Gene Information

Name : STY0640
Accession : NP_455172.1
Strain : Salmonella enterica CT18
Genome accession: NC_003198
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 641555 - 643168 bp
Length : 1614 bp
Strand : +
Note : Fasta hit to YDID_ECOLI (548 aa), 31% identity in 550 aa overlap; Orthologue of E. coli entE (ENTE_ECOLI); Fasta hit to ENTE_ECOLI (536 aa), 86% identity in 534 aa overlap

DNA sequence : 
ATGATGCGTATACCTTTCACCCGTTGGCCGGATGAATTTGCCCGCCGTTATCGTGAAAAAGGCTACTGGCAAGACGTGCC
GTTGACCGATATTCTGACCCGCCACGCTGACAGCGATAAGACGGCGGTCATTGAAGGCGAGCGCGCATTCAGCTATCGCC
AGCTAAACCAGGCCGCGGATAATCTGGCCTGCAGTTTACGCCGTCAGGGCATCAAACCTGGCGAAACCGCTCTGGTACAA
CTGGGGAATGTACCGGAACTGTATATCACCTTTTTCGCCCTGTTGAAGCTTGGCGTAGCGCCCGTTCTGGCGCTGTTTAG
CCATCAACGTACCGAACTTAACGCCTATGCGATGCAGATCGCGCCGACGCTGGTGATTGCCGATCGCCAACATACGCTGT
TCGCCGGGGAGGACTTTCTCAACAGGTTTGTGGCTGAACACCGCTCTGCGCGGGTGGTGTTATTGCGCAACGACGACGGC
GATCACAGCCTGGACGCGGCGATGCGGCAGGCGGCGGAAGGTTTCACCGCCACGCCATCACCTGCTGACGAAGTGGCCTA
CTTTCAGCTTTCCGGCGGTACTACCGGCACGCCAAAGCTTATTCCCCGTACCCATAACGACTATTACTACAGCGTGCGCC
GCAGCAATGAGATTTGCGGTTTCAACGAGGAGACGCGTTTTCTGTGCGCGATTCCCGCCGCGCATAACTACGCCATGAGT
TCGCCGGGCGCGCTGGGCGTTTTTCTCGCCAAAGGAACGGTAGTGCTGGCGACCGATCCTGGCGCCACGCTCTGTTTCCC
GCTGATCGAAAAACACCAGATTAATGCCACGGCGCTGGTGCCGCCCGCGGTCAGTCTATGGCTACAGGCTATCCAGGAGT
GGGGCGGCAATGCGCCGCTGGCGTCATTAAGGTTATTGCAGGTTGGCGGCGCGCGGCTTTCTGCGACGCTGGCCGCCCGT
ATTCCGGCTGAAATTGGCTGTCAGTTGCAGCAGGTCTTCGGCATGGCGGAAGGGTTAGTGAACTATACCCGGCTGGACGA
TAGCCCGGAACGGATTATCAATACCCAGGGAAGACCCATGTGTCCGGACGACGAAGTGTGGGTGGCGGATGCCGACGGGA
ATCCACTGCCGCCGGGCGAGATTGGTCGTCTGATGACGCGCGGCCCCTATACTTTTCGCGGCTATTTCAACAGTCCGCAA
CACAATGTCAGCGCCTTTGACGCCAACGGTTTTTACTGTTCCGGCGATCTGATCTCCATTGATCAAGACGGCTACATCAC
CGTTCACGGGCGTGAAAAAGATCAGATCAACCGGGGCGGCGAGAAGATAGCCGCCGAAGAGATAGAAAACCTGTTACTGC
GCCACCCGGCGGTGATCCATGCGGCGCTGGTCAGCATGGAAGATGAACTGCTGGGGGAAAAAAGTTGCGCATATCTGGTG
GTAAAAGAGCCGCTGCGAGCGGTACAGGTACGCCGTTTCCTGCGAGAGCAGGGCGTGGCGGAATTTAAATTACCGGATCG
CGTGGAGTGCGTTGCGTCACTGCCGCTGACGCCGGTTGGTAAAGTCGATAAAAAACAATTACGCCAGCGGTTGGCGTCAC
GTTCACCGCTCTGA

Protein sequence : 
MMRIPFTRWPDEFARRYREKGYWQDVPLTDILTRHADSDKTAVIEGERAFSYRQLNQAADNLACSLRRQGIKPGETALVQ
LGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQHTLFAGEDFLNRFVAEHRSARVVLLRNDDG
DHSLDAAMRQAAEGFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEETRFLCAIPAAHNYAMS
SPGALGVFLAKGTVVLATDPGATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAPLASLRLLQVGGARLSATLAAR
IPAEIGCQLQQVFGMAEGLVNYTRLDDSPERIINTQGRPMCPDDEVWVADADGNPLPPGEIGRLMTRGPYTFRGYFNSPQ
HNVSAFDANGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEDELLGEKSCAYLV
VKEPLRAVQVRRFLREQGVAEFKLPDRVECVASLPLTPVGKVDKKQLRQRLASRSPL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE CAA21394.1 - Virulence HPI Protein 1e-88 41
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 1e-88 41
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-88 41
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 8e-89 41
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 2e-88 41
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-88 41
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 1e-88 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
STY0640 NP_455172.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 0.0 86
STY0640 NP_455172.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 1e-115 46
STY0640 NP_455172.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 2e-89 42