Gene Information

Name : PF0676 (PF0676)
Accession : NP_578405.1
Strain : Pyrococcus furiosus DSM 3638
Genome accession: NC_003413
Putative virulence/resistance : Unknown
Product : carbamate kinase-like carbamoyl phosphate synthetase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0549
EC number : -
Position : 685707 - 686651 bp
Length : 945 bp
Strand : -
Note : this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable react

DNA sequence :
ATGGGTAAGAGGGTAGTGATTGCACTTGGAGGTAACGCTCTTCAGCAGCGAGGTCAAAAGGGAAGTTATGAGGAGATGAT
GGATAACGTTCGCAAGACCGCTAGGCAAATTGCCGAAATTATAGCGAGAGGGTATGAAGTTGTTATCACTCATGGAAATG
GTCCTCAAGTTGGAAGTCTTCTCCTTCATATGGATGCTGGGCAGGCAACTTATGGAATTCCCGCCCAACCAATGGATGTG
GCTGGTGCAATGAGTCAGGGATGGATTGGTTATATGATTCAGCAGGCTTTGAAGAACGAGCTGAGGAAGAGGGGCATGGA
AAAGAAAGTTGTTACAATAATTACCCAAACAATTGTTGATAAGAATGATCCAGCATTCCAAAACCCCACAAAGCCAGTGG
GGCCATTTTACGATGAAGAGACTGCAAAAAGGTTAGCCAGAGAAAAGGGATGGATAGTTAAAGAGGATTCTGGTAGAGGT
TGGAGAAGAGTAGTTCCTTCTCCAGATCCCAAAGGGCACGTTGAGGCAGAGACGATTAAAAAGTTAGTGGAAAGGGGAGT
TATAGTTATTGCAAGTGGTGGAGGAGGAGTTCCTGTAATACTTGAAGACGGGGAAATAAAGGGTGTTGAGGCCGTCATCG
ACAAGGATCTGGCAGGAGAAAAGCTTGCTGAGGAAGTAAATGCTGACATATTCATGATTCTTACAGATGTTAACGGCGCT
GCATTATACTATGGAACGGAAAAGGAGCAGTGGTTAAGGGAAGTTAAGGTCGAAGAGCTTAGGAAGTACTATGAAGAGGG
CCACTTTAAGGCGGGAAGCATGGGGCCAAAGGTTCTAGCGGCTATAAGGTTCATCGAGTGGGGTGGAGAGAGGGCCATAA
TAGCTCACCTAGAAAAGGCAGTTGAGGCTCTCGAAGGGAAGACTGGTACTCAAGTTCTCCCTTAA

Protein sequence :
MGKRVVIALGGNALQQRGQKGSYEEMMDNVRKTARQIAEIIARGYEVVITHGNGPQVGSLLLHMDAGQATYGIPAQPMDV
AGAMSQGWIGYMIQQALKNELRKRGMEKKVVTIITQTIVDKNDPAFQNPTKPVGPFYDEETAKRLAREKGWIVKEDSGRG
WRRVVPSPDPKGHVEAETIKKLVERGVIVIASGGGGVPVILEDGEIKGVEAVIDKDLAGEKLAEEVNADIFMILTDVNGA
ALYYGTEKEQWLREVKVEELRKYYEEGHFKAGSMGPKVLAAIRFIEWGGERAIIAHLEKAVEALEGKTGTQVLP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
arcC1 YP_186045.1 carbamate kinase Not tested vSa¥ã Protein 6e-57 47
MW1051 NP_645868.1 carbamate kinase Not tested vSa¥ã Protein 6e-57 47
SAV1170 NP_371694.1 carbamate kinase Not tested vSa¥ã Protein 6e-57 47
SA1013 NP_374286.1 carbamate kinase Not tested vSa¥ã Protein 6e-57 47
arcC YP_493761.1 carbamate kinase Not tested vSa¥ã Protein 6e-57 47
SAKOR_01091 YP_008491279.1 Carbamate kinase Not tested vSa¥ã Protein 4e-57 47
SE0102 NP_763657.1 carbamate kinase Not tested SCCpbp4 Protein 2e-50 46
APECO1_2636 YP_859422.2 carbamate kinase Not tested Not named Protein 3e-48 46