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Name : leuS (spyM18_0171) Accession : NP_606474.1 Strain : Streptococcus pyogenes MGAS8232 Genome accession: NC_003485 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 158325 - 160826 bp Length : 2502 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGACATTTTACGATCACACCGCTATTGAACCCAAATGGCAAGCCTTTTGGGCAGATAATCACACCTTTAAAACAGGAAC AGACGCATCAAAACCTAAGTTTTATGCCCTAGATATGTTCCCATACCCATCAGGAGCTGGTCTCCACGTTGGTCACCCAG AAGGCTATACAGCAACTGATATTCTTAGCCGTTTCAAACGTGCCCAAGGTCACAATGTCCTCCACCCAATGGGGTGGGAT GCCTTTGGACTTCCTGCTGAGCAGTACGCTATGGATACTGGTAATGATCCAGCCGAGTTTACAGCTGAAAACATCGCTAA CTTCAAACGCCAGATTAATGCTCTTGGCTTCTCATACGACTGGGACCGTGAAGTTAACACAACTGACCCTAACTACTACA AGTGGACGCAGTGGATCTTTACCAAGCTTTATGAAAAAGGTCTAGCCTACGAAGCTGAAGTTCCTGTTAACTGGGTTGAA GAATTGGGAACAGCTATCGCCAACGAAGAGGTTCTTCCAGATGGGACATCAGAGCGTGGCGGCTACCCAGTTGTCAGAAA ACCCATGCGCCAATGGATGCTCAAAATCACTGCCTATGCAGAGCGCTTGCTAGAAGACTTGGAAGAAGTTGACTGGCCAG AATCAATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGTGCTAATGTAACCTTCAAGGTTAAGGATACAGAT AAGGACTTCACTGTCTTCACAACACGTCCTGACACGCTTTTTGGTGCAACTTACGCGGTTCTTGCTCCTGAGCATGCCTT GGTTGATGCTATTACGACAGCTGACCAGGCAGAAGCCGTTGCTGACTACAAACGTCAAGCAAGTCTCAAATCAGACCTTG CTCGTACAGACCTTGCCAAAGAAAAAACAGGTGTTTGGACGGGTAGCTACGCTATTAACCCAGTTAATGGTAACGAAATG CCAGTTTGGATTGCGGACTATGTCCTTGCTAGCTACGGTACTGGAGCTATCATGGCTGTTCCAGCCCACGATGAACGTGA CTGGGAATTCGCAAAACAATTTAACCTAGACATCATCCCTGTTCTTGAAGGTGGCAATGTTGAAGAGGCTGCCTTTACAG AAGACGGTCTTCACATCAACTCAGGCTTCCTAGATGGTCTTGACAAAGCGTCAGCTATTGCCAAAATGGTCGAATGGCTT GAAGCAGAAGGCGTCGGTAATGAAAAAGTCACTTACCGTCTCCGTGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA GCCAATCCCAATTATCCACTGGGAAGATGGTACATCAACAGCGGTTCCTGAGAGTGAATTGCCATTGGTTCTTCCAGTAA CTAAGGATATTCGTCCTTCAGGTACTGGTGAGAGCCCGCTTGCTAACGTGACAGACTGGTTGGAAGTTACCCGTGAAGAT GGTGTTAAAGGTCGTCGTGAGACTAACACCATGCCACAATGGGCAGGTTCAAGCTGGTACTACCTCCGTTACATCGATCC ACACAACACCGAAAAACTGGCTGATGAGGAACTCCTCAAACAATGGTTGCCAGTTGATATCTATGTCGGTGGTGCAGAGC ATGCCGTGCTTCACCTTCTCTACGCTCGCTTCTGGCACAAGGTTCTTTACGATCTCGGTGTTGTACCTACCAAAGAGCCA TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGGACAAGCTACCGCGATAGCCGTGGAGCGCTTGTAGCGACTGACAA GGTTGAAAAACGTGATGGCAGCTTCTTCCATTTGGAAACTGGTGAAGAGCTTGAACAAGCACCAGCTAAGATGTCTAAAT CACTTAAGAACGTTGTCAACCCAGATGATGTTGTTGAGCAGTACGGTGCTGACACCCTTCGTGTTTACGAGATGTTCATG GGACCACTTGACGCTTCCATCGCTTGGTCTGAAGAAGGTCTTGAAGGCTCACGTAAGTTCTTGGACCGTGTTTACCGTTT GGTAACGACTAAGGAGATTGTGGCGGAAAATAGCGGTGCCTTGGATAAAGTTTACAACGAAACTGTTAAGGCTGTTACTG AGCAAGTTGACCAAATGAAATTCAACACAGCTATCGCTCAACTCATGGTATTTGTCAATGCAGCCAACAAGGAAGACAAA CTCTTTAGCGACTATGCCAAAGGCTTTGTTCAATTGATTGCACCATTTGCACCGCACTTAGGTGAGGAACTCTGGCAAGC CTTGACAGCCTCAGGTGAGTCAATCTCTTACGTGCCATGGCCAAGTTATGATGAAAGCAAATTGGTTGAAAACGATGTGG AAATCGTTGTCCAAATCAAAGGTAAGGTCAAAGCTAAACTTGTAGTTGCCAAAGACCTTTCACGCGAAGAATTGCAAGAA GTTGCCCTTGCTAACGAAAAAGTCCAAGCCGAAATCGCAGGCAAAGACATCATCAAAGTCATCGCAGTACCAAACAAACT CGTTAATATTGTTATCAAATAG Protein sequence : MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWD AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTD KDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGNEM PVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSGFLDGLDKASAIAKMVEWL EAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTRED GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP FQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHLETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM GPLDASIAWSEEGLEGSRKFLDRVYRLVTTKEIVAENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDK LFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQE VALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 0.0 | 99 |
