Gene Information

Name : nrdE (spyM18_1387)
Accession : NP_607483.1
Strain : Streptococcus pyogenes MGAS8232
Genome accession: NC_003485
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 1159614 - 1161773 bp
Length : 2160 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGAGTCTCAAAGATCTTGGCGATATTTCATATTTTCGCCTAAATAATGAAATTAACCGTCCTGTTAATGGTAAAATTCC
ACTTCATAAAGACAAAGAAGCTTTAAAAGCTTTTTTCGCTGAAAATGTGCTGCCAAACACCATGTCTTTTACTTCCATTA
CGGAAAAAATTGAGTATTTAATCTCAAATGATTACATTGAATCAGCTTTTATTCATAAATACCACCCTGAATTTATTACT
GAATTAGCTAGCGTAATCAAATCAGAAAATTTTCGCTTTAAATCATTTATGGCAGCCTACAAGTTCTACCAGCAATACGC
CTTAAAAACAAATGATGGAGAGCATTATTTAGAAAACCTTGAAGACCGTGTCTTGTTTAATGCTTTGTATTTTGCAGATG
GTCAAGAAGACTTAGCAAAAGATTTAGCCGTTGAAATGATTAACCAACGTTACCAACCGGCTACTCCTTCCTTTTTAAAT
GCTGGTCGAAGCCGTCGTGGTGAATTGGTCTCTTGTTTCTTGATTCAAGTAACTGATGACATGAACTCTATCGGACGTTC
TATCAACTCTGCTTTGCAATTATCCCGTATTGGTGGAGGTGTTGGGATTACCTTGTCTAACCTCCGTGAAGCTGGCGCAC
CAATCAAAGGCTATGCTGGTGCAGCCTCAGGAGTTGTTCCTGTTATGAAATTATTTGAAGATAGTTTTTCTTATTCAAAT
CAACTTGGGCAACGTCAAGGAGCTGGTGTTGTTTACCTAAATGTTTTTCATCCTGATATCATTGCTTTCTTATCTACTAA
AAAAGAAAATGCCGATGAAAAGGTGCGTGTTAAAACCTTGTCACTAGGGATTACCGTTCCTGATAAATTCTACGAATTAG
CTCGTAAAAACGAGGACATGTATCTCTTTAGTCCTTACAATGTTGAAAAAGAATATGGCATTCCCTTTAACTATCTCGAC
ATTACCAATATGTACGATGAGTTAGTGGCGAACCCTAAAATTACTAAGACTAAAATTAAAGCTCGTGATCTTGAAACAGA
GATTTCAAAATTACAACAAGAATCTGGTTACCCTTATATTATCAATATTGATACAGCTAATAAAGCTAATCCTATCGATG
GAAAAATCATCATGAGCAACTTGTGTTCTGAAATTTTACAAGTTCAAACACCTAGCCTTGTCAATGATGCGCAAGAGTTT
GTAGAAATGGGAACTGATATTTCATGTAACTTAGGTTCCACTAATATCCTAAACATGATGACCTCACCAGACTTTGGCCG
TTCTATTAAGACCATGACACGTGCCCTAACTTTTGTTACTGATTCATCAAGCATTGAAGCTGTTCCAACCATTAAACATG
GTAACAGCCAAGCACATACTTTTGGCCTTGGAGCTATGGGACTACATTCTTACCTTGCTCAACATCATATTGAATATGGC
AGTCCAGAATCCATCGAGTTCACTGATATTTACTTTATGCTCTTGAATTATTGGACCTTGGTCGAATCCAATAACATCGC
TCGTGAGCGCCAAACTACCTTTGTTGGCTTTGAGAACTCTAAGTACGCTAATGGTAGTTACTTTGATAAATACGTTACAG
GACACTTTGTTCCAAAATCTGATTTGGTGAAAGATCTGTTCAAAGACCATTTTATTCCGCAAGCTTCAGATTGGAAGGCT
CTTCGCGACGCCGTTCAAAAAGATGGTCTTTATCATCAAAACCGTCTAGCAGTTGCTCCAAATGGCTCTATTTCTTATAT
CAATGACTGCTCTGCTTCTATTCACCCAATCACACAAAGAATTGAAGAACGTCAAGAAAAGAAAATTGGTAAAATCTACT
ATCCTGCAAATGGTTTGTCTACGGATACCATTCCTTACTATACATCTGCTTACGATATGGACATGCGCAAAGTTATTGAT
GTCTATGCCGCTGCGACCGAACATGTGGACCAAGGCTTGTCATTAACTCTATTCCTTCGTAGTGAGTTGCCTATGGAGCT
TTATGAGTGGAAAACACAAAGCAAACAAACCACTCGTGATTTATCCATCTTACGAAACTACGCTTTCAATAAAGGCATTA
AATCTATCTACTATATCCGTACCTTTACGGATGATGGGGAAGAAGTGGGCGCAAACCAATGTGAATCTTGTGTCATTTAA

Protein sequence :
MSLKDLGDISYFRLNNEINRPVNGKIPLHKDKEALKAFFAENVLPNTMSFTSITEKIEYLISNDYIESAFIHKYHPEFIT
ELASVIKSENFRFKSFMAAYKFYQQYALKTNDGEHYLENLEDRVLFNALYFADGQEDLAKDLAVEMINQRYQPATPSFLN
AGRSRRGELVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYAGAASGVVPVMKLFEDSFSYSN
QLGQRQGAGVVYLNVFHPDIIAFLSTKKENADEKVRVKTLSLGITVPDKFYELARKNEDMYLFSPYNVEKEYGIPFNYLD
ITNMYDELVANPKITKTKIKARDLETEISKLQQESGYPYIINIDTANKANPIDGKIIMSNLCSEILQVQTPSLVNDAQEF
VEMGTDISCNLGSTNILNMMTSPDFGRSIKTMTRALTFVTDSSSIEAVPTIKHGNSQAHTFGLGAMGLHSYLAQHHIEYG
SPESIEFTDIYFMLLNYWTLVESNNIARERQTTFVGFENSKYANGSYFDKYVTGHFVPKSDLVKDLFKDHFIPQASDWKA
LRDAVQKDGLYHQNRLAVAPNGSISYINDCSASIHPITQRIEERQEKKIGKIYYPANGLSTDTIPYYTSAYDMDMRKVID
VYAAATEHVDQGLSLTLFLRSELPMELYEWKTQSKQTTRDLSILRNYAFNKGIKSIYYIRTFTDDGEEVGANQCESCVI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 3e-178 51