Gene Information

Name : guaA (NCgl0582)
Accession : NP_599843.1
Strain : Corynebacterium glutamicum ATCC 13032
Genome accession: NC_003450
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 620004 - 621575 bp
Length : 1572 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAGCCTTCAGACAAATCATCGCCCAGTACTCGTCGTTGACTTCGGCGCACAGTACGCGCAGCTGATCGCACGTCGTGT
GCGTGAGGCCGGCATCTACTCCGAAGTCATCCCGCACACCGCCACCGCAGACGATGTGCGCGCTAAAAATGCAGCAGCCC
TCGTCCTTTCCGGTGGCCCATCCTCCGTGTATGCCGAGGGAGCACCATCCCTTGACGCTGAGATTCTTGATCTCGGATTG
CCAGTATTTGGCATTTGCTACGGCTTCCAAGCCATGACCCACGCGCTTGGTGGCACCGTTGCCAACACCGGTAAGCGCGA
ATACGGACGCACCGACATCAACGTTGCCGGTGGCGTCCTCCACGAAGGCCTCGAAGCCTGCCACAAGGTGTGGATGAGCC
ACGGCGACGCCGTCTCTGAAGCCCCAGAAGGTTTCGTAGTCACCGCGTCCTCCGAAGGTGCGCCTGTCGCAGCTTTCGAA
AACAAGGAACGCAAAATGGCTGGCGTGCAGTACCACCCAGAGGTATTGCACTCACCACACGGCCAGGCAGTTCTGACCCG
CTTCCTCACTGAGATCGCAGGTCTAGAGCAGAACTGGACCGCAGCAAACATCGCTGAAGAACTCATCGAAAAGGTCCGCG
AGCAGATCGGCGAAGATGGCCGCGCTATTTGTGGCCTATCCGGTGGTGTGGACTCCGCTGTTGCCGGTGCTTTGGTGCAG
CGCGCCATTGGTGACCGTTTGACCTGTGTCTTTGTTGACCACGGTCTGCTGCGTGCCGGTGAGCGCGAGCAGGTGGAAAA
AGACTTCGTCGCAGCAACCGGCGCCAAGCTGGTTACCGTTGATGAGCGCCAGGCATTCCTATCCAAGCTGGCCGGAGTTA
CCGAACCAGAAGCAAAGCGCAAGGCTATCGGCGCTGAGTTCATCCGCTCCTTCGAGCGCGCAGTTGCCGGTGTGCTGGAA
GAAGCTCCAGAAGGTTCCACCGTGGACTTCCTGGTTCAGGGCACCCTGTACCCAGACGTCGTGGAATCCGGTGGTGGATC
TGGTACCGCAAACATCAAGAGCCACCACAACGTCGGTGGACTGCCAGACGATGTGGAATTCAAGCTTGTTGAGCCACTGC
GTGACCTCTTCAAAGACGAAGTCCGTGCCGTTGGCCGTGAACTTGGCCTGCCTGAGGAAATCGTTGGCCGCCAGCCATTC
CCAGGACCAGGACTTGGTATCCGCATCATCGGTGAAGTCACCGAAGATCGCCTAGAAACCCTCCGCCACGCTGACCTGAT
CGCCCGCACCGAGCTCACCGAAGCCGGACTTGACGGCGTGATCTGGCAGTGCCCAGTAGTCCTCCTGGCAGATGTCCGCT
CTGTTGGTGTTCAAGGCGATGGCCGCACCTACGGACACCCAATCGTGCTGCGCCCAGTGTCTTCCGAAGACGCAATGACC
GCCGACTGGACCCGCCTGCCATACGAGGTTCTGGAGAAGATCTCCACCCGCATCACCAACGAAGTTCCAGATGTGAACCG
CGTGGTGCTGGACGTAACCTCCAAGCCACCAGGAACCATCGAATGGGAGTAG

Protein sequence :
MSLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGPSSVYAEGAPSLDAEILDLGL
PVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVLHEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFE
NKERKMAGVQYHPEVLHSPHGQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQ
RAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLE
EAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPF
PGPGLGIRIIGEVTEDRLETLRHADLIARTELTEAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMT
ADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 89
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-134 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-134 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-133 52