Gene Information

Name : guaA (all2846)
Accession : NP_486886.1
Strain : Nostoc sp. PCC 7120
Genome accession: NC_003272
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3467094 - 3468716 bp
Length : 1623 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAATACAGCGGTGACTCTACTAACCGAACAAGCCCCTCAACCAATAGAAGAGTTTGGGCAGCTTGAGCGTCAAATCAT
TATCATATTAGACTTCGGCTCTCAGTATTCAGAACTGATTGCCCGACGCATCCGCGAGACTCAAGTATACTCTGAAGTTT
TGTCTTATCGCACCCCTGCTGAACATTTACGCCAACTCAATCCCAAGGGAATTATTCTTTCTGGTGGCCCCAGTTCAGTT
TATAGCGATCGCGCTCCCCATTGTGACCCAGAAATCTGGAATTTGGGAGTCCCCATTTTGGGTGTCTGCTACGGAATGCA
GCTGATGGTCAACCAACTCGGTGGCGAAGTAGCCAAAGCTGACCGGGGTGAGTATGGGAAAGCATCATTACACATTGATG
ATCCCACCGATTTACTGACCAACGTTGAAGATGGCACAACAATGTGGATGAGTCATGGTGATTCAGTCACAAAAATGCCC
CCAGGGTTTGAAGTGTTGGCACATACAGATAATACTCCCTGTGCTGCTGTTGCTGACCACGAGAAAAAGCTTTATGGCGT
GCAGTTCCATCCAGAAGTAGTCCATTCCGTTGGTGGTTTGGCATTAATTCGCAACTTTGTTTATCACATTTGTGAGTGTG
AACCCACCTGGACGACGGCTGCTTTTGTGGAAGAAGCTATTCGGGAAGTCCGGGCTAAAGTTGGTGACAAGCGAGTACTA
TTGGCGCTTTCGGGAGGAGTCGATTCTTCTACCCTGGCTTTCTTGATGCACAAAGCCATCGGCGACCAATTGACTTGTGT
ATTTATCGACCAAGGCTTTATGCGGAAGTATGAGCCAGAAAGGTTGGTGAAACTATTTCAGGAGCAGTTTCATATCCCTG
TTGAATATGTTAACGCCCGCGATCGCTTCTTAGATATCATGTCAGGTGTGACAGACCCAGAAGAAAAACGTCGTCGCATT
GGACATGAATTCATCCAGGTATTTGAAGAAACATCTAAAAATCTGGGCCCCTTTGACTATCTAGCACAAGGGACTCTTTA
CCCAGATGTCATTGAATCGGCTGATACCAATGTTGACCCCCAAACTGGGGAACGGGTAGCGGTAAAAATCAAAAGCCATC
ACAACGTTGGCGGCTTACCCAAAGACTTGAGATTTAAACTAGTTGAACCCCTGCGGAAACTGTTTAAAGATGAAGTCCGT
AAAGTAGGGCGGTCTGTTGGTTTACCAGAAGAGATTGTTCAACGCCAGCCATTTCCTGGCCCTGGTTTAGCTATTCGGAT
TTTGGGTGAAGTCACCGCCGACAGATTGAACATTCTCCGCGATGCTGATTTGATTGTGCGCCAAGAAATTAACCAACGCG
GTTTATACAATGAATATTGGCAAGCATTCGCAGTTTTACTACCTATCCGCAGTGTGGGCGTAATGGGTGATCAACGCACC
TATGCTTATCCTATCGTCTTACGCATTGTCAAGAGCGAAGATGGCATGACAGCAGATTGGGCGCGTGTACCTTACGATGT
TTTAGAAGCAATTTCTAACCGCATTGTCAACGAAGTTAAAGGCGTTAACCGCGTGGTGTTTGATATTACTTCCAAGCCAC
CCGGAACCATTGAGTGGGAATAA

Protein sequence :
MNTAVTLLTEQAPQPIEEFGQLERQIIIILDFGSQYSELIARRIRETQVYSEVLSYRTPAEHLRQLNPKGIILSGGPSSV
YSDRAPHCDPEIWNLGVPILGVCYGMQLMVNQLGGEVAKADRGEYGKASLHIDDPTDLLTNVEDGTTMWMSHGDSVTKMP
PGFEVLAHTDNTPCAAVADHEKKLYGVQFHPEVVHSVGGLALIRNFVYHICECEPTWTTAAFVEEAIREVRAKVGDKRVL
LALSGGVDSSTLAFLMHKAIGDQLTCVFIDQGFMRKYEPERLVKLFQEQFHIPVEYVNARDRFLDIMSGVTDPEEKRRRI
GHEFIQVFEETSKNLGPFDYLAQGTLYPDVIESADTNVDPQTGERVAVKIKSHHNVGGLPKDLRFKLVEPLRKLFKDEVR
KVGRSVGLPEEIVQRQPFPGPGLAIRILGEVTADRLNILRDADLIVRQEINQRGLYNEYWQAFAVLLPIRSVGVMGDQRT
YAYPIVLRIVKSEDGMTADWARVPYDVLEAISNRIVNEVKGVNRVVFDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-139 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-140 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-140 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-130 53