Gene Information

Name : spyM18_1346 (spyM18_1346)
Accession : NP_607448.1
Strain : Streptococcus pyogenes MGAS8232
Genome accession: NC_003485
Putative virulence/resistance : Unknown
Product : nicotinate-nucleotide pyrophosphorylase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0157
EC number : 2.4.2.19
Position : 1122250 - 1123122 bp
Length : 873 bp
Strand : -
Note : catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide

DNA sequence :
ATGTCAATCATTTCAACTGATTTAACCCCTTTTCAAATAGATGATACATTGAAAGCAGCCTTGCGAGAAGATGTTCATTC
CGAAGATTACAGTACCAATGCCATTTTTGATCATCATGGCCAAGCCAAGGTGTCGCTTTTTGCCAAGGAAGCTGGTGTTT
TAGCGGGGCTAACCGTTTTTCAAAGGGTTTTTACCCTATTTGATGCCGAGGTGACCTTCCAGAATCCTCATCAATTTAAG
GATGGGGATCGTTTGACTAGTGGCGATTTGGTTTTAGAAATCATAGGCTCGGTGAGAAGCCTCTTAACATGTGAACGCGT
TGCCTTGAATTTTTTACAACATTTATCAGGGATTGCTTCGATGACAGCTGCTTATGTAGAAGCCTTAGGCGATGATCGCA
TTAAGGTATTTGATACTCGAAAAACCACTCCTAATTTACGTCTTTTTGAGAAATATGCCGTGAGAGTTGGCGGTGGCTAT
AATCATCGCTTTAATTTATCAGATGCTATCATGCTAAAAGACAATCACATTGCGGCAGTAGGTAGTGTTCAAAAGGCGAT
TGCTCAAGCGCGTGCCTATGCCCCTTTTGTGAAAATGGTCGAGGTGGAAGTGGAAAGCCTTGCTGCTGCCGAAGAAGCTG
CGGCGGCGGGTGTTGATATTATCATGTTGGATAATATGTCATTGGAACAGATTGAACAGGCCATTACTCTAATTGCAGGA
CGTTCTCGGATTGAATGTTCTGGAAATATTGATATGACCACTATTAGCCGTTTTCGTGGTTTAGCGATTGATTACGTCTC
CAGTGGTAGTTTAACCCATAGTGCTAAGAGTCTCGATTTTTCCATGAAGGGTTTAACCTACCTTGATGTCTAA

Protein sequence :
MSIISTDLTPFQIDDTLKAALREDVHSEDYSTNAIFDHHGQAKVSLFAKEAGVLAGLTVFQRVFTLFDAEVTFQNPHQFK
DGDRLTSGDLVLEIIGSVRSLLTCERVALNFLQHLSGIASMTAAYVEALGDDRIKVFDTRKTTPNLRLFEKYAVRVGGGY
NHRFNLSDAIMLKDNHIAAVGSVQKAIAQARAYAPFVKMVEVEVESLAAAEEAAAAGVDIIMLDNMSLEQIEQAITLIAG
RSRIECSGNIDMTTISRFRGLAIDYVSSGSLTHSAKSLDFSMKGLTYLDV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nadC YP_281534.1 nicotinate-nucleotide pyrophosphorylase Not tested Not named Protein 6e-124 100