Gene Information

Name : pykA1 (SAV_2825)
Accession : NP_824001.1
Strain : Streptomyces avermitilis MA-4680
Genome accession: NC_003155
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : -
Position : 3470703 - 3472133 bp
Length : 1431 bp
Strand : +
Note : glycolysis

DNA sequence :
ATGCGCCGTTCGAAAATCGTCTGTACTCTCGGCCCCGCGGTCGACTCCCACGAGCAGCTCGTCACGCTGATCGAGGCCGG
CATGAACGTGGCCCGCTTCAACTTCAGCCACGGCACGCACGCCGAGCACCAGGGCCGGTACGACCGGGTCCGGGCCGCGG
CCGCCGAGACCGGCAAGGCCATCGGTGTCCTCGCGGACCTCCAGGGCCCGAAGATCCGGCTGGAGACCTTCGCCGAGGGT
CCCGTCGAGCTGGTGCGCGGTGACGAGTTCATCATCACCACCGAGGACGTGCCGGGCGACAAGCACATCTGCGGCACGAC
GTACAAGGGCCTGCCCGGGGACGTCTCCAAGGGCGACCAGATCCTCATCAACGACGGCAACGTCGAGCTGCGGGTCGTCG
AGGTCGACGGGCCGCGGGTCAAGACGGTCGTCATCGAGGGCGGCGTGATCTCCGACCACAAGGGCATCAACCTGCCCGGC
GCGGCCGTGAACGTGCCCGCGCTGTCCGACAAGGACATCGAGGACCTGCGCTTCGCCCTGAAGATGGGCTGCGACCTGGT
CGCGCTGTCCTTCGTGCGCGACGCGAGCGACGTGAAGGACGTCCACAAGGTGATGGACGAGGAGGGCCGCCGGGTCCCCG
TCATCGCCAAGGTGGAGAAGCCGCAGGCGGTGGAGAACATGGAGGCCGTCGTCGCGGCCTTCGACGGCGTGATGGTGGCG
CGCGGCGACCTGGCCGTCGAGTACCCGCTCGAGAAGGTCCCGATGGTGCAGAAGCGCCTCGTGGAGCTGTGCCGCCGCAA
CGCCAAGCCGGTGATCGTCGCGACCCAGATGATGGAGTCGATGATCACCAACTCCCGCCCGACGCGCGCCGAGGCGTCCG
ACGTGGCCAACGCGATCCTCGACGGCGCGGACGCGGTGATGCTGTCCGCCGAGTCGTCGGTCGGCGCCTACCCGATCGAG
ACGGTCAAGACGATGTCGAAGATCGTCACGGCGGCGGAGGAAGAGCTGCTGTCGAAGGGCCTGCAGCCGCTGGTCCCCGG
CAAGAAGCCCCGTACGCAGGGTGGTTCGGTCGCCCGCGCGGCCTGCGAGATCGCCGACTTCCTGGGCGGCAAGGGCCTGG
TGGCCTTCACCAAGTCGGGCGACACCGCCCGTCGGCTCTCCCGCTATCGCGCGGCCCAGCCGATCCTGGCCTTCACCACG
GACGAGGGCACGCGCAACCAGCTCGCACTGAGCTGGGGCGTCGAGTCCCACGTCGTGCCGTTCGTGAACAGCACCGACGA
GATGGTCGACCTGGTCGACTCCGAGCTGCAGAACCTGAAGCGGTTCAACGACGGCGACGTCGTCGTGATGACCGCCGGCT
CGCCCCCCGGCGTCCCGGGCACGACGAACATGGTGCGAGTGCACCACCTGGGCGAGGGCAAGCGCGCCTGA

Protein sequence :
MRRSKIVCTLGPAVDSHEQLVTLIEAGMNVARFNFSHGTHAEHQGRYDRVRAAAAETGKAIGVLADLQGPKIRLETFAEG
PVELVRGDEFIITTEDVPGDKHICGTTYKGLPGDVSKGDQILINDGNVELRVVEVDGPRVKTVVIEGGVISDHKGINLPG
AAVNVPALSDKDIEDLRFALKMGCDLVALSFVRDASDVKDVHKVMDEEGRRVPVIAKVEKPQAVENMEAVVAAFDGVMVA
RGDLAVEYPLEKVPMVQKRLVELCRRNAKPVIVATQMMESMITNSRPTRAEASDVANAILDGADAVMLSAESSVGAYPIE
TVKTMSKIVTAAEEELLSKGLQPLVPGKKPRTQGGSVARAACEIADFLGGKGLVAFTKSGDTARRLSRYRAAQPILAFTT
DEGTRNQLALSWGVESHVVPFVNSTDEMVDLVDSELQNLKRFNDGDVVVMTAGSPPGVPGTTNMVRVHHLGEGKRA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 1e-78 44
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 8e-79 44
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 8e-79 44
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-78 43
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 2e-65 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykA1 NP_824001.1 pyruvate kinase VFG0479 Protein 3e-79 44