Gene Information

Name : clpC (CPE2441)
Accession : NP_563357.1
Strain : Clostridium perfringens 13
Genome accession: NC_003366
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence MecB/ClpC
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 2788268 - 2790712 bp
Length : 2445 bp
Strand : -
Note : similar to sp:CLPC_BACSU NEGATIVE REGULATOR OF GENETIC COMPETENCE CLPC/MECB from Bacillus subtilis (810 aa); 53.1% identity in 813 aa overlap

DNA sequence :
ATGCGTCTTGATAATTTTAATGAAAATTCCAAAATAGTAATCAATAAGGGAAAAGAAAGTTCTTTAATGCTAAAACACGG
CTACATGGGAACAGAGCATTTATTAATAGGATTAATTAATGAAAATGGACAATGTTCTAAAATTTTGGAAGAAAGCAATG
TAACTGAAGAAAAGGTACTTAGTTTTATTAAGCTATATGTTGGAATTGGAGAGGTAAATTATAGTTTAGATGAGGTGCCT
TTTACGCCTAGATGCAAAAAGATTTTAGATAGAAGTGTTGAAATTGCTAAGGAATATGGTCATAGTATTTCAAGACCAGA
GCACATATTATTAGCCTTAATAAAAGAAAGAGAAGGTGTAGCTAATTTAATTCTAACTAAAATAGTAAAAAATGATATAA
AAAATATAAGTGATAAGTTAAATAACATACTAGGTAGAATTCCAAGTAAGGAAAGTAAAAGCCTTAAGGAAAAGGAAAAA
CCAAAAAGAAAAGATACTCCTACATTAAATCTTTATGGTATAAATTTAATAGAAAGGGCAGATAAAAATAAGCTTGATCC
TGTAATAGGGAGAAAGGATGAAACTCAAAGACTTTTAGAAATACTTTGTAGAAGAATGAAAAATAATCCTTGTTTAATAG
GAGAACCTGGAGTAGGAAAAACTGCCGTTGTTGAAGGCTTAGCTCAGAGGATTTTATTAGGTGAAGTACCGGATATTATT
AAGGATAAAAGAATATTTACCTTAGATGTGACTTCTATGTTAGCTGGGGCAAAATATAGAGGAGAATTTGAGGAAAGACT
TAAAAAGGTTTTAAACGAAGTAAAAGATTCAGATGATATAATACTCTTTATAGATGAAATGCATAATATTGTTGGGGCTG
GTGGAGCAGAAGGTGCTATAGATGCATCAAATATATTAAAACCAGCTTTAGCAAGAGGTGAAATACAATGTATAGGTGCG
ACAACAACTGATGAATATAGAAAAAATATAGAAAAGGATTCTGCTTTAGAGAGAAGATTCCAACCAGTAGTTGTAAAAGA
GCCTAGTAAAGAAGATTCCGTATTAATATTAAAGGGATTAAGAGAAAAGTATGAAGTACATCACAATGTAAAATTAACAG
ATGAAGCCATAGAGGCAGCTGTTAATTTATCAAGTAGATATATAACAGATAGATTTCTACCAGATAAGGCCATAGATCTA
ATAGATGAGGCTGCGGCAAAGGTAAGAATAGAAAGTATGATTGTTCCTCCTAGACTTTTTAAGCAGGAAGAATTAATAGC
TAACTTAAAAGTTGAAAAAGAAGAAGCTATAAAATTACAGGACTTTGAATTAGCTGCAAAGTTAAGAGATGAAGAATTAA
TGTTACAGGAAGAACTAGAGCGAGATAAAGAACTTTGGAGAGAAGAAAATTATAATAAAATCTACGAAGTTAATAAAGAA
CATATTGCAAAGGTTGTTTCAAAGTGGACTCAGATACCAGTAGAAAGGCTTACAGAGAAAGAATCTAGTAGACTTCTTAA
GCTAGAAGAAAAGCTTAGTAAAAGAGTTATAGGACAATTAGAAGCAATAAGAACCATATCAAAGGCTGTAAGAAGATCAA
GGGTAGGTCTTAAAGATCCTAAAAGGCCTATTGGATCCTTTGCCTTTTTAGGACCTACTGGAGTAGGGAAAACAGAGCTT
TGTAAGGCTTTAGCAGAGGCTATGTTTGGTGATGAGAATAAATTTATTAGACTTGATATGTCTGAATATATGGAAAAGCA
TGGTGTATCTAGACTTATTGGAGCTCCTCCAGGATATGTAGGATATGAAGAGGGTGGTCAGCTTACAGAAAAGGTAAGAA
GAAATCCTTACTCAGTAATACTTTTTGATGAAATAGAGAAAGCACATCCAGATATATTTAATGTTCTTCTTCAAATATTA
GAAGATGGTGTTCTTACAGATGGAAAAGGTAAAACAGTAGATTTTAAGAATACAATAATCATAATGACTTCAAATATTGG
AGCAGATAAATTAGATAAGAAAAATGCAGTTGGATTTAGTGCTAAAGAGGATAAGGAACGAGATTATGATAAAATGAAAG
GAATTATGTTAGAAGAGCTAAAACAAAACTTCAAACCGGAATTTGTAAATAGATTAGATGACATAGTTGTATTCCATAGT
TTAGAAAAGGATCATCTTTTAAAAATTGTTGATCTTATGATATGTTCTCTAAAAGAGAGGTTAAATGATTTACAACTTTC
TTTGAATTTTTCTCAAGAGTGTAAAGAATTTTTAGTTAAAAAGGGCACTGAATTAAAATATGGAGCACGTCCATTAAGAA
GAGTTATAACTAAATATATTGAAGATAGATTAAGTGAAGAACTTTTAAGTGGAAATATATTAAGAGGATCTAAGGTTGAT
GTTTTCTTAGAAGACGACGTTGTAAAATTTAAAAAAACTGTTTGA

Protein sequence :
MRLDNFNENSKIVINKGKESSLMLKHGYMGTEHLLIGLINENGQCSKILEESNVTEEKVLSFIKLYVGIGEVNYSLDEVP
FTPRCKKILDRSVEIAKEYGHSISRPEHILLALIKEREGVANLILTKIVKNDIKNISDKLNNILGRIPSKESKSLKEKEK
PKRKDTPTLNLYGINLIERADKNKLDPVIGRKDETQRLLEILCRRMKNNPCLIGEPGVGKTAVVEGLAQRILLGEVPDII
KDKRIFTLDVTSMLAGAKYRGEFEERLKKVLNEVKDSDDIILFIDEMHNIVGAGGAEGAIDASNILKPALARGEIQCIGA
TTTDEYRKNIEKDSALERRFQPVVVKEPSKEDSVLILKGLREKYEVHHNVKLTDEAIEAAVNLSSRYITDRFLPDKAIDL
IDEAAAKVRIESMIVPPRLFKQEELIANLKVEKEEAIKLQDFELAAKLRDEELMLQEELERDKELWREENYNKIYEVNKE
HIAKVVSKWTQIPVERLTEKESSRLLKLEEKLSKRVIGQLEAIRTISKAVRRSRVGLKDPKRPIGSFAFLGPTGVGKTEL
CKALAEAMFGDENKFIRLDMSEYMEKHGVSRLIGAPPGYVGYEEGGQLTEKVRRNPYSVILFDEIEKAHPDIFNVLLQIL
EDGVLTDGKGKTVDFKNTIIIMTSNIGADKLDKKNAVGFSAKEDKERDYDKMKGIMLEELKQNFKPEFVNRLDDIVVFHS
LEKDHLLKIVDLMICSLKERLNDLQLSLNFSQECKEFLVKKGTELKYGARPLRRVITKYIEDRLSEELLSGNILRGSKVD
VFLEDDVVKFKKTV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 51
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 7e-88 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC NP_563357.1 negative regulator of genetic competence MecB/ClpC VFG0079 Protein 0.0 53
clpC NP_563357.1 negative regulator of genetic competence MecB/ClpC VFG0080 Protein 2e-148 53