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Name : pyk (spyM18_1230) Accession : NP_607341.1 Strain : Streptococcus pyogenes MGAS8232 Genome accession: NC_003485 Putative virulence/resistance : Virulence Product : pyruvate kinase Function : - COG functional category : G : Carbohydrate transport and metabolism COG ID : COG0469 EC number : 2.7.1.40 Position : 1032163 - 1033665 bp Length : 1503 bp Strand : - Note : catalyzes the formation of phosphoenolpyruvate from pyruvate DNA sequence : ATGAATAAACGCGTAAAAATCGTTGCAACACTTGGTCCTGCGGTTGAAATCCGTGGTGGTAAAAAATACGGAGAAGATGG CTACTGGGCTGGTCAACTTGATGTTGAAGAATCAGCAAAAAAAATTGCTGAATTAATTGAAGCTGGTGCGAATGTTTTCC GTTTCAATTTCTCACATGGTGACCACAAAGAACAAGGTGACCGTATGGCAACTGTTCGCCTTGCAGAAGAAATTGCTCGT CAAAAAGTTGGTTTCCTTTTGGATACTAAAGGTCCTGAAATGCGTACGGAATTGTTTGCAGATGATGCTAAAGAATTCAG CTATGTCACTGGAGAAAAAATCCGTGTAGCGACTACACAAGGTATTCAATCAACTCGCGATGTTATTGCTTTGAACGTTG CTGGTAGTCTTGACATCTACGATGAAGTAGAAGTAGGTCATACTATTCTTATCGATGATGGTAAACTTGGTTTGAAAGTG ATCGACAAAGATATCGCAACACGTCAATTTATCGTTGAAGTAGAAAACGACGGTATTATTGCTAAACAAAAAGGTGTTAA TATCCCTAACACTAAAATTCCTTTCCCAGCACTTGCGGAACGCGACAATGCTGATATCCGTTTTGGTCTTGAACAAGGAC TTAACTTTATTGCAATCTCATTTGTTCGTACAGCCAAAGACGTTGAGGAAGTTCGTGAAATCTGTCGCGAAACTGGTAAC GACCATGTGCAATTATTTGCTAAGATTGAAAACCAACAAGGTATCGATAATCTTGATGAAATCATCGAAGCTGCTGATGG TATCATGATTGCACGTGGCGACATGGGTATCGAAGTACCATTTGAAATGGTTCCAGTTTTCCAAAAAATGATTATCACTA AAGTGAATGCAGCTGGTAAAGCAGTTATCACAGCAACAAACATGCTTGAAACAATGACTGAAAAACCACGTGCGACACGT TCTGAAGTATCTGACGTCTTCAATGCTGTTATCGATGGTACTGATGCAACAATGCTTTCAGGAGAGTCAGCTAACGGTAA ATACCCGGTTGAATCTGTTCGTACAATGGCGACTATTGATCGTAATGCACAAACTCTTCTTAACGAATATGGTCGTTTAG ATTCATCTGCCTTTCCACGTACCAATAAAACAGATGTTATTGCTTCAGCTGTTAAAGATGCCACTCATTCAATGGACATT AAACTTGTTGTGACTATTACTGAGACAGGTAATACAGCTCGTGCGATTTCTAAATTCCGTCCAGATGCGGACATCTTAGC TGTAACATTTGATGAAAAAGTACAACGTGCTTTGATGATTAACTGGGGTGTTATTCCTGTTCTTGCTGAAAAACCTGCAT CTACTGATGACATGTTTGAAGTAGCAGAGCGTGTTGCTGTGGAGGCAGGCTTAGTTCAATCTGGGGATAATATTGTTATT GTTGCTGGTGTTCCAGTTGGTACTGGTGGAACGAATACTATGCGTGTTCGTACAGTAAAATAA Protein sequence : MNKRVKIVATLGPAVEIRGGKKYGEDGYWAGQLDVEESAKKIAELIEAGANVFRFNFSHGDHKEQGDRMATVRLAEEIAR QKVGFLLDTKGPEMRTELFADDAKEFSYVTGEKIRVATTQGIQSTRDVIALNVAGSLDIYDEVEVGHTILIDDGKLGLKV IDKDIATRQFIVEVENDGIIAKQKGVNIPNTKIPFPALAERDNADIRFGLEQGLNFIAISFVRTAKDVEEVREICRETGN DHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVFQKMIITKVNAAGKAVITATNMLETMTEKPRATR SEVSDVFNAVIDGTDATMLSGESANGKYPVESVRTMATIDRNAQTLLNEYGRLDSSAFPRTNKTDVIASAVKDATHSMDI KLVVTITETGNTARAISKFRPDADILAVTFDEKVQRALMINWGVIPVLAEKPASTDDMFEVAERVAVEAGLVQSGDNIVI VAGVPVGTGGTNTMRVRTVK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| STY1744 | NP_456147.1 | pyruvate kinase | Not tested | SPI-2 | Protein | 1e-80 | 43 |
| pykF | YP_216386.1 | pyruvate kinase | Not tested | SPI-2 | Protein | 5e-81 | 43 |
| pykF | NP_805051.1 | pyruvate kinase | Not tested | SPI-2 | Protein | 5e-81 | 43 |
| pykF | CAA68205.1 | pyruvate kinase like protein | Not tested | SPI-2 | Protein | 3e-81 | 43 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| pyk | NP_607341.1 | pyruvate kinase | VFG0479 | Protein | 2e-81 | 43 |
