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Name : leuS (SAV_5488) Accession : NP_826665.1 Strain : Streptomyces avermitilis MA-4680 Genome accession: NC_003155 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 6661895 - 6664783 bp Length : 2889 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGAGCGAGACGAACCCCGCTGCCGCCTCCGAGGTGGCCGCGCCGCACCGCTACACGGCCGCCGTGGCCGCGGAGATCGA GGCACGCTGGCAGGACTTCTGGGACGCCGAGGGTACGTACGAGGCGCCCAACCCGACCGGTGACCTGGCCGGGGGTCCCG CGCTGGTCGCCAAGCCCAAGAAGTTCGTCATGGACATGTTCCCGTACCCCTCCGGTGCGGGACTGCACGTCGGTCACCCC CTGGGCTACATCGCCACCGATGTATTCGCCCGGTTCCAGCGCATGACCGGCCACAACGTCCTGCACACCCTGGGCTTCGA CGCCTTCGGCCTGCCCGCCGAGCAGTACGCCGTGCAGACGGGCACGCACCCGCGCGTGTCCACCGAGGCCAACATCGAGA ACATGAAGGTCCAGCTGCGCCGGCTGGGCCTGGGCCACGACAAGCGCCGGTCGTTCGCCACGATCGACCCGGACTACTAC AAGTGGACCCAGTGGATCTTCCTGCAGATCTTCAACTCCTGGTACGACGAGGAGGCGAACAAGGCCCGCCCGATCGCCGA ACTGGTCGCCCAGTTCGAGTCCGGCGAGCGCGCCGTCCCGCGCGCTGACGGTGCCACGCGCGCGTGGCGGGAGCTGACCG CCGCCGAGCGCGCCGACGTCCTGGGCGAGTACCGCCTGGCGTACGCCTCCGAGGCGCCGGTCAACTGGAGCCCCGGACTG GGCACCGTACTGGCCAACGAGGAGGTCACCGCCGACGGCCGTTCCGAGCGCGGCAACTTCCCCGTCTTCAAGGCCAAGCT GCGCCAGTGGAACATGCGCATCACCGCCTACGCCGACCGGCTGCTGGACGACCTGGACGCGCTGGACTGGCCCGAGGCCA TCAAGCTGCAGCAGCGCAACTGGATCGGCCGCTCCGAGGGTGCCCGCGTCGACTTCCCGATCGACGGCGAAGCCGTCACG GTCTTCACCACCCGCCCGGACACCCTGTTCGGCGCCACCTACATGGTGCTGGCGCCCGAGCACCCGCTGGTCGAGAAGTT CACCCCGGCCGCCTGGCCCGAGGGCACCCACGACGTGTGGACCGGCGGCCACGCCACGCCGGCCGAGGCCGTTGCCGCCT ACCGTGCCCAGGCCGCCTCGAAGTCCGACGTCGAGCGCCAGGCCGAGGCCAAGGACAAGACCGGCGTCTTCACGGGCGCG TACGCGACCAACCCGGTCAGCGGCGAGCAGGTCCCGGTCTTCATCGCCGACTACGTACTGATGGGCTACGGCACCGGCGC GATCATGGCCGTCCCGGCGCACGACACGCGTGACTTCGCGTTCGCGCGCGCCTTCGAGCTGTCGATGCGCTGTGTCGTCG AGCCTTCCGACGACCGCGGAACGGACCCCAGCACGTGGGACGACGCGTTCGCCTCGTACGACGCGAAGATCGTCAACTCG TCGAGCGGTGAGATCTCCCTGGACGGCCTGGGTGTCGTCGAGGCCAAGGCACGCATCACCGAGTGGCTGGAGCGCAAGGG CCTCGGCGAGGGCACCGTCAACTTCCGGCTGCGCGACTGGCTGTTCAGCCGCCAGCGCTACTGGGGCGAGCCCTTCCCGA TCGTCTACGACGAGGACGGCATCGCCCACGCCCTGCCCGAGTCGATGCTGCCCCTGGAGCTGCCGGAGGTCGAGGACTAC TCGCCGCGCACTTTCGACCCGGACGACGCCAACACGTCTCCGGAGACCCCGCTGTCCCGCAACGAGGACTGGGTCAACGT CACCCTGGACCTGGGTGACGGCCGTGGTCCCCAGAAGTACCGTCGCGAGACCAACACCATGCCCAACTGGGCGGGCTCCT GCTGGTACGAGCTGCGCTACCTGGATCCGCACAACGACCAGAAGCTGGTCGACCCCGCCATCGAGCAGTACTGGATGGGC CCGCGCGAGGGGCAGCCGACCGGTGGCGTCGACCTGTATGTCGGCGGCGCCGAGCACGCCGTGCTGCACCTGCTGTACGC GCGCTTCTGGTCGAAGGTCCTGTTCGACCTGGGGCACATCTCGTCGGCCGAGCCGTTCCACAAGCTGTTCAACCAGGGCA TGATCCAGGCCTACGTCTACCGCGACAGCCGTGGCATCGCGGTGCCGGCCGCCGAGGTGGAGGAGCGCGACGGCGCGTAC TACTACCAGGGCGAGAAGGTCTCCCGACTGCTGGGCAAGATGGGCAAGTCCCTGAAGAACGCGGTCACTCCGGACGAGAT CTGCGCCGAGTACGGGGCGGACACCCTGCGCCTGTACGAGATGGCGATGGGTCCCCTGGACGTGTCGCGGCCGTGGGACA CGCGCGCGGTGGTGGGCCAGTTCCGGCTGCTGCAGCGGCTGTGGCGCAACGTCGTCGACGAGGCCACCGGCGAGGTCACG GTCGTCGACGCCGAGCCGGACGAGGAGACGCTGCGTGCTCTGCACAAGGCGATCGACGGCGTCCGCCAGGACCTGGAGGG CATGCGGTTCAACACCGCCATCGCCAAGGTCACCGAGCTGAACAACCAGCTGACCAAGGCCGGTGGGCCGGTGCCGCGCA CCGTCGCCGAGTCCCTGGTCCTGCTGGTCGCGCCGCTGGCCCCGCACATCGCCGAGGAACTGTGGCGCAAGCTGGGCCAC AATGACTCGGTCGTCCACCAGGACTTCCCGGTCGCCGACCCGGCGTACGTCGTGGACGAGGCCGTGACCTGCGTCGTGCA GATCAAGGGCAAGGTCAAGGCACGCCTGGAGGTCTCGCCCGCCATCTCCGAGGAGGAGCTGGAGAAGGTGGCGCTGGCCG ACGAGAAGGTCGTGGCGGCACTGGGCGGCGCGGGCATCCGCAAGGTGATCGTGCGGGCGCCGAAGCTGGTGAACATCGTC ACCGCCTGA Protein sequence : MSETNPAAASEVAAPHRYTAAVAAEIEARWQDFWDAEGTYEAPNPTGDLAGGPALVAKPKKFVMDMFPYPSGAGLHVGHP LGYIATDVFARFQRMTGHNVLHTLGFDAFGLPAEQYAVQTGTHPRVSTEANIENMKVQLRRLGLGHDKRRSFATIDPDYY KWTQWIFLQIFNSWYDEEANKARPIAELVAQFESGERAVPRADGATRAWRELTAAERADVLGEYRLAYASEAPVNWSPGL GTVLANEEVTADGRSERGNFPVFKAKLRQWNMRITAYADRLLDDLDALDWPEAIKLQQRNWIGRSEGARVDFPIDGEAVT VFTTRPDTLFGATYMVLAPEHPLVEKFTPAAWPEGTHDVWTGGHATPAEAVAAYRAQAASKSDVERQAEAKDKTGVFTGA YATNPVSGEQVPVFIADYVLMGYGTGAIMAVPAHDTRDFAFARAFELSMRCVVEPSDDRGTDPSTWDDAFASYDAKIVNS SSGEISLDGLGVVEAKARITEWLERKGLGEGTVNFRLRDWLFSRQRYWGEPFPIVYDEDGIAHALPESMLPLELPEVEDY SPRTFDPDDANTSPETPLSRNEDWVNVTLDLGDGRGPQKYRRETNTMPNWAGSCWYELRYLDPHNDQKLVDPAIEQYWMG PREGQPTGGVDLYVGGAEHAVLHLLYARFWSKVLFDLGHISSAEPFHKLFNQGMIQAYVYRDSRGIAVPAAEVEERDGAY YYQGEKVSRLLGKMGKSLKNAVTPDEICAEYGADTLRLYEMAMGPLDVSRPWDTRAVVGQFRLLQRLWRNVVDEATGEVT VVDAEPDEETLRALHKAIDGVRQDLEGMRFNTAIAKVTELNNQLTKAGGPVPRTVAESLVLLVAPLAPHIAEELWRKLGH NDSVVHQDFPVADPAYVVDEAVTCVVQIKGKVKARLEVSPAISEEELEKVALADEKVVAALGGAGIRKVIVRAPKLVNIV TA |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 5e-138 | 49 |
