Gene Information

Name : thyA (lmo1874)
Accession : NP_465399.1
Strain : Listeria monocytogenes EGD-e
Genome accession: NC_003210
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 1947914 - 1948858 bp
Length : 945 bp
Strand : -
Note : similar to thymidylate synthase; ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-deriv

DNA sequence :
ATGAAACAATATTTGGATTTAGAAAAGTACGTTTTAGAGAATGGAACACAAAAAGGAGATCGCACTGGGACTGGAACAAT
CAGCACATTTGGTTATCAAATGCGTTTTGATTTGCAGGAAGGCTTTCCAATTATGACAACAAAACGGGTACCATTTAAAC
TTGTAGTAAGTGAACTGCTATGGTTTTTACATGGAGATACGAATATTCGCTACCTTTTACAGCATAATAATAACATTTGG
AATGAATGGGCTTTTGAGCGTTTTGTGAAAAGCGATGATTACAAGGGCGAAGATATGACAGACTTTGGACTAAGAGCGGA
ACGTGATCCGGCTTTCAAAGAAGTATATCAAGCTGAGATGGAGAAGTTTAAAACACGTATTATAGAAGATGAAGCGTTCG
CGACTAAATACGGTGAGCTAGGTAATATTTACGGTAAACAATGGCGCGAATGGAAAACTTCGCAAGGGGAAACAATTGAT
CAGTTAGCTGACTTGATTGAAATGATTAAAACAAACCCGAACTCACGTCGTTTGATTGTGTCTGCTTGGAATCCAGAAGA
TATTCCGAATATGGCTTTACCGCCATGTCATTCGCTATTCCAATTTTATGTAGCGGACGGAAAATTATCATGTCAGCTGT
ATCAACGTAGTGCCGATATTTTCCTAGGTGTACCATTTAATATTGCGAGTTATGCACTTCTCACACATCTGATTGCACGT
GAAGTAGGACTGGATGTTGGCGAGTTTATCCATACTATGGGAGACGCGCATCTTTATAACAATCATATTGAACAAGTGAA
AGAACAGTTATCTAGAACACCGCACGCGCTTCCAAAATTAGTACTTTCAGATAAACCAGCAACGATTTTTGATTTTGAAG
TAGCAGATATTTCACTTGATGGCTATAATCCAGATCCATCGATTAAAGCACCAATTTCAGTATAA

Protein sequence :
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIW
NEWAFERFVKSDDYKGEDMTDFGLRAERDPAFKEVYQAEMEKFKTRIIEDEAFATKYGELGNIYGKQWREWKTSQGETID
QLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAR
EVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVADISLDGYNPDPSIKAPISV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 3e-101 64