Gene Information

Name : speA (spyM18_0393)
Accession : NP_606642.1
Strain : Streptococcus pyogenes MGAS8232
Genome accession: NC_003485
Putative virulence/resistance : Virulence
Product : exotoxin type A
Function : -
COG functional category : -
COG ID : -
EC number : -
Position : 331557 - 332312 bp
Length : 756 bp
Strand : -
Note : best blastp match sp|P08095|SPEA_STRPY EXOTOXIN TYPE A PRECURSOR (SCARLET FEVER TOXIN) (ERYTHROGENIC TOXIN) (SPE A)

DNA sequence :
ATGGAAAACAATAAAAAAGTATTGAAGAAAATGGTATTTTTTGTTTTAGTGACATTTCTTGGACTAACAATCTCGCAAGA
GGTATTTGCTCAACAAGACCCCGATCCAAGCCAACTTCACAGATCTAGTTTAGTTAAAAACCTTCAAAATATATATTTTC
TTTATGAGGGTGACCCTGTTACTCACGAGAATGTGAAATCTGTTGATCAACTTTTATCTCACGATTTAATATATAATGTT
TCAGGGCCAAATTATGATAAATTAAAAACTGAACTTAAGAACCAAGAGATGGCAACTTTATTTAAGGATAAAAACGTTGA
TATTTATGGTGTAGAATATTACCATCTCTGTTATTTATGTGAAAATGCAGAAAGGAGTGCATGTATCTACGGAGGGGTAA
CAAATCATGAAGGGAATCATTTAGAAATTCCTAAAAAGATAGTCGTTAAAGTATCAATCGATGGTATCCAAAGCCTATCA
TTTGATATTGAAACAAATAAAAAAATGGTAACTGCTCAAGAATTAGACTATAAAGTTAGAAAATATCTTACAGATAATAA
GCAACTATATACTAATGGACCTTCTAAATATGAAACTGGATATATAAAGTTCATACCTAAGAATAAAGAAAGTTTTTGGT
TTGATTTTTTCCCTGAACCAGAATTTACTCAATCTAAATATCTTATGATATATAAAGATAATGAAACGCTTGACTCAAAC
ACAAGCCAAATTGAAGTCTACCTAACAACCAAGTAA

Protein sequence :
MENNKKVLKKMVFFVLVTFLGLTISQEVFAQQDPDPSQLHRSSLVKNLQNIYFLYEGDPVTHENVKSVDQLLSHDLIYNV
SGPNYDKLKTELKNQEMATLFKDKNVDIYGVEYYHLCYLCENAERSACIYGGVTNHEGNHLEIPKKIVVKVSIDGIQSLS
FDIETNKKMVTAQELDYKVRKYLTDNKQLYTNGPSKYETGYIKFIPKNKESFWFDFFPEPEFTQSKYLMIYKDNETLDSN
TSQIEVYLTTK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
seb AAL04126.1 Seb Virulence SaPI3 Protein 1e-47 49
seb YP_185778.1 enterotoxin B Virulence vSa1 Protein 2e-47 49
sec3 NP_372533.1 enterotoxin typeC3 Virulence vSa4 Protein 2e-47 48
sec3 NP_375118.1 enterotoxin C Virulence vSa4 Protein 2e-47 48
sec-bov AAG29599.1 staphylococcal enterotoxin C-bovine Virulence SaPIbov Protein 4e-47 48
sec-bov YP_415865.1 enterotoxin C-bovine Not tested SaPIbov Protein 5e-47 48
sec-ov YP_005735946.1 staphylococcal enterotoxin C-ovine Virulence SaPI1 Protein 1e-45 47
sec4 NP_645576.1 enterotoxin type C precursor Virulence vSa3 Protein 3e-47 47
unnamed AAL26674.1 enterotoxin-like protein Virulence SCCcap1 Protein 1e-46 46
seg NP_374931.1 extracellular enterotoxin type G Virulence vSa¥â Protein 1e-38 45
SAMSHR1132_16710 YP_005326179.1 enterotoxin Virulence vSa¥â Protein 3e-38 45
seg NP_372348.1 extracellular enterotoxin type G Virulence vSa¥â Protein 1e-38 45
SAMSHR1132_16730 YP_005326181.1 enterotoxin Virulence vSa¥â Protein 3e-43 43
seo NP_372354.1 enterotoxin Virulence vSa¥â Protein 4e-24 41
seo NP_374937.1 enterotoxin SeO Virulence vSa¥â Protein 4e-24 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
speA NP_606642.1 exotoxin type A VFG0951 Protein 2e-105 99
speA NP_606642.1 exotoxin type A VFG1802 Protein 7e-48 49
speA NP_606642.1 exotoxin type A VFG1804 Protein 1e-47 48
speA NP_606642.1 exotoxin type A VFG1805 Protein 8e-47 47
speA NP_606642.1 exotoxin type A VFG0954 Protein 2e-38 46