGGGGATGTAAAAAAGATAGCATTTTCTTTTGATGGTACTACCCTTTATTCAGATGTTGAAAGGTT
AGAAGACTTAAGAAAAATATTTGAAAGAGAAGATGCTGAATTTGTTTCCCATGAGATAAAAGACTTCCTAGTGAAACTTT
CTTACAAAGGCATAGAATGTAAGAGTAAATATCTGGATACTGCTATAATGGCTTATCTTCTCAACCCTTCTGAGTCCAAT
TACGATTTGGAGAGGGTATTGAAAAGATACCTTAAAGTGGATATATTGTCCCATGAGGAAGTATTTGGGAAAGGAAAAGA
CAGGAGAAGGTATGAAGAAGTAAGCGAAGAAGTAATGGCAGAGTACATATGTGGAAGGTGCAGCCACTTATTTGAGTTAA
AAGATAAGCTTATGGCTTTTATTGAAGAGATGGACATGAAGAAGCTTTTGCTGGAAATAGAGATGCCTCTTGTGGAAGTT
TTAAAATCAATGGAAGTGGATGGATTTACACTGGACAGAAATGTTTTAAAGGAGCTTTCCGAAAAGATAGATGAGAGGAT
TTCTGAAATATTGGATAAAATTTACAAAGAAGCAGGATACCAGTTCAATGTAAATTCCCCAAAGCAGTTGGGAGAATTTC
TCTTTGAAAAGCTCAACCTACCCGTAATTAAAAAGACAAAGACAGGTTACTCGACTGATTCCGAAGTCTTAGAGCAGCTT
ACAGCTTATAATGACATTGTAAGTGAGATAATAGAGTACAGACAGCTTACCAAGCTCAAGTCTACTTACATAGAGGGTTT
TTTGCCCTTGATGGACGAAAATGACAGAGTGCATTCTAATTTCAAACAGATGGTGGCGGCGACTGGCAGGATAAGCAGCA
CAGAGCCTAATCTTCAGAATATACCTGTGAGGGAGGAGTTTGGAAGACAGATAAGGAGGGCTTTTATACCGAGGACAAAA
GACGGCTATATCGTCTCTGCAGACTATTCACAGATTGAATTGAGGGTTTTGGCACATCTTTCTGAAGATGAAAAGTTGAT
AGAAGCTTTTATGAACAATGAAGACATACACTTGAGGACGGCTTCCGAAGTCTTTAAAGTGCCTCCTCAAAATGTCACTC
CAGAGATGAGAAGAGCAGCTAAAGTAGTAAATTTTGGGATAATATATGGAATAAGCGATTATGGCTTGGCGAAAGACTTG
AAGATTTCGAGGAAAGAAGCTAAGGAATATATTGACAATTATTTTGAAAAGTATAAGGGAGTAAAAGAGTATATAGAAAA
GGTGATTCGATTTGCCAAGGAAAATGGATATGTGACTACTATAATGAACAGGAGGAGGTACATTCCTGAAATAAATTCGA
GGAATTTCACACAGCGCTCACAAGCGGAAAGGCTGGCTATGAATACGCCAATCCAAGGCAGTGCTGCCGACATAATAAAA
ATGGCTATGGTAAAAGTTTATCAAGAATTTAAGAGGTTGAATTTAAAGTCCAGGCTCATATTGCAGGTCCATGACGAGCT
TGTTGTTGATACTTATAAGGACGAGCTGGAGTTAGTGAAAGAAATACTCAAAGAAAACATGGAGAATGTGATAAAGCTGA
AAGTTCCGCTGGTTGTTGAAATTGGGGTGGGTCCTAACTGGTTTTTGGCTAAGTGA

Protein sequence :
MAKFLLIDGSSLMYRAYYALPMLTTSEGLHTNALYGFTMMLIKLLEEEKPDYVAIAFDKKAPTFRHKEFKEYKATRQAMP
EELSEQVELLKEVIDGFNIKTLELEGYEADDIIGTVSKMAEEKGMEVVIVTGDRDALQLISPRVKVKISKKGITQMEEFD
EKAVLERYEITPQQFVDLKGLMGDKSDNIPGIPNIGEKTAIKLLKEFGSVENLLENISKLSGKIKETIEANRELAVMSKR
LATINRNIPLEIDFEEYRLKEFNYKKLWDLFNKLEFYSLLDSIKKEGEEVIPTVSIRKWKKVDIREVPRLLESAKNVAFY
PLIYEGDVKKIAFSFDGTTLYSDVERLEDLRKIFEREDAEFVSHEIKDFLVKLSYKGIECKSKYLDTAIMAYLLNPSESN
YDLERVLKRYLKVDILSHEEVFGKGKDRRRYEEVSEEVMAEYICGRCSHLFELKDKLMAFIEEMDMKKLLLEIEMPLVEV
LKSMEVDGFTLDRNVLKELSEKIDERISEILDKIYKEAGYQFNVNSPKQLGEFLFEKLNLPVIKKTKTGYSTDSEVLEQL
TAYNDIVSEIIEYRQLTKLKSTYIEGFLPLMDENDRVHSNFKQMVAATGRISSTEPNLQNIPVREEFGRQIRRAFIPRTK
DGYIVSADYSQIELRVLAHLSEDEKLIEAFMNNEDIHLRTASEVFKVPPQNVTPEMRRAAKVVNFGIIYGISDYGLAKDL
KISRKEAKEYIDNYFEKYKGVKEYIEKVIRFAKENGYVTTIMNRRRYIPEINSRNFTQRSQAERLAMNTPIQGSAADIIK
MAMVKVYQEFKRLNLKSRLILQVHDELVVDTYKDELELVKEILKENMENVIKLKVPLVVEIGVGPNWFLAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
polA YP_281523.1 DNA polymerase I Not tested Not named Protein 2e-160 41