Gene Information

Name : ureC (SAV_7106)
Accession : NP_828282.1
Strain : Streptomyces avermitilis MA-4680
Genome accession: NC_003155
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 8465156 - 8466877 bp
Length : 1722 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGCCTGAGATCTCGCGTCCCGCCTACGCCGACCTGTTCGGCCCGACCACCGGCGACCGCATCCGGCTCGCCGACACCGA
TCTGCTGATCGAGATCGAGGAGGATCGTTCCGGCGGTCCCGGACTCGCCGGTGACGAGGCCGTCTTCGGCGGCGGCAAGG
TCATCCGCGAATCCATGGGCCAGGCGCGCGCCACGCGTGCGGACGGCACCCCGGACACGGTCATCACCGGTGTCGTCATC
GTCGACCACTGGGGCATCGTCAAGGCCGACGTCGGCATGCGCGACGGCCGGATCACCGGCATCGGCAAAGCGGGCAACCC
GGACACCATGGACGGTGTGCACCCCGACCTGGTCATCGGTCCGGAGACCGAGATCATCGCGGGCAACGGCCGGATCCTCA
CCGCGGGCGCCATCGACGCGCATGTGCACCTGATCTGCCCGCAGATCGCCGACGAGGCGCTCGGCTCCGGGATCACCACC
CTCGTCGGCGGTGGCACCGGCCCCGCCGAGGGCTCCAAGGCCACCACCGTCACACCCGGCCCCTGGCACCTGGCGCGGAT
GCTGGAGGCGATGGAGGAGTACCCGCTCAACTTCGGGCTCCTCGGCAAGGGCAACACCGTCTCGCACGACGCGATGCTGT
CGCAGATCCGCGGCGGAGCACTCGGTCTCAAGCTGCACGAGGACTGGGGATCCACGCCGGCCGTCATCGACGCCGCGCTG
ACCGTCGCCGACCGGACCGGCGTCCAGATCGCCATCCACACGGACACGCTGAACGAGGCCGGCTTCGTGGGCGACACGCT
CGCCGCGATCGGCGGCCGCGGCATCCACGCCTACCACACCGAGGGTGCGGGCGGCGGGCACGCGCCGGACATCATGAGCG
TGGTCTCCGAGCCGCACGTGCTGCCCAGCTCCACCAACCCGACCCGGCCGTTCACCGTCAACACCGCCGAGGAACACCTC
GACATGCTGATGGTCTGCCACCACCTCAACCCGGCGGTCCCCGAGGACCTCGCCTTCGCCGAGTCCCGCATCCGGCCGTC
GACGATCGGGGCGGAGGACATCCTGCACGACCTGGGCGCCATCTCGATCATCTCGTCCGACGCCCAGGCCATGGGACGCG
TGGGCGAGGTCATCATGCGGACGTGGCAGACGGCCCATGTCATGAAGCGGCGGCGCGGCGCGCTCCCCGGTGACGGCCGC
GCGGACAACCACCGCGTACGTCGCTATGTCGCCAAGTACACGATCAACCCGGCACTCGCGCAGGGCCTCGCCCGCGAGAT
CGGCTCCGTCGAGACGGGCAAACTCGCCGACCTGGTGCTGTGGGAGCCCGCGTTCTTCGGGGTCAAGCCGCACCTCGTCA
TCAAGGGCGGACAGATCGCGTACGCGCAGATGGGCGATGCCAACGCGTCCATCCCCACGCCGCAGCCGATTCTGCCCCGG
CCGATGTTCGGGGCGATCGGGCGCGCGCCGGCCTCGAACTCGTTCAACTTCGTGGCGCCGCTCGCCATCGAGGACGGGCT
GCCGGAGCGGCTCTCGCTCGGGAAGCGGTTCGTGGCGATCGAGTCGACGCGCGGTGTGACCAAGGCGGACATGCGGGAGA
ACGACGCACGGCCGCGGGTACGGATCGACCCCGACAGCTTCGCCGTGCACATCGACGGGGAGCTGGTCGAGGCCACTCCG
GCCGCCGAACTGCCCATGGCCCAGCGCTACTTCCTCTTCTGA

Protein sequence :
MPEISRPAYADLFGPTTGDRIRLADTDLLIEIEEDRSGGPGLAGDEAVFGGGKVIRESMGQARATRADGTPDTVITGVVI
VDHWGIVKADVGMRDGRITGIGKAGNPDTMDGVHPDLVIGPETEIIAGNGRILTAGAIDAHVHLICPQIADEALGSGITT
LVGGGTGPAEGSKATTVTPGPWHLARMLEAMEEYPLNFGLLGKGNTVSHDAMLSQIRGGALGLKLHEDWGSTPAVIDAAL
TVADRTGVQIAIHTDTLNEAGFVGDTLAAIGGRGIHAYHTEGAGGGHAPDIMSVVSEPHVLPSSTNPTRPFTVNTAEEHL
DMLMVCHHLNPAVPEDLAFAESRIRPSTIGAEDILHDLGAISIISSDAQAMGRVGEVIMRTWQTAHVMKRRRGALPGDGR
ADNHRVRRYVAKYTINPALAQGLAREIGSVETGKLADLVLWEPAFFGVKPHLVIKGGQIAYAQMGDANASIPTPQPILPR
PMFGAIGRAPASNSFNFVAPLAIEDGLPERLSLGKRFVAIESTRGVTKADMRENDARPRVRIDPDSFAVHIDGELVEATP
AAELPMAQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 6e-175 61
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 6e-175 61
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 4e-158 58
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-158 58
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 1e-158 58
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 1e-158 58

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC NP_828282.1 urease subunit alpha VFG0270 Protein 2e-150 55