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Name : ureC (alr3670) Accession : NP_487710.1 Strain : Nostoc sp. PCC 7120 Genome accession: NC_003272 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 4424795 - 4426501 bp Length : 1707 bp Strand : + Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGCCCTACAGAATGTCCCGCCAAGCCTACGCTGAAACCTACGGCCCCACAGTAGGCGATCGCATCCGACTTGCTGATAC AGAATTATTTATACAAGTAGAGCAAGACTTCACAACCTACGGCGATGAGGTGAAATTCGGCGGTGGTAAAGTCATTAGAG ATGGGATGGGACAATCTCCCATTGCTAACGCCGATGGTGCAGTAGATTTAGTCATTACGAATGCTTTAATCCTCGATTGG TGGGGGATTGTCAAAGCAGATATCGGCATTAAAGATGGCAAAATATTTAAAATTGGGAAAGCCGGGAATCCCTATATTCA AGATCATGTAGATATTATTATCGGCCCTGGAACCGAAGCCTTAGCGGGGGAAGGAATGATTCTCACGGCTGGCGGTATTG ATACCCATATTCATTTTATTTGTCCCCAACAAATTGAAGTAGCGATCGCCTCCGGTATCACTACTATGATTGGCGGCGGT ACAGGCCCAGCCACAGGAACCAACGCCACCACCTGCACCCCCGGCCCTTGGAATATGTACCGGATGCTGCAAGCGGCTGA TGCGTTTCCTATGAACTTAGGATTTTTAGGTAAAGGTAACGCCAGTCAACCTCAAGGCTTAGTAGAACAAATTTTTGCGG GTGCAATTGGTTTAAAGCTGCACGAAGATTGGGGAACCACACCCGCCACCATTGATACTTGCTTGACTGTAGCCGACGAA TACGACGTACAAGTGGCCATTCACACCGACACCCTCAACGAAGCCGGATTTGTCGAAGATACCATCGCCGCTTTTAAAAA TCGCGCCATCCATACTTACCACACCGAAGGCGCAGGCGGTGGACACGCACCAGATATTATCAAAGTCTGTGGACAAGCCA ACGTTCTTCCATCTTCCACCAACCCTACCCGCCCTTACACCGTCAACACCTTAGACGAACACCTCGATATGTTGATGGTA TGTCATCACCTTGATCCAGCGATCGCTGAAGATGTGGCTTTTGCTGAATCCCGCATCCGCCGCGAAACCATCGCCGCCGA AGATATTCTCCATGATTTAGGCGCGTTTAGTATGATTGCTTCCGATTCCCAAGCTATGGGCAGAGTAGGGGAAGTAATAA TTCGCACTTGGCAGACATCCCACAAAATGAAGGTGCAACGGGGAAGCCTTACCGGAGATGCTGAAGCAGACAATTTAAGA GCTAAAAGATATGTTGCTAAATACACAATCAATCCGGCAATTACGCATGGAATCGCTCAGTATGTAGGTTCTGTAGAAGC AGGTAAACTTGCAGATTTATGTTTGTGGCGACCAGCGTTTTTTGGTGTCAAACCAGAGATAGTCATTAAAGGCGGGATGA TTGCTTGGTCACAAATGGGTGATGCTAACGCCAGCATTCCCACACCGCAACCTGTGCATATGCGTCCCATGTTTGGTAGT TTTGCAGGTGCGAGAAATGCCACATCTTTAACCTTTGTTTCCCAAGCCGCTTTAGAAAGAGAAATTCCTCAGCAATTGGG TTTACGAAAATCAGCAGTCGCAGTTTCTGGAACTCGCCAATTAACTAAACAGGATATGAAACTGAATGATGCCTTACCTC ATATAGAAGTAGATTCAGAATCCTATGAAGTTAGAGCCGATGGGGAATTGTTGACTTGTGAACCTGCAACAGTGTTACCA ATGGCGCAGAGGTATTTTTTATTTTAA Protein sequence : MPYRMSRQAYAETYGPTVGDRIRLADTELFIQVEQDFTTYGDEVKFGGGKVIRDGMGQSPIANADGAVDLVITNALILDW WGIVKADIGIKDGKIFKIGKAGNPYIQDHVDIIIGPGTEALAGEGMILTAGGIDTHIHFICPQQIEVAIASGITTMIGGG TGPATGTNATTCTPGPWNMYRMLQAADAFPMNLGFLGKGNASQPQGLVEQIFAGAIGLKLHEDWGTTPATIDTCLTVADE YDVQVAIHTDTLNEAGFVEDTIAAFKNRAIHTYHTEGAGGGHAPDIIKVCGQANVLPSSTNPTRPYTVNTLDEHLDMLMV CHHLDPAIAEDVAFAESRIRRETIAAEDILHDLGAFSMIASDSQAMGRVGEVIIRTWQTSHKMKVQRGSLTGDAEADNLR AKRYVAKYTINPAITHGIAQYVGSVEAGKLADLCLWRPAFFGVKPEIVIKGGMIAWSQMGDANASIPTPQPVHMRPMFGS FAGARNATSLTFVSQAALEREIPQQLGLRKSAVAVSGTRQLTKQDMKLNDALPHIEVDSESYEVRADGELLTCEPATVLP MAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 2e-169 | 70 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 2e-169 | 70 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-160 | 65 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-159 | 65 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-160 | 65 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-160 | 65 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | NP_487710.1 | urease subunit alpha | VFG0270 | Protein | 4e-150 | 64 |
