Gene Information

Name : spyM18_0184 (spyM18_0184)
Accession : NP_606485.1
Strain : Streptococcus pyogenes MGAS8232
Genome accession: NC_003485
Putative virulence/resistance : Unknown
Product : DNA polymerase I
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0749
EC number : -
Position : 172725 - 175367 bp
Length : 2643 bp
Strand : +
Note : has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair

DNA sequence :
ATGGAAAACAAGAATAAATTACTATTAATTGATGGCTCATCTGTTGCCTTTCGTGCCTTTTTTGCCCTTTACAATCAAAT
TGACCGCTTTAAAAACCATAGCGGTCTTCATACCAATGCCATTTATGGCTTTCATTTGATGCTAGACCACATGATGAAAA
GAGTCCGGCCTACTCACGTGCTGGTGGCTTTTGATGCGGGCAAAACCACCTTCCGAACAGAAATGTATGCCGATTATAAG
GCGGGTCGCGCTAAAACCCCAGATGAATTTCGTGAGCAGTTTCCTTATATTCGTGAGATGTTGACAGCCCTTGGGATTGC
TTATTATGAGTTGGAACACTACGAAGCAGACGATATTATCGGGACGCTTGATAAAATGGCGGAGCGCACAGAAGTGCCTT
TTGATGTGACCATTGTCAGTGGTGATAAAGATTTGATCCAGTTAACTGACGAAAATACCGTGGTTGAAATTTCTAAAAAA
GGGGTTGCCGAATTTGAAGAATTCACACCGGCTTACCTCATGGAAAAAATGGGCTTGACGCCAAACCAGTTTATTGACCT
CAAAGCCTTGATGGGAGATAAATCGGATAACATTCCTGGAGTGACAAAAATTGGAGAAAAAACAGGCCTTAAGCTCCTTC
ATGAATTTGGTAGTTTGGAAGGCATTTACGAGCATATTGATGGATTCAAGGCCTCAAAAATGAAAGAAAACTTGATCAAT
GACCGTGACCAAGCTTTCCTATCTAAAACGCTCGCCACTATCAATACAGCATCTCCTATCACAATTGGCTTAGATGATAT
TGTCTACAATGGTCCAGATGTTGCTAGCCTCTCTCAATTTTACGATGAGATGGATTTTGTGCAACTCAAGAAAGGTCTTG
CTAGCCAGATGCCTCAAGAGCCAGTAGCTGCCATTTCCTATCAAGAAGTGACCAATGTGTCTGCTGATTTGTTTAGCGCA
GAAGACATCTTCTACTTTGAAACGCTTCGGGATAATTACCATCGTGAGGCCATCATTGGTTTTGCTTGGGGACATGGTGA
GCAGATTTACGCATCCACTGACCTTAGCCTATTAGCGACGGATAGTTTTAAGCAGGTCTTCCAAAAACCCATTGCCACTT
ATGATTTTAAACGTAGCAAGGTCTTGTTGAGCCACTTAGGAATTGAGTTGGTAGCACCTAGCTATGATGCTAGATTAGCT
AATTACCTTCTGTCAACTGTAGAAGACAATGAGCTTAGCACCATTGCCCGCATTTTTACTGACATCTCTTTGGAAGAAGA
CGATACAGTCTATGGTAAAGGTGCTAAACGGGCTGTTCCTGATAAAGACGTTTTACTAGAACACTTAGCTCGTAAGGTCA
AAGTATTATTAGATAGCAAGTCTCAAATGCTAGACAAGCTCACTGCCCATGAGCAACTAGACCTCTATCAGAATATTGAA
TTGCCTTTGGCTAATGTCCTTGCTAAAATGGAAATTGAAGGGATCAAGGTTAATAGGGCGACTTTGCAAGATATGGCAGA
GCAAAACAAGGTCATTATTGAAGCGCTCACCCAAGAGATTTATGATATGGCTGGCCAAGAATTTAACATTAATTCGCCTA
AACAGCTGGGCAGTATCTTGTTTGAGAAGATGCAACTACCTCTTGAGATGACTAAGAAGACCAAAACAGGTTATTCTACA
GCTGTTGATGTTTTGGAACGTTTGGCACCGATTGCTCCAATTGTGGCTAAAATTTTGGATTACCGCCAGATTACTAAATT
GCAATCCACCTATGTGATTGGTTTACAGGATTATATTCTGGCTGATGGCAAGATTCATACCCGCTATGTGCAGGATCTCA
CCCAGACAGGGCGTTTGTCTAGTGTGGACCCTAATCTTCAAAACATTCCCATTCGTTTGGAACAGGGGCGTTTGATTCGT
AAGGCCTTTACCCCATCTCATGAAGATGCCGTCTTGTTGGGTTCAGATTACTCACAGATTGAATTGCGGGTACTGGCACA
TATTTCAGGGGATGAGCATTTGATTGCTGCCTTTAATGAAGGGGCAGACATTCATACCTCAACGGCTATGCGTGTGTTTG
GGATTGACAAGGCAGCAGATGTTACTGCCAATGACCGCCGTAATGCCAAGGCTGTTAACTTTGGAATTGTATATGGGATT
TCTGATTTTGGTTTGTCAAATAACCTTGGTATCACCCGTAAACAGGCCAAGTCTTACATTGATACCTATTTTGAACGCTA
TCCTGGGATTAAAGCCTATATGGAAAATGTGGTGCGTGAGGCTAAAGACAAGGGCTATGTAGAGACCCTCTTTAAGCGTC
GTCGTGAATTACCGGATATCAACTCTCGTAATTTCAACGTTCGCTCTTTTGCGGAGCGTACAGCCATCAACTCGCCCATT
CAAGGAAGCGCAGCTGATATTCTCAAAATCGCTATGATTAATCTGGATAAGGCCTTGCAAGCAGGTGGTTTTAGAGCTAA
AATGCTGCTTCAAGTGCATGATGAAATCGTTTTGGAAGTGCCAAATGATGAGTTGACTGCTATAAAAAAACTTGTCAAAG
ACACCATGGAAGCTGCTGTTGATTTAGCTGTTCCTTTATGTGTCGATGAAAGTACTGGGCAGAGCTGGTACGAAGCCAAA
TAA

Protein sequence :
MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHVLVAFDAGKTTFRTEMYADYK
AGRAKTPDEFREQFPYIREMLTALGIAYYELEHYEADDIIGTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKK
GVAEFEEFTPAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKASKMKENLIN
DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQEPVAAISYQEVTNVSADLFSA
EDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLA
NYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE
LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYST
AVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIR
KAFTPSHEDAVLLGSDYSQIELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI
SDFGLSNNLGITRKQAKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINSPI
QGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
polA YP_281523.1 DNA polymerase I Not tested Not named Protein 0.0 99