Gene Information

Name : thiC (NMA0397)
Accession : YP_002341899.1
Strain : Neisseria meningitidis Z2491
Genome accession: NC_003116
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 365773 - 367674 bp
Length : 1902 bp
Strand : +
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGACTACGCCAAAAAAAACTGCCAAAACTTCCGGCAACGAAGCGCGCGAACTTGCCGACTTGAGCGAAGACATCGGTAT
CCGCTTCAAATATCCGAACTCGGAACGCGTGTATCTGCAAGGCAGCCGCGACGACATCCGCGTGCCTTTGCGTGAAATCC
GTCAGGACGACACCTATACGGCGCAAGGCGCGGAAGCCAACCCGCCGATTCCCGTCTATGACACCAGCGGCGTGTACGGC
GACCCGGCGGCACACATCGACCTGAAACAAGGTCTGCCCCATATCCGCACGGTGTGGCTGGACGAACGCGGCGATACCGA
AATCCTGCCCAAGCTCTCCAGCGAATACGGCATCGAACGCGCACACGATCCGAAAACCGCCCATCTGCGTTTCAACCAAA
TTACCCGCCCGCGCCGCGCCAAAGCAGGACGTAACGTTACCCAGCTCCATTACGCCCGCCAAGGCATCATCACGCCGGAA
ATGGAGTTTGTCGCCATACGCGAACGTTTAAAATTAGACGAATTGTCCCAAAAACCGGAATACGCCAAGCTCTTGAAACA
GCACGCAGGGCAAAGTTTCGGCGCGAATATCCCGACCCATCCCGACCAAATCACGCCTGAATTCGTGCGCCGAGAAATTG
CCGCCGGACGCGCGATTATCCCCGCCAACATCAACCACCCCGAACTCGAACCGATGATTATCGGCCGCAACTTCCGCGTC
AAAATCAACGGCAACTTGGGCAATTCCGCCGTCACTTCCAGTCTGACCGAAGAAGTCGAAAAAATGGTGTGGTCGCTGCG
TTGGGGCGCGGACACAATTATGGACTTATCCACAGGCGCGCATATCCATGAAACGCGCGAATGGATTATCCGCAACGCGC
CCGTCCCCATCGGCACCGTGCCTATTTATCAGGCTTTGGAAAAAACCGGCGGCATTGCCGAAGATTTGACTTGGGATTTG
TTCCGCGACACCTTAATCGAGCAGGCGGAACAAGGCGTGGACTATTTCACCATACACGCGGGCGTGTTGCTGCGTTATGT
ACCGATGACCGCCAACCGCCTCACCGGCATCGTCTCGCGCGGCGGTTCGATTATGGCGAAATGGTGTTTGGCACATCATC
GGGAAAACTTCCTTTACACGCATTTCGACGAAATCTGCGAAATCATGAAAGCGTATGATGTGTCGTTCAGCCTCGGCGAC
GGCCTGCGCCCCGGCTGCATTGCCGATGCCAACGACGAATCCCAATTCGCCGAGCTGCACACCTTGGGCGAATTGACCGA
TAAAGCGTGGAAACATGACGTACAAGTCATGATCGAAGGCCCCGGCCATGTGCCGCTGCAACGCGTCAAAGAAAACATGA
CCGAAGAGCTGCAACACTGCTTTGAAGCACCTTTTTACACACTCGGCCCGCTCGTTACCGACATCGCACCCGGCTACGAC
CACATCACCTCGGGCATAGGCGCGGCCAATATCGGCTGGTACGGCACGGCGATGCTTTGTTACGTTACCCCCAAAGAACA
TTTGGGGCTGCCCGACAAAGAAGACGTGCGCACCGGCATCATCACCTACAAACTCGCCGCCCACGCCGCCGATCTCGCCA
AAGGCTGGCCGGGCGCACAATTACGTGACAACGCTCTGAGCAAGGCGCGTTTCGAGTTCCGTTGGCGCGACCAATTTCGC
TTAAGCCTCGACCCTGAACGTGCCGAAAGCTTCCACGACGAAACCCTGCCTGCCGAAGGCGCGAAAATCGCCCACTTCTG
CTCAATGTGCGGCCCCAAATTCTGCTCGATGAAAATCACGCAGGAAGTGCGCGACTACGCCGACAAGCAAAAAGCCCAAC
GGCAGGGCATGGAGGAAAAAGCGGTCGAGTTCGTCAAAAAAGGCGCGAAGATTTACAGTTGA

Protein sequence :
MTTPKKTAKTSGNEARELADLSEDIGIRFKYPNSERVYLQGSRDDIRVPLREIRQDDTYTAQGAEANPPIPVYDTSGVYG
DPAAHIDLKQGLPHIRTVWLDERGDTEILPKLSSEYGIERAHDPKTAHLRFNQITRPRRAKAGRNVTQLHYARQGIITPE
MEFVAIRERLKLDELSQKPEYAKLLKQHAGQSFGANIPTHPDQITPEFVRREIAAGRAIIPANINHPELEPMIIGRNFRV
KINGNLGNSAVTSSLTEEVEKMVWSLRWGADTIMDLSTGAHIHETREWIIRNAPVPIGTVPIYQALEKTGGIAEDLTWDL
FRDTLIEQAEQGVDYFTIHAGVLLRYVPMTANRLTGIVSRGGSIMAKWCLAHHRENFLYTHFDEICEIMKAYDVSFSLGD
GLRPGCIADANDESQFAELHTLGELTDKAWKHDVQVMIEGPGHVPLQRVKENMTEELQHCFEAPFYTLGPLVTDIAPGYD
HITSGIGAANIGWYGTAMLCYVTPKEHLGLPDKEDVRTGIITYKLAAHAADLAKGWPGAQLRDNALSKARFEFRWRDQFR
LSLDPERAESFHDETLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYADKQKAQRQGMEEKAVEFVKKGAKIYS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 0.0 99
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 72
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 72