Gene Information

Name : guaA (lmo1096)
Accession : NP_464621.1
Strain : Listeria monocytogenes EGD-e
Genome accession: NC_003210
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1129945 - 1131501 bp
Length : 1557 bp
Strand : +
Note : highly similar to GMP synthetase; contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGTTTAAAATTATGAAAGACTTTACCGAGCAAGAGAAAATTATCGTTCTAGATTTTGGTAGTCAGTACAATCAACTAAT
TACGCGCCGCATTCGTGAATTCGGTGTGTACAGTGAATTACATCCGCATACTATTACAGTTGAAGAAATGAAAGCACTAA
ATCCAACGGGGATTATTTTTTCAGGAGGACCTAACAGTGTGTATGACGAAGATGCCTTCCGCGCTGACGAAAGAATCTTT
GACATGGGAATTCCGATTTTGGGAATTTGTTACGGCATGCAATTAATGACAACGCACTTCGGTGGCAAAGTAGAACGTGC
GAAAGACCGCGAATACGGGAAAGCGGACATTCACGTTGAGAAGCCAAACCGTTTATTTGCTGGACTACCAACCGATCAAG
TTGTTTGGATGAGTCACGGCGATTTAGTCGTTGAGGAGCCTGCTGGTTTTGAAGTAACAGTTACTAGTAAATCTTGCCCA
ATTGCAGGTATTGCGGACGAAGAACGTTCACTTTACGGCGTGCAATTCCACCCAGAAGTACGTCACTCCGTTTATGGCAA
CGAATTACTGAAGAATTTTGCATTAAATGTTTGTGGCTGTAAAGGCGACTGGACAATGGAAAACTTTAGTGAAGTAGAAA
TCGCAAAAATCCAAGAAATCGTAGGCGACAAAAAAGTCTTGCTTGCCCTTTCTGGCGGTGTAGATTCCTCTGTTGTTGGC
GTGTTAATTCATAAAGCAATAGGCGACCAACTAACATGTATTTTCGTTGACCACGGCCTTCTTCGTAAAGGGGAAGCTGA
CCAAGTAATGGAGACATTACAAGGCGAATTCAACATGAACATCATCAAAGTAGATGCGAAAAAACGCTTCATGGACAAAC
TTGCTGGCGTTTCTGACCCAGAACAAAAACGTAAAATCATCGGCAACGAATTCATTTACGTATTTGACGATGAAGCCAAC
AAATTAGATGGCGTAGAATTCCTTGCACAAGGAACACTCTACACAGACATCATCGAAAGTGGTACAGCAACTGCCCAAAC
AATCAAGTCTCACCACAACGTAGGCGGCTTACCAGAAGATATGCAATTTAAACTAATCGAACCATTAAATACACTTTTCA
AAGATGAAGTTCGCGCACTAGGAACCGAACTTGGCATGCCTGACGCAATCGTTTGGCGCCAACCATTCCCAGGCCCAGGC
TTAGGAATCCGTGTGCTTGGCGAAATTACGGAAGAGAAATTAGAGATTGTTCGTGATTCTGATTACATCTTGCGTGAAGA
AATCAAAAACGCAGGTCTAGAACGCGAAATCTGGCAATACTTTACTGCTCTTCCAAATATCCGTAGCGTTGGTGTTATGG
GTGATGGTAGAACGTATGACCATACTGTGGTTGTTCGTGCAGTGACGAGTATTGATGGTATGACAGCCGATTGGGCACGT
ATTCCGTGGGATGTACTGGAGAAAATTTCGGTACGGATTGTGAATGAAGTGGATCATGTGAATCGTGTTGTTTATGATAT
TACGAGTAAGCCACCAGCTACGGTTGAGTGGGAATAG

Protein sequence :
MFKIMKDFTEQEKIIVLDFGSQYNQLITRRIREFGVYSELHPHTITVEEMKALNPTGIIFSGGPNSVYDEDAFRADERIF
DMGIPILGICYGMQLMTTHFGGKVERAKDREYGKADIHVEKPNRLFAGLPTDQVVWMSHGDLVVEEPAGFEVTVTSKSCP
IAGIADEERSLYGVQFHPEVRHSVYGNELLKNFALNVCGCKGDWTMENFSEVEIAKIQEIVGDKKVLLALSGGVDSSVVG
VLIHKAIGDQLTCIFVDHGLLRKGEADQVMETLQGEFNMNIIKVDAKKRFMDKLAGVSDPEQKRKIIGNEFIYVFDDEAN
KLDGVEFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFKLIEPLNTLFKDEVRALGTELGMPDAIVWRQPFPGPG
LGIRVLGEITEEKLEIVRDSDYILREEIKNAGLEREIWQYFTALPNIRSVGVMGDGRTYDHTVVVRAVTSIDGMTADWAR
IPWDVLEKISVRIVNEVDHVNRVVYDITSKPPATVEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 0.0 76
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 0.0 76
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 0.0 75
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-129 53