Gene Information

Name : thiA (SAV_4265)
Accession : NP_825442.1
Strain : Streptomyces avermitilis MA-4680
Genome accession: NC_003155
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 5231881 - 5233686 bp
Length : 1806 bp
Strand : -
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGACCAACAAGGACGCACGCACGCCTGCCTCCAGCCAGACGGGCGAGGCGCTCGCCTCGCCCCAGGGCGACCAGGAGGC
CGGGAAATCCATCGGCTGGCACAAGGCGTACGTCGCGGGTTCGCGCCCCGATCTGCGGGTGCCGGTCCGTCAGGTGCACC
TCACCAACGGGGAGTCGGTGACGCTCTACGACACCTCCGGCCCGTACACCGACCCGTCCGTCGACACCGATGTCCGCAGG
GGACTCGCGCCGCTGCGGGAGAACTGGATCATCGCCCGCGGCGACACCGAGGAGTACGCGGGCCGACCCGTTCGCCCCGA
GGACGACGGGATCAAGCACACCTCGCCGCGCGGCGGGCTGCGCAACCTGGACGCGGTGTTCCCGGGGCGGCCACGTCAGC
CGCGCCGGGGCCGTGACGGACAGGCCGTGACGCAGCTCGCGTACGCGCGCCGCGGCGAGATCACGCCCGAGATGGAGTTC
GTGGCCGTCCGGGAGAACGTCTCGGCGGAGGTCGTGCGCGAGGAGATCGCGGCCGGACGGGCCGTAATGCCCGTGAACGT
CAACCACCCGGAGATCGAGCCGATGATCATCGGCAAGCGGTTCCTGGTGAAGGTCAACGCCAACATCGGCAACTCCGCGG
TCACTTCCTCCATCGAGGAGGAGGTCGAGAAGATGACCTGGGCGACCCGCTGGGGCGCCGACACCGTCATGGACCTGTCC
ACCGGCCGCAACATCCACACCACGCGCGAATGGGTCCTGCGCAACTCCCCCGTGCCGATCGGCACGGTCCCGCTCTACCA
GGCGCTCGAGAAGGTCGACGGCAGGGCCGAGGAACTGACCTGGGAGATCTACAAGGACACGGTCATCGAACAGGCCGAGC
AGGGCGTGGACTACATGACGGTCCATGCGGGCGTGCGCCTCCCCTATGTGCCGCTCACCGCGAACCGCAAGACCGGGATC
GTCTCGCGCGGCGGCTCGATCATGGCGGCGTGGTGCCTGGCGCACCACAAGGAGAGCTTCCTGTACGAGAACTTCGAGGA
GCTCTGCGAGATCCTCGCGGCATACGACGTCACGTACTCCCTCGGCGACGGTCTGCGTCCCGGCTCGATCGCGGACGCCA
ACGACGAGGCGCAGTTCGCGGAACTCCGAACTCTGGGGGAACTCAACCGGATCGCGAAGCGTTTCAACGTACAGACCATG
ATCGAGGGCCCGGGCCACGTCCCGATGCACAAGATCAAGGAGAACATCGACCTTCAGCAGGAGATCTGCGATGAAGCTCC
TTTCTATACGCTCGGCCCACTGACGACGGACGTCGCGCCGGCGTACGACCACATCACCTCCGGCATCGGTGCCGCGATGA
TCGCCTGGTGGGGCACGGCGATGCTCTGCTACGTCACGCCCAAGGAGCACTTGGGTCTGCCCAACCGTGACGACGTCAAG
ACCGGCGTCATCACCTACAAGATCGCCGCCCATGCCGCCGACCTCGCCAAGGGGCACCCAGGCGCGCAGGAGTGGGACGA
CGCGCTGTCCGACGCCCGGTTCGAGTTCCGCTGGGAGGACCAGTTCAACCTGGCCCTCGACCCGGACACGGCACGGGAGT
TCCACGACGAGACGCTCCCGGCGGAGCCGGCCAAGACGGCCCACTTCTGCTCGATGTGCGGGCCGAAGTTCTGTTCGATG
AAGATCTCCCAGGACATCCGCCGTGAGCACGGCGGGACGCGGACGGAGGTCGAGGAAGGCATGGCACAGAAGTCCAAGGA
GTTCGCGGCGGCCGGGAACCGGGTCTATCTGCCGTTGGCGGACTGA

Protein sequence :
MTNKDARTPASSQTGEALASPQGDQEAGKSIGWHKAYVAGSRPDLRVPVRQVHLTNGESVTLYDTSGPYTDPSVDTDVRR
GLAPLRENWIIARGDTEEYAGRPVRPEDDGIKHTSPRGGLRNLDAVFPGRPRQPRRGRDGQAVTQLAYARRGEITPEMEF
VAVRENVSAEVVREEIAAGRAVMPVNVNHPEIEPMIIGKRFLVKVNANIGNSAVTSSIEEEVEKMTWATRWGADTVMDLS
TGRNIHTTREWVLRNSPVPIGTVPLYQALEKVDGRAEELTWEIYKDTVIEQAEQGVDYMTVHAGVRLPYVPLTANRKTGI
VSRGGSIMAAWCLAHHKESFLYENFEELCEILAAYDVTYSLGDGLRPGSIADANDEAQFAELRTLGELNRIAKRFNVQTM
IEGPGHVPMHKIKENIDLQQEICDEAPFYTLGPLTTDVAPAYDHITSGIGAAMIAWWGTAMLCYVTPKEHLGLPNRDDVK
TGVITYKIAAHAADLAKGHPGAQEWDDALSDARFEFRWEDQFNLALDPDTAREFHDETLPAEPAKTAHFCSMCGPKFCSM
KISQDIRREHGGTRTEVEEGMAQKSKEFAAAGNRVYLPLAD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 63
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 63
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 7e-170 59