Gene Information

Name : ureC (NCgl0085)
Accession : NP_599338.1
Strain : Corynebacterium glutamicum ATCC 13032
Genome accession: NC_003450
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 91992 - 93704 bp
Length : 1713 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAGTTTTGAGATTTCCCGCAAGCAGTACACCGACCTTTATGGTCCAACCGTTGGCGATTCAGTACGTCTTGCTGATAC
TGAGCTTTTTCTCTGTGTGGAAAAAGATTACGCAGCAATCGGCGAAGAAGTAGCATTCGGCGGTGGCAAGGTCATTCGTG
ATGGCATGGGCCAAAATGGCACCTTGGTTCGCGATGTAGATATTCCCGATACCGTCATCACCAACGTCATCGTCCTTGAC
TATACGGGTGTGTACAAAGCTGACGTTGCGCTTCGAGATGGCAAAATCTTCCGAATCGGAAAGGCCGGAAACCCGAATGT
CATGGAAAACGTCGACATCGTCATCGGCGTTGCCACCGACATCATTGCTGGTGAAGGCAAAATCCTTACCGCAGGTGGCA
TCGACACGCACGTGCACTTCTTGGGCACAGACCAGGTCAACACTGCATTAGCATCAGGTATCACCACGATGATCGGTGGA
GGCACCGGCCCAAGCCAGGCGTCGATGGCTACAACTGTCACGCCAGGTCAGTGGAATACCTACAACATGCTTAGTGCTTT
TGAAGGCATGCCCATGAACTTTGGCATTTTGGGTAAAGGCCATGGTTCTTCCAAATCTCCGCTGGCTGAGCAGGTTCGTG
CGGGTGCAATCGGTCTGAAAATTCACGAGGACTGGGGTGCCACACCATCGTCGATCAACACTGCCCTAGAAGTAGCCGAT
GACATGGACATCCAGGTGGCACTCCACTCCGATACCTTGAATGAGGCCGGTTTTGTGGAAGACACCATTGAAGCCATTGC
GGGCCGAGTCATCCATACCTTCCACACCGAAGGTGCTGGTGGTGGACACGCTCCTGACCTAATCCGAGTGGCTGCTCTGC
CAAACGTGTTGCCTGCATCCACCAACCCAACGCTCCCATACACCCGAAACACTGTTGAAGAGCACCTGGACATGGTGATG
GTTGCCCACCACCTCAACCCAGATATTCCAGAAGACGTGGCTTTTGCGGATTCCCGAATTCGTGCCGAAACGATTGCAGC
CGAAGATGTGCTTCACGATATGGGTATCTTCTCTATCACCTCTTCGGATTCCCAGGCGATGGGCCGAGTAGGAGAGACCA
TCACGCGCACGTGGCAGGTCGCCGACCATATGAAACGCACCCGTGGATCACTAACGGGAGATGCTCCATACAACGACAAC
AACCGCTTGCGTCGATTCATCGCAAAATACACCATCAACCCTGCGATTGCGCACGGTGTGGATTATGTTGTCGGTTCAGT
GGAGGAAGGCAAGTTCGCTGACCTCGTGCTGTGGGATCCAAAGTTCTTTGGTGTGAAACCTGATCTGGTGATCAAGGGTG
GGTTGATGGTCAATTCCCTCATGGGTGATTCCAACGGTTCCATTCCAACTCCGCAGCCCCGCACCCTGCGCAATACTTGG
GGTGCGTTTGGCCAGGCAGTTTCCAGAAGCTCCATTACATTCCTATCCCAGGACGCTATCGATGCAAATGTTCCTGATCT
GCTGAATCTGAGGAAGCAGATCCGGGGCGTTCGAGGTGTAAGGAATCTGACCAAACGAGACATGAAACTCAATGCAGAAA
TGCCTGATATTCGTGTCGATCCAGAGACCTACCAGGTGTTTGTCAACGGTGAGTTGATCACCAGCAAGCCAGCAGAGACA
GTGCCAATGGCACGTCGCTACTTCTTGTTCTAA

Protein sequence :
MSFEISRKQYTDLYGPTVGDSVRLADTELFLCVEKDYAAIGEEVAFGGGKVIRDGMGQNGTLVRDVDIPDTVITNVIVLD
YTGVYKADVALRDGKIFRIGKAGNPNVMENVDIVIGVATDIIAGEGKILTAGGIDTHVHFLGTDQVNTALASGITTMIGG
GTGPSQASMATTVTPGQWNTYNMLSAFEGMPMNFGILGKGHGSSKSPLAEQVRAGAIGLKIHEDWGATPSSINTALEVAD
DMDIQVALHSDTLNEAGFVEDTIEAIAGRVIHTFHTEGAGGGHAPDLIRVAALPNVLPASTNPTLPYTRNTVEEHLDMVM
VAHHLNPDIPEDVAFADSRIRAETIAAEDVLHDMGIFSITSSDSQAMGRVGETITRTWQVADHMKRTRGSLTGDAPYNDN
NRLRRFIAKYTINPAIAHGVDYVVGSVEEGKFADLVLWDPKFFGVKPDLVIKGGLMVNSLMGDSNGSIPTPQPRTLRNTW
GAFGQAVSRSSITFLSQDAIDANVPDLLNLRKQIRGVRGVRNLTKRDMKLNAEMPDIRVDPETYQVFVNGELITSKPAET
VPMARRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 1e-168 63
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 1e-168 63
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-176 63
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-178 63
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-178 63
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-178 63

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC NP_599338.1 urease subunit alpha VFG0270 Protein 6e-146 59