Gene Information

Name : clpC1 (SAV_2600)
Accession : NP_823776.1
Strain : Streptomyces avermitilis MA-4680
Genome accession: NC_003155
Putative virulence/resistance : Virulence
Product : ATP-dependent Clp protease
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 3194289 - 3196817 bp
Length : 2529 bp
Strand : +
Note : PF07724: ATPase family associated with various cellular activities (AAA)

DNA sequence :
ATGTTCGAGAGGTTCACCGACCGCGCGCGGCGCGTTGTCGTCCTGGCTCAGGAAGAAGCCCGGATGCTCAACCACAACTA
CATCGGCACCGAGCACATCCTCCTGGGCCTGATCCACGAGGGTGAGGGTGTCGCCGCCAAGGCCCTGGAGAGCCTCGGGA
TTTCGCTCGAGGCGGTCCGCCAGCAGGTGGAGGAGATCATCGGCCAGGGCCAGCAGGCCCCGTCCGGGCACATCCCCTTC
ACTCCCCGTGCCAAGAAGGTCCTGGAGCTGTCGCTCCGCGAGGCCCTTCAGCTGGGCCACAACTACATCGGCACGGAGCA
CATCCTGCTCGGCCTGATCCGTGAGGGCGAGGGTGTCGCCGCCCAGGTCCTGGTCAAGCTGGGCGCAGACCTCAACCGGG
TGCGGCAGCAGGTCATCCAGCTGCTCTCCGGTTACCACCAGGGCAAGGAGAGCACCGTCGAGGGCGGTCCTGCCGAGGGC
ACCCCCTCCACGTCCCTGGTCCTCGACCAGTTCGGCCGGAATCTCACCCAGGCCGCTCGTGAGTCCAAGCTCGACCCGGT
CATCGGGCGCGAGAAGGAGATCGAGCGGGTCATGCAGGTGCTGTCCCGCCGTACGAAGAACAACCCGGTCCTGATCGGTG
AGCCCGGTGTCGGCAAGACCGCCGTCGTCGAGGGCCTCGCTCAGGCGATCGTCAAGGGCGAGGTGCCCGAGACCCTCAAG
GACAAGCACCTCTACACCCTGGACCTGGGTGCGCTGGTCGCCGGTTCCCGCTACCGCGGTGACTTCGAGGAGCGCCTGAA
GAAGGTGCTGAAGGAGATCCGCACCCGCGGCGACATCATCCTGTTCATCGACGAGCTGCACACGCTCGTCGGTGCGGGTG
CCGCCGAGGGCGCCATCGACGCGGCTTCGATCCTGAAGCCGATGCTGGCCCGCGGTGAGCTGCAGACCATCGGCGCCACC
ACACTCGACGAGTACAAGAAGTATCTGGAGAAGGACGCGGCTCTCGAGCGGCGTTTCCAGCCGATCCAGGTGGCGGAGCC
TTCCCTCCCCCACACGATCGAGATCCTCAAGGGCCTGCGGGACCGTTACGAGGCACACCACCGTGTCTCCATCACGGACG
AGGCCCTGGTGCAGGCGGCGACGCTCGCCGACCGCTACGTCTCGGACCGCTTCCTCCCGGACAAGGCGATCGACCTGATC
GACGAGGCGGGTTCCCGGATGCGGATCCGCCGGATGACCGCGCCGCCGGACCTGCGCGAGTTCGACGAGAAGATCGCGGG
CGTGCGCCACGACAAGGAGTCCGCGATCGACTCGCAGGACTTCGAGAAAGCCGCCTCCCTTCGCGACAAGGAGAAGCAGC
TCCTGGCCGCGAAGGCCAAGCGGGAGAAGGAGTGGAAGACCGGCGACATGGACGTCGTCGCCGAGGTCGACGGCGAGCTG
ATCGCCGAAGTTCTGGCCGCGTCGACGGGCATTCCCGTCTTCAAGCTCACAGAAGAGGAGTCGAGTCGTCTCCTGCGCAT
GGAGGACGAGCTCCACAAGCGGGTCATCGGCCAGAAGGACGCCGTCAAGGCGCTGTCGAAGGCGATCCGTCGTACGCGTG
CGGGTCTGAAGGACCCGAAGCGTCCGGGTGGTTCGTTCATCTTCGCGGGCCCGTCCGGTGTCGGTAAGACCGAGCTGTCG
AGGGCCCTGGCGGAGTTCCTGTTCGGTGACGAGGACGCGCTGATCTCCCTCGACATGTCGGAGTTCAGCGAGAAGCACAC
GGTCTCGCGTCTGTTCGGTTCGCCTCCCGGTTACGTGGGCTACGAAGAGGGCGGGCAGCTGACCGAGAAGGTCCGCCGCA
AGCCGTTCTCCGTGGTCCTGTTCGACGAGGTCGAGAAGGCCCACGCGGACATCTTCAACTCGCTGCTGCAGATCCTGGAG
GACGGTCGGCTGACCGACTCCCAGGGCCGGGTCGTGGACTTCAAGAACACGGTCATCATCATGACGACCAACCTCGGCAC
CCGGGACATCTCCAAGGGCTTCAACCTGGGCTTCGCCGCCCAGGGCGACTCCAAGTCCACCTACGAGCGCATGAAGAACA
AGGTCGCGGACGAGCTCAAACGGCACTTCCGCCCCGAGTTCCTCAACCGCGTCGACGACGTGGTCGTCTTCCCGCAACTG
ACGCGGGACGACATCCTCGCGATCGTCGACCTGATGATCACCAAGGTCGACGAGCGCCTCAAGGACCGGGACATGGGCAT
CGAACTCGCCCAGTCCGCGAAGGAACTGCTCGCGCAGAAGGGCTACGACCCCATGCTCGGGGCGCGGCCGCTGCGCCGCA
CGATCCAGCGCGAGATCGAGGACACCCTCTCCGAGAAGATCCTCTTCGGGGAGCTGCGTCCGGGCCACATCGTGGTCGTC
GACACGGAGGGCGAGGGCGAGACCAAGACCTTCACCTTCCGCGGCGAGGAGAAGTCGGCCCTGCCCGACGTCCCCCCGAT
CGAACAGGCAACAGGAGGTGACCGGCCGGGCTCGGGTACGGAGTCCTGA

Protein sequence :
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYHQGKESTVEGGPAEG
TPSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLK
DKHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGAT
TLDEYKKYLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYVSDRFLPDKAIDLI
DEAGSRMRIRRMTAPPDLREFDEKIAGVRHDKESAIDSQDFEKAASLRDKEKQLLAAKAKREKEWKTGDMDVVAEVDGEL
IAEVLAASTGIPVFKLTEEESSRLLRMEDELHKRVIGQKDAVKALSKAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELS
RALAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHADIFNSLLQILE
DGRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAAQGDSKSTYERMKNKVADELKRHFRPEFLNRVDDVVVFPQL
TRDDILAIVDLMITKVDERLKDRDMGIELAQSAKELLAQKGYDPMLGARPLRRTIQREIEDTLSEKILFGELRPGHIVVV
DTEGEGETKTFTFRGEEKSALPDVPPIEQATGGDRPGSGTES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 75
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 5e-94 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
clpC1 NP_823776.1 ATP-dependent Clp protease VFG0079 Protein 0.0 61
clpC1 NP_823776.1 ATP-dependent Clp protease VFG0080 Protein 4e-153 52