Gene Information

Name : tviB
Accession : NP_458740.1
Strain : Salmonella enterica CT18
Genome accession: NC_003198
Putative virulence/resistance : Virulence
Product : Vi polysaccharide biosynthesis protein, UDP-glucose/GDP-mannose dehydrogenase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0677
EC number : 1.1.1.-
Position : 4522618 - 4523895 bp
Length : 1278 bp
Strand : -
Note : Similar to Salmonella typhi Vi polysaccharide biosynthesis protein VipA or TviB SW:VIPA_SALTI (Q04972) (425 aa) fasta scores: E(): 0, 99.8% id in 425 aa, and to Pseudomonas aeruginosa WbpO TR:Q9RHD7 (EMBL:AF035937) (422 aa) fasta scores: E(): 0, 66.8% id

DNA sequence : 
GTGTTCGGTATAGACGAGGTAAAAATCGCGATTATTGGGCTGGGATATGTTGGGCTTCCTCTGGCAGTTGAATTTGGCAA
ATCTCGTCAGGTTGTTGGCTTCGACGTTAATAAAAAGCGTATTCTTGAATTAAAGAATGGGGTGGATGTCAATCTGGAAA
CCACTGAAGAAGAATTACGTGAGGCTCGTTATCTGAAATTTACTTCCGAGATTGAGAAGATCAAAGAATGTAATTTTTAC
ATCATCACCGTCCCGACGCCGATAAATACCTACAAGCAACCAGACCTCACCCCACTAATCAAGGCGAGTGAAACCGTTGG
TACAGTGCTGAATCGGGGAGATATTGTGGTATATGAATCTACGGTATATCCGGGATGTACCGAAGAAGAATGCGTGCCGA
TCCTTGCTCGTATGTCCGGAATGACTTTCAACCAGGATTTCTATGTCGGTTATAGCCCGGAAAGGATCAATCCCGGTGAT
AAAAAGCACCGTTTAACCAACATCAAGAAAATCACCTCCGGTTCAACCGCACAGATCGCCGAACTTATCGATGAAGTATA
TCAGCAGATCATCAGCGCAGGTACATATAAAGCAGAGAGCATCAAAGTTGCTGAGGCAGCGAAGGTGATTGAAAATACGC
AACGCGATCTGAATATTGCCTTGGTCAATGAGCTGGCGATTATTTTTAATCGTTTAAATATCGATACTGAAGCCGTGCTA
CGTGCCGCTGGCAGCAAATGGAATTTCCTGCCATTCCGTCCGGGACTGGTCGGTGGTCACTGTATTGGCGTAGATCCCTA
TTATCTGACACATAAATCTCAGGGCATTGGCTATTATCCAGAAATCATACTTGCAGGACGCCGCCTGAACGACAACATGG
GCAACTATGTCTCCGAGCAGTTGATCAAAGCAATGATCAAAAAAGGAATTAACGTTGAGGGTTCCAGCGTGCTGATTCTC
GGCTTTACCTTTAAAGAAAACTGTCCGGACATCAGAAATACACGCATTATTGATGTGGTAAAGGAACTCGGTAAATATAG
TTGTAAAGTGGATATTTTTGATCCATGGGTGGATGCCGAAGAGGTAAGACGAGAGTATGGCATTATCCCGGTATCGGAAG
TCAAATCAAGCCACTACGATGCGATCATTGTTGCAGTAGGACATCAGCAATTTAAACAGATGGGAAGTGAGGATATTCGC
GGCTTCGGAAAAGATAAACATGTACTTTATGATTTGAAGTATGTTCTTCCGGCTGAGCAGTCAGATGTGAGATTGTAA

Protein sequence : 
MFGIDEVKIAIIGLGYVGLPLAVEFGKSRQVVGFDVNKKRILELKNGVDVNLETTEEELREARYLKFTSEIEKIKECNFY
IITVPTPINTYKQPDLTPLIKASETVGTVLNRGDIVVYESTVYPGCTEEECVPILARMSGMTFNQDFYVGYSPERINPGD
KKHRLTNIKKITSGSTAQIAELIDEVYQQIISAGTYKAESIKVAEAAKVIENTQRDLNIALVNELAIIFNRLNIDTEAVL
RAAGSKWNFLPFRPGLVGGHCIGVDPYYLTHKSQGIGYYPEIILAGRRLNDNMGNYVSEQLIKAMIKKGINVEGSSVLIL
GFTFKENCPDIRNTRIIDVVKELGKYSCKVDIFDPWVDAEEVRREYGIIPVSEVKSSHYDAIIVAVGHQQFKQMGSEDIR
GFGKDKHVLYDLKYVLPAEQSDVRL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tviB NP_458740.1 Vi polysaccharide biosynthesis protein, UDP-glucose/GDP-mannose dehydrogenase Virulence SPI-7 Protein 0.0 100
tviB NP_807945.1 VI polysaccharide biosynthesis UDP-glucose/GDP-mannose dehydrogenase Virulence SPI-7 Protein 0.0 100
cap1L AAA64651.1 type 1 capsule synthesis gene Virulence SCCcap1 Protein 6e-105 52

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tviB NP_458740.1 Vi polysaccharide biosynthesis protein, UDP-glucose/GDP-mannose dehydrogenase VFG0431 Protein 0.0 100