Gene Information

Name : guaA (CCA00573)
Accession : NP_829437.1
Strain : Chlamydophila caviae GPIC
Genome accession: NC_003361
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 657481 - 659019 bp
Length : 1539 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGAGTAATATTCTCATTCTTGATTTTGGTTCCCAATATACGAACGTTCTAGCAAAAAAAATACGTTTGCTTTCCGTTTT
TTGTGAGGTCCTCACTTGGAATACACCTTTAGAAAAGATTCTTCAAATATCTCCCTCAGGTCTAATTTTTTCAGGAGGAC
CACATTCGGTTTATCAGGAGAATAGCCCTAAAGTTGATAAGGAAATCTATAACAGCAACATCCCTATACTTGGAGTGTGC
TATGGCATGCAGCTGATTGCTAGAGATTTTGGAAGTGAAGTTCAGGGAGGAAAAAGCGAATTTGGTTATACACCTATAGT
GTTTTATCCAAGCGAACTTTTTAAAGGTCTTGTTGATCAGGATGCTTTCCATACAGAAATTCGAATGAGTCATTGTGATT
CTGTTGTTATTCCTCCTAAAGATTTCTTTGTTATAGCGAGTTCTCAGCACTGTCCTATTGCTGCTATAGAATGCCCAGAG
AAAAAACTTTTTGGTCTTCAATTCCATCCTGAAGTTTCAGATTCTCAAGCCGTAGGGGATAAAATTTTATCAAATTTTGT
GAAGCATATTTGTCAGGCCTCAGAAACTTGGAAAATTGAAACAATAGAAAAACAACTTATTCAAAGCATTAAAGAAAAGG
TGGGAGAAACAGAACGTGTCCTTCTCGGCCTATCTGGAGGCGTAGATTCTTCTGTTTTAGCTGTTTTGCTTCATAATGCT
CTAGGTGATCGCTTGTCTTGTGTCTTCGTTGATACTGGACTATTAAGAAAGAATGAAGTGGAAGAAGTTAAACAACAATT
CTCTTCTCTAGGGTTAGAGATCCTTGTGGTAGATGCTTCTGAAAAATTTTTCCATGACCTATCCGGAATAGAAGATCCTG
AGCAAAAACGTAAAGTCATAGGAGCCGCCTTTATCGAAGTTTTCGATGAAGTATCTAGAAATCTCGATGTTCAATGGTTA
GCTCAGGGGACTATTTACTCTGATGTAATTGAATCTGCAAAATCTTGTGACGCAACACAAGTAATCAAGTCTCACCATAA
TGTAGGTGGACTTCCAGAAAAGTTGAATTTGAAGCTTTTAGAACCTCTACGTTTTCTTTTTAAAGATGAAGTTAGAGCTT
TAGGTAAAGTTTTGGGTTTGCCGGACGTCCTAATATCCCGACATCCTTTTCCTGGTCCTGGTTTAGGAGTCCGAGTTCTT
GGGGAAGTTCGTCGGGAATATGTAGAAATAGTGAAAAATGCTGACAGCATTTTTATTGAAGAACTAAAAAAAGCGAATTT
ATACCACAAGGTTAGCCAAGCTTTTGCTGTTTTCTTGCCATGTAAATCTGTTGCTGTAAAAGGTGACTGCCGTCATTACG
GTTATACGATAGCTTTACGTGCAATAGAATCTACTGATTTTATGACAGCATGCTGGCCATCTTTATCTAGAGAATTTCTT
AACCGTTGTTCCTCGCGTATCATTAATGAAATCCCTGAAGTTTGCAGGGTGGTTTACGATATTTCCGATAAACCGCCGGC
AACTATTGAGTGGGAGTAA

Protein sequence :
MSNILILDFGSQYTNVLAKKIRLLSVFCEVLTWNTPLEKILQISPSGLIFSGGPHSVYQENSPKVDKEIYNSNIPILGVC
YGMQLIARDFGSEVQGGKSEFGYTPIVFYPSELFKGLVDQDAFHTEIRMSHCDSVVIPPKDFFVIASSQHCPIAAIECPE
KKLFGLQFHPEVSDSQAVGDKILSNFVKHICQASETWKIETIEKQLIQSIKEKVGETERVLLGLSGGVDSSVLAVLLHNA
LGDRLSCVFVDTGLLRKNEVEEVKQQFSSLGLEILVVDASEKFFHDLSGIEDPEQKRKVIGAAFIEVFDEVSRNLDVQWL
AQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPDVLISRHPFPGPGLGVRVL
GEVRREYVEIVKNADSIFIEELKKANLYHKVSQAFAVFLPCKSVAVKGDCRHYGYTIALRAIESTDFMTACWPSLSREFL
NRCSSRIINEIPEVCRVVYDISDKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-107 47
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-107 47
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-107 47
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-96 43