Gene Information

Name : clpB1 (SAV_4514)
Accession : NP_825691.1
Strain : Streptomyces avermitilis MA-4680
Genome accession: NC_003155
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 5513634 - 5516246 bp
Length : 2613 bp
Strand : +
Note : ATPases with chaperone activity, PF07724: ATPase family associated with various cellular activities (AAA)

DNA sequence :
GTGGACGCCGAGCTGACCAACAGGAGCCGGGACGCCATCAACGCGGCCACCAACAGGGCCGTGTCCGAGGGGCACCCGGA
TCTCACCCCCGCGCATTTGCTGCTGGCGCTGCTGGGGGGCAAGGACAACGAGAACATCACGGACCTGCTGGCCGCGGTCG
ACGCGGACCAGGCCGCCGTGCGCGCCGGCACCGAGCGTGTCCTGGCCAAACTGCCGAGCGTGACCGGTTCCACCGTCGCG
CCCCCGCAGCCCAACCGCGAGCTGCTCGCGGTCGTCGCCGACGCGTCGCAGAGGGCACAGGACCTCGGCGACGACTTCCT
GTCGACCGAGCATCTGCTCATCGGGATCGCCGCGAACGGCGGCGCGGCCGGCGACGTACTCTCCCAGCAGGGCGCCAGTG
CGAAAAAGCTGCTGGAGGCGTTCCAGAAGACCAGGGGAGGGCGCCGGGTGACGACCCCGGATCCCGAGGGCCAGTACAAG
GCGCTCGAAAAGTTCGGTACCGACTTCACCGCCGCCGCGCGGGACGGCAAGCTCGACCCCGTCATCGGGCGGGACCAGGA
GATCCGGCGGGTCGTGCAGGTGCTCAGCCGCCGCACCAAGAACAATCCCGTCCTCATCGGTGAGCCCGGCGTCGGCAAGA
CCGCCGTCGTCGAGGGACTCGCCCAGCGGATCGTGAAGGGCGACGTCCCGGAGTCCCTCAAGAACAAGCGGCTGGTCGCG
CTCGACCTCGGCGCCATGGTGGCCGGGGCGAAGTACCGCGGTGAGTTCGAGGAGCGGCTGAAGACCGTGCTCGCCGAGAT
CAAGGACTCCGACGGGCAGATCATCACCTTCATCGACGAGCTGCACACCGTCGTGGGGGCCGGCGCCGGCGGTGACTCCG
CGATGGACGCCGGCAACATGCTCAAGCCCATGCTCGCCCGCGGCGAGCTGCGCATGGTCGGCGCCACGACGCTCGACGAG
TACCGCGAGCGGATCGAGAAGGACCCGGCGCTGGAGCGGCGCTTCCAGCAGGTGCTCGTCGCCGAGCCCTCCGTCGAGGA
CACCATCGCGATCCTGCGCGGGCTCAAGGGGCGCTACGAGGCCCACCACAAGGTGCAGATCGCGGACAGCGCCCTGGTGG
CCGCCGCGGCGCTCTCCGACCGGTACATCACCTCCCGCTTCCTGCCCGACAAGGCCATCGACCTCGTCGACGAGGCGGCC
TCCCGCCTCCGCATGGAGATCGACTCGTCCCCGGTCGAGATCGACGAACTCCAGCGTCAGGTCGACCGGCTCAAGATGGA
GGAGCTGGCGATCGGCAAGGAGACCGACGCCGCCAGCAGGGAGCGTCTGGAGAAGCTGCGCCGCGACCTCGCCGACAAGG
AGGAGGAGCTGCGCGGACTCACCGCCCGCTGGGAGAAGGAGAAGCAGTCCCTCAACCGCGTCGGTGAGCTGAAGGAGAAG
CTCGACGAACTGCGCGGCCAGGCCGAACGCGCCCAGCGCGACGGCGACTTCGACACCGCGTCCAAGCTGCTGTACGGCGA
GATCCCGGCCCTGGAAAGGGACTTGGAGGAGGCCTCCGAGGCGGAGGAGGAAGCCGCCCGGGACACCATGGTGAAGGAGG
AGGTCGGCCCCGACGACATCGCGGACGTGGTCGGCTCCTGGACGGGCATCCCGGCCGGCCGGCTCCTCGAGGGCGAGACG
CAGAAACTCCTGCGCATGGAGGAGGAGCTGGGGCACCGGCTCATCGGGCAGTCGGAGGCCGTGCAGGCGGTGTCCGACGC
CGTACGGCGCACACGAGCCGGAATCGCCGACCCGGACCGCCCGACCGGTTCCTTCCTCTTCCTCGGCCCGACCGGTGTCG
GCAAGACCGAACTCGCCAAGGCCCTCGCCGACTTCCTCTTCGACGACGAGCGGGCCATGGTCCGCATCGACATGAGCGAG
TACGGCGAGAAGCACACCGTCGCCCGGCTGGTGGGCGCCCCGCCCGGCTATGTCGGGTACGAGGAGGGCGGCCAGCTCAC
CGAGGCCGTGCGCCGGCGTCCGTACAGCGTCGTACTCCTCGACGAGGTCGAGAAGGCGCACCCGGAGGTCTTCGACATCC
TGCTCCAGGTGCTGGACGACGGACGACTGACGGACGGCCAGGGGCGGACGGTCGACTTCCGCAACACCATCCTGATCCTC
ACCTCGAACCTGGGCAGCCAGTTCCTGAGCGGGCACGGCCCGGCCGAGCCGCAGACCTCGGAAGAGGAGAAGAAGCGGCA
GGTCCTGGAGGTCGTACGGGCCTCCTTCAAGCCGGAGTTCCTCAACCGGCTCGACGACCTGGTCGTCTTCTCGGCGCTGA
ACCGTCAGGAGCTGGAGCGCATTGCCAAGCTCCAGATCGACCGGCTGGCCCAGCGGCTCGCCCAGCGTCGGCTCCGCCTG
GAGGTCACCGACGCGGCGCTGGCCTGGCTCGCGGAGGAGGGCAACGACCCGGCGTACGGCGCCCGCCCGCTGCGCCGCCT
CGTCCAGACCGCCATCGGCGACCGCCTCGCGAAGGAGATCCTGGCGGGCGAGGTCAAGGACGGCGACACGGTACGGGTGG
ACGCCTTCGGTGAGGGCCTGATCGTGGGCCCGGCGACCGGCAAGACGCTGTAA

Protein sequence :
MDAELTNRSRDAINAATNRAVSEGHPDLTPAHLLLALLGGKDNENITDLLAAVDADQAAVRAGTERVLAKLPSVTGSTVA
PPQPNRELLAVVADASQRAQDLGDDFLSTEHLLIGIAANGGAAGDVLSQQGASAKKLLEAFQKTRGGRRVTTPDPEGQYK
ALEKFGTDFTAAARDGKLDPVIGRDQEIRRVVQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVKGDVPESLKNKRLVA
LDLGAMVAGAKYRGEFEERLKTVLAEIKDSDGQIITFIDELHTVVGAGAGGDSAMDAGNMLKPMLARGELRMVGATTLDE
YRERIEKDPALERRFQQVLVAEPSVEDTIAILRGLKGRYEAHHKVQIADSALVAAAALSDRYITSRFLPDKAIDLVDEAA
SRLRMEIDSSPVEIDELQRQVDRLKMEELAIGKETDAASRERLEKLRRDLADKEEELRGLTARWEKEKQSLNRVGELKEK
LDELRGQAERAQRDGDFDTASKLLYGEIPALERDLEEASEAEEEAARDTMVKEEVGPDDIADVVGSWTGIPAGRLLEGET
QKLLRMEEELGHRLIGQSEAVQAVSDAVRRTRAGIADPDRPTGSFLFLGPTGVGKTELAKALADFLFDDERAMVRIDMSE
YGEKHTVARLVGAPPGYVGYEEGGQLTEAVRRRPYSVVLLDEVEKAHPEVFDILLQVLDDGRLTDGQGRTVDFRNTILIL
TSNLGSQFLSGHGPAEPQTSEEEKKRQVLEVVRASFKPEFLNRLDDLVVFSALNRQELERIAKLQIDRLAQRLAQRRLRL
EVTDAALAWLAEEGNDPAYGARPLRRLVQTAIGDRLAKEILAGEVKDGDTVRVDAFGEGLIVGPATGKTL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 3e-98 43
aec27 YP_851418.1 ATPase Not tested PAI II APEC-O1 Protein 2e-93 41
aec27 AAQ96721.1 Aec27 Not tested AGI-1 Protein 1e-93 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpB1 NP_825691.1 ATP-dependent Clp protease VFG2084 Protein 2e-101 42