Gene Information

Name : sirA
Accession : NP_456510.1
Strain : Salmonella enterica CT18
Genome accession: NC_003198
Putative virulence/resistance : Virulence
Product : invasion response-regulator
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG2197
EC number : -
Position : 2002473 - 2003129 bp
Length : 657 bp
Strand : -
Note : Similar to many response regulators e.g. Salmonella typhimurium quorum-sensor response-regulator controlling virulence functions SirA sirA TR:P96058 (EMBL:U67869) (218 aa) fasta scores: E(): 0, 99.5% id in 218 aa and Pseudomonas aeruginosa response regula

DNA sequence : 
TTGATCAACGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTTGAAGATATAAAGGGCAT
TAAAGTTGTCGGTGAAGCGTGCTGCGGAGAGGATGCGGTAAAATGGTGCCGTACTAACGCCGTTGACGTCGTGCTGATGG
ATATGAACATGCCCGGTATTGGCGGCCTTGAGGCGACGCGTAAAATTGCCCGATCGACAGCGGATATCAAAGTGATCATG
CTGACCGTCCATACGGAGAACCCGTTGCCCGCCAAAGTGATGCAGGCTGGCGCAGCTGGCTATCTCAGCAAAGGCGCTGC
GCCTCAGGAGGTGGTGAGCGCTATTCGTTCGGTGTATTCCGGACAACGTTATATCGCCTCCGATATCGCTCAACAGATGG
CGCTCAGTCAGATTGAGCCTGCAAAAACGGAAACGCCGTTCGCCAGTTTGTCTGAACGCGAGTTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATTTCAGAACAGCTGAATCTCAGTCCTAAAACGGTGAACAGCTATCGCTATCG
TATGTTCAGTAAATTAAACATTCATGGTGATGTTGAGCTGACTCACCTGGCAATCCGCCATGGCCTGTGTAATGCGGAGA
CGTTAACAAGCCAGTGA

Protein sequence : 
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKIARSTADIKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPAKTETPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLTSQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB0868_00306 YP_008211632.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Not tested AbaR26 Protein 2e-46 49
BJAB07104_00302 YP_008207767.1 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Not tested AbaR25 Protein 2e-46 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
sirA NP_456510.1 invasion response-regulator VFG1889 Protein 1e-54 51