Gene Information

Name : hemC (NMA0718)
Accession : YP_002342173.1
Strain : Neisseria meningitidis Z2491
Genome accession: NC_003116
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 706718 - 707653 bp
Length : 936 bp
Strand : +
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence :
ATGAACCCGAAAAAACTTGTTATCGCCAGCCGCGAAAGCCTGCTTGCTATGTGGCAGGCAAAGCATATCCAAGGCCGTCT
GAAGGCTCTGTATCCCGATTGCGAAGTCGAGATTTTGGGCATGACCACGCGCGGCGATCAGATTTTGGACAAAACTTTGT
CAAAAGTCGGCGGTAAAGGCTTGTTTGTCAAAGAGTTGGAACAGGCTTTATATGACGGGCGCGCCGATTTGGCGGTGCAT
TCGATTAAAGACGTACCGATGGATTTGCCTGAAGGTTTCGCGCTTGCGGCCATCGGCGAACGCGCCAATCCGTTTGACGC
ATTTGTGTCCAACCAATACGCGCGTTTGGAAGAAATGCCCGAAGGCGCGGTTGTCGGCACATCCAGCCTGCGCCGCGAAG
CCCAGTTGCGTGCGCGCTATCCGCATTTGCTTATCAAACCTTTGCGCGGCAATGTGCAAACCCGTTTGTCCAAACTCGAT
AACGGCGAATACGACGCAATTATCTTGGCTGCCGCCGGTTTGCAGCGTCTGAAATTGGACGGACGCATCCGCATGATTTT
GTCGGAATCCGACAGCCTGCCTGCCGCCGGACAAGGCGCATTGGGTATCGAAATTGCCGCGCACCGCGAAGATTTGTATG
AAGTTTTGAAACCCTTGAACCACGGTGTTACCAATGCCTGCGTTACCGCCGAACGCGCCCTCGCACGCGCTTTGGGCGGA
AGCTGCCAAGTGCCTTTGGCCGCATATTGCACGGAAGAAAACGGCTTGCTGACCTTGCGCGGCTTGGTCGGACACCCCGA
CGGTTCGGTTGTGTTGCGGGCGGACGCGCAAGCCCCTGCCGAATATGCCGACGCGCTCGGACGCGCTGTCGCTAAGAAAT
TGGCGGACGACGGTGCGCGGGAATTGATTGGAGCAGTATTGAATACGGAAAATTGA

Protein sequence :
MNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLFVKELEQALYDGRADLAVH
SIKDVPMDLPEGFALAAIGERANPFDAFVSNQYARLEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLD
NGEYDAIILAAAGLQRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALARALGG
SCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGARELIGAVLNTEN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 4e-70 56
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 4e-70 56