Gene Information

Name : murD (YPO0553)
Accession : YP_002345624.1
Strain : Yersinia pestis CO92
Genome accession: NC_003143
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 597578 - 598894 bp
Length : 1317 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGGTTGATTATCAGGGTAAAAAAGTGGTCATCATCGGGCTGGGGCTAACCGGCCTTTCCTGCGTTGATTTCTTTATAGC
GCGTGGTGTCACGCCGCGCGTGATGGATACCCGCATCAATCCACCGGGCTTAGATCAATTACCCGAAAGTGTCGAACAGC
ATGTGGGTGATTTGAACCAAGAATGGCTACTGGACGCTGATTTAATTGTTGTTAGCCCCGGTATGGCTCTGGCACATCCT
GCATTAAGTGAAGCCGCCGAGGCCGGTGTCGAGATCATTGGCGATATCGAACTGTTCTGCCGTGAAAATCAGGCACCGGT
TGTGGCTATCACTGGCTCCAACGGCAAAAGTACCGTGACGACGCTGGTCGGTGAGATGGCAAAAGCGGCAGGTTGGTCAG
TGGGGGGCGGCGGCAATATCGGCGTTCCGGCACTGACATTGCTGAAGCAAGATAACCAATTAACTGTCTTGGAATTATCA
AGTTTCCAACTGGAAACCACCCACAGCTTGCGGGCCTCTGCTGCGACGATTCTGAACGTGACGGAAGATCATACTGACCG
TTATCCACTCGGTTTGCAGCAATACCGTGCGGCGAAACTGCGGGTGTATGAAAATGCCAAGGTTTGTGTCGTGAATGCCG
ATGATGCACTCACCATGCCGGTCCGTGGTGCTGATAGCCGTTGCATCAGTTTTGGGGTCGATGTCGGTGACTACCACCTG
AATAAGCAGCAGGGTGAAATTTGGTTACGGGTTCGTGGTGAGAAAGTGCTGAACACCCGTGAAATGAAATTAAGTGGGCG
TCATAACTATACCAATGCGCTGGCCGCCCTGGCATTAGCTGATGCCGTGGGTATCCCACGGGCATCCAGTTTGAAAGCCT
TGACGACCTTTTCCGGCTTGCCACACCGCTTCCAATTGGTGCTTGAGCGCCATGGTGTGCGCTGGATCAACGACTCCAAA
GCGACCAACGTGGGCAGCACTGAAGCCGCGCTGGATGGTTTACAGGTTGATGGCACCTTGCATTTATTGTTGGGGGGCGA
CGGTAAATCTGCTGATTTCTCCGGGTTAACGCACTTCCTGCAAGGGGATCGCATCAAGGTCTACTGTTTTGGCCGCGATG
GCGGTCAATTGGCTGCGTTGCGCCCTGACGTCTCTCAACTTACCGAGACGATGGCGCAGGCTATGGCGTTGGTGGCAAAA
GTTGTGCTACCCGGCGATAGGGTGCTGCTGTCACCTGCGTGTGCCAGCCTGGATCAATTCCGCAGCTTTGAGCATCGTGG
TAATGAGTTTGCTCGTCTGGCAGAGGAGTTAGGCTGA

Protein sequence :
MVDYQGKKVVIIGLGLTGLSCVDFFIARGVTPRVMDTRINPPGLDQLPESVEQHVGDLNQEWLLDADLIVVSPGMALAHP
ALSEAAEAGVEIIGDIELFCRENQAPVVAITGSNGKSTVTTLVGEMAKAAGWSVGGGGNIGVPALTLLKQDNQLTVLELS
SFQLETTHSLRASAATILNVTEDHTDRYPLGLQQYRAAKLRVYENAKVCVVNADDALTMPVRGADSRCISFGVDVGDYHL
NKQQGEIWLRVRGEKVLNTREMKLSGRHNYTNALAALALADAVGIPRASSLKALTTFSGLPHRFQLVLERHGVRWINDSK
ATNVGSTEAALDGLQVDGTLHLLLGGDGKSADFSGLTHFLQGDRIKVYCFGRDGGQLAALRPDVSQLTETMAQAMALVAK
VVLPGDRVLLSPACASLDQFRSFEHRGNEFARLAEELG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 3e-55 43
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 3e-55 43