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Name : ureC (SAV_2715) Accession : NP_823891.1 Strain : Streptomyces avermitilis MA-4680 Genome accession: NC_003155 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 3330663 - 3332333 bp Length : 1671 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAATCCCTACGCATACGCCGCCACCCACGGCCCCCGGGCCGGCGACCGGGTCCGCCTCGGCGACTCGGGGCTGACGAT CCGCGTCGAGTCCGACGCCCAGCAGTACGGGGACGAGTTCCTCGCCGGGTTCGGCAAGACCGCCCGCGACGGACTGCACC TCAAGGCCGCGGCCGTCCGCGACACCTGTGACGTCGTCATCAGCAATGTCGTCGTGATCGACGCGGCGCAGGGCATCCGG AAGGTGTCCATCGGGATCCGGGAAGGCCGGATCTGCTCGATCGGACGGGCCGGGAACCCCGACACCCTCGCCGGGGTCGA CGTCGTGGTCGGCACCGGCACGTCCATCGTCTCCGGAGAGGGGCTGATCGCCACCGCCGGAGCCGTCGACACCCACGTCC ACCTGCTGTCGCCGCGCATCATGGAGGCCTCCCTCGCCTCCGGCGTGACCACGGTCATCGGCCAGGAGTTCGGGCCCGTG TGGGGCGTCGGCGTCAACTCGCCCTGGGCGCTGCGGCACGCGTTCAGCGCCTTCGACGCCTGGCCGGTCAACATCGGCTT CCTGGGCCGGGGTTCGTCGTCCGACCCGGCGCCCCTGGTCGAGGCACTCGCCGAGGGCGGCGCGTCCGGCTTCAAGGTCC ACGAGGACATGGGCGCCCACACCCGTGCCCTCGACACCGCGCTGCGCGTCGCCGAGGAGCACGATGTGCAGGTCGCCCTG CACAGCGACGGACTGAACGAGTGCCTCTCGGTCGAGGACACCCTGCGGGTCCTCGACGGGCGCACCATCCACGCCTTCCA CATCGAGGGCTGCGGCGGCGGGCACGTACCGAACGTGCTGAAGATGGCGGGCGTCCCGAACGTCATCGGCTCGTCCACCA ACCCGACCCTGCCCTTCGGCCGGGACGCGGTCGCCGAGCACTACGGGATGATCGTCTCCGTCCACGACCTCAAGCCCGAC CTGCCCGGCGACGCCGCCATGGCCCGCGACCGGATCCGGGCCGGGACCATGGGCGCCGAGGACGTGCTGCACGACCTGGG CGCGATCGGCATCACCTCGTCGGACGCGCAGGGCATGGGGCGGGCGGGCGAGACCGTGCGACGGACCTTCGCGATGGCCG GGAAGATGAAGGCCGAGTTCGGCGCCCCCGAGGACCACGACAACGCGCGCGTCCTGCGTTACCTGGCCAAGCTGACCATC AACCCCGCCCTCGCGCACGGGCTCGCCCACGAGGTCGGCTCGATCGAGGTCGGCAAGCTCGCCGACATCGTGCTGTGGCG CCCGGAGTTCTTCGGCGCCAAGCCGCAGCTCGTACTCAAGTCGGGCTTCCCCGCGTACGGGGTCGTGGGCGACCCGAACG CCGCGACCGACACCTGCGAACCCCTCGTCCTCGGGCCGCAGTTCGGGGCGCACGGGGCGACGCCCGCCGAGATCTCGGTG GCCTTCGTGGCGCAGGCGGCGCTCGACCAGGGCAACGACCGGATGCCGACCCGCCGACGGAGGGTCGCCGTGCGCGGCAC CCGCGGCATCGGCCCCGCCGACCTGCGCCTCAACTCCCGCACCGGAGCGGTCGACGTCGACCAGCGCACCGGCCTGGTCA CCCTCGACGGCGACCCGATCCGTTCCGAGCCCGCCGACTCGGTCTCCCTCAACCGCCTGTACTTCCTCTAA Protein sequence : MNPYAYAATHGPRAGDRVRLGDSGLTIRVESDAQQYGDEFLAGFGKTARDGLHLKAAAVRDTCDVVISNVVVIDAAQGIR KVSIGIREGRICSIGRAGNPDTLAGVDVVVGTGTSIVSGEGLIATAGAVDTHVHLLSPRIMEASLASGVTTVIGQEFGPV WGVGVNSPWALRHAFSAFDAWPVNIGFLGRGSSSDPAPLVEALAEGGASGFKVHEDMGAHTRALDTALRVAEEHDVQVAL HSDGLNECLSVEDTLRVLDGRTIHAFHIEGCGGGHVPNVLKMAGVPNVIGSSTNPTLPFGRDAVAEHYGMIVSVHDLKPD LPGDAAMARDRIRAGTMGAEDVLHDLGAIGITSSDAQGMGRAGETVRRTFAMAGKMKAEFGAPEDHDNARVLRYLAKLTI NPALAHGLAHEVGSIEVGKLADIVLWRPEFFGAKPQLVLKSGFPAYGVVGDPNAATDTCEPLVLGPQFGAHGATPAEISV AFVAQAALDQGNDRMPTRRRRVAVRGTRGIGPADLRLNSRTGAVDVDQRTGLVTLDGDPIRSEPADSVSLNRLYFL |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 5e-96 | 47 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 5e-96 | 47 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 7e-91 | 46 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-91 | 46 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 6e-91 | 46 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 6e-91 | 46 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | NP_823891.1 | urease subunit alpha | VFG0270 | Protein | 6e-92 | 44 |
