Gene Information

Name : thyA (BF3523)
Accession : YP_213125.1
Strain : Bacteroides fragilis NCTC 9343
Genome accession: NC_003228
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 4149174 - 4149968 bp
Length : 795 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAATATTTAGACCTGCTCGACCGAGTGTTGACGGAGGGAATAGAAAAAGGTGACCGTACCGGAACGGGAACCAT
CAGTGTCTTCGGACACCAGATGCGTTTCAACCTGGACGAGGGATTCCCTTGCCTGACTACCAAGAAACTTCATCTGAAAT
CAATCATTTACGAACTACTGTGGTTCCTCAAAGGAGACACGAATGTGAAATATTTGCAGGACCACGGCGTACGCATCTGG
AACGAATGGGCGGACGAAACAGGCGATCTGGGACATATATATGGATACCAGTGGCGTTCGTGGCCAACCTACGACGGAGG
ATTTATCGACCAGATCAGCGAAGCTGTAGATGCCATCAAGCACAATCCCGATTCACGCCGCATCATTGTCAGTGCATGGA
ATGTAGGAGACCTGGATCACATGAACCTCCCTCCTTGCCACGCATTCTTCCAGTTTTACGTAGCAAACGGACGGCTGAGC
CTGCAACTCTATCAACGCAGCGCCGATATCTTCCTGGGGGTACCTTTCAATATAGCATCTTATGCATTGCTGCTGCAGAT
GATGGCGCAAGTCACCGGTCTGCAGGCAGGAGACTTTATCCACACACTGGGCGACGCACATATCTACCTGAACCACCTGG
AACAGGTGAAACTCCAGCTCAGCCGGGAACCGCGCCCACTACCACAAATGAAGATCAATCCGGACGTGAAAAACATCTTC
GACTTCCAATTCGAGGACTTTGAATTAGTAAATTATGATCCGCACCCGCACATCGCTGGAAAAGTTGCGGTATAA

Protein sequence :
MKQYLDLLDRVLTEGIEKGDRTGTGTISVFGHQMRFNLDEGFPCLTTKKLHLKSIIYELLWFLKGDTNVKYLQDHGVRIW
NEWADETGDLGHIYGYQWRSWPTYDGGFIDQISEAVDAIKHNPDSRRIIVSAWNVGDLDHMNLPPCHAFFQFYVANGRLS
LQLYQRSADIFLGVPFNIASYALLLQMMAQVTGLQAGDFIHTLGDAHIYLNHLEQVKLQLSREPRPLPQMKINPDVKNIF
DFQFEDFELVNYDPHPHIAGKVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-82 66