Gene Information

Name : lpdA3 (NMA1151)
Accession : YP_002342552.1
Strain : Neisseria meningitidis Z2491
Genome accession: NC_003116
Putative virulence/resistance : Unknown
Product : dihydrolipoamide dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.8.1.4
Position : 1101979 - 1103412 bp
Length : 1434 bp
Strand : +
Note : E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide

DNA sequence :
ATGTCTCAATATGATGTAGTAGTGATTGGTGCAGGCCCGGGCGGATACGTTGCCGCCATCCGTGCCGCACAACTGGGTTT
CAAAACTGCCTGTGTCGATGCAGGCGTTAACAAAGCAGGCAATGCCCCTGCATTGGGCGGTACTTGCTTGAACGTAGGTT
GTATCCCTTCTAAAGCCCTGTTGCAATCCAGCGAACATTTCCACGCAGCGCAACACGAGTTTGCCGAACACGGTATCACT
GTCGGCGACGTAAAATTCGACGTGGCCAAAATGATTGAGCGCAAAGATGCCATCGTAACCAAACTGACCGGCGGCGTGAA
ATTCCTGTTCCAGAAAAACAAAGTAACCAGCCTGTTCGGTACGGCTTCCTTTGCCGGCAAAAATGGCGATGCTTACCAAA
TCGAAGTCGATAACAAAGGTGAGAAAACCGTTATCGAAGCCAAACACGTCATCGTAGCGACCGGTTCCGTACCGCGTCCG
TTGCCGCAAGTCGCTATCGACAATGTGAACGTATTGGACAACGAAGGCGCATTGAACCTGACCGAAGTACCTGCCAAACT
CGGCGTGATCGGTTCCGGTGTGATTGGTTTGGAAATGGGTTCCGTATGGAACCGCGTGGGTGCGGAAGTTACCATTCTTG
AAGCCGCGCCGACCTTCCTGGCTGCCGCCGACCAACAAATCGCCAAAGAAGCCTTCAAATACTTCACCAAAGAGCAAGGT
CTGAGCATCGAATTGGGCGTGAAAATCGGCGACATCAAGTCTGAAGGCAAAGGTGTTTCCGTTGCTTACGAAACTGCTGC
CGGCGAAGCCAAAACCGAAGTATTCGACAAACTGATCGTTGCCATCGGCCGTATTCCAAACACCAAAGGCCTGAACGCGG
AAGCCGTAGGCTTGGAAAAAGACGAGCGCGGCTTTATCAAAGTAGATGGCGAATGCCGTACCAACCTGCCTAACGTATGG
GCAATCGGCGACGTGGTTCGCGGCCCGATGTTGGCACACAAAGCCAGCGACGAAGGCGTTGCCGTTGCCGAACGCATTGC
CGGTCAAAAACCGCATATCGACTTCAACAACGTACCGTTCGTGATTTACACCGATCCTGAAATCGCTTGGGTGGGTAAAA
CCGAAGAGCAGCTCAAAGCCGAAGGCGTGGAGTACAAAAAAGGTACTTCAGGTTTTGGTGCGAATGGTCGCGCATTGGCA
ATGGGCAAAGCCAAAGGTACGGTTAAAGTGTTGGCAGACGCCAAAACCGACCGCATCTTGGGCGTACACATGATTGGTCC
GGTTGTCAGCGAATTGCTTACCGAAGGCGTGACTGCGCTCGAATTCTTCGCCAGCAGCGAAGACATCGCCCGCATTATCC
ATGCCCACCCAACCTTGTCCGAAGTGGTTCACGAAGCTGCATTGGCGGCCGACAAACGCGCTTTGCACGGTTGA

Protein sequence :
MSQYDVVVIGAGPGGYVAAIRAAQLGFKTACVDAGVNKAGNAPALGGTCLNVGCIPSKALLQSSEHFHAAQHEFAEHGIT
VGDVKFDVAKMIERKDAIVTKLTGGVKFLFQKNKVTSLFGTASFAGKNGDAYQIEVDNKGEKTVIEAKHVIVATGSVPRP
LPQVAIDNVNVLDNEGALNLTEVPAKLGVIGSGVIGLEMGSVWNRVGAEVTILEAAPTFLAAADQQIAKEAFKYFTKEQG
LSIELGVKIGDIKSEGKGVSVAYETAAGEAKTEVFDKLIVAIGRIPNTKGLNAEAVGLEKDERGFIKVDGECRTNLPNVW
AIGDVVRGPMLAHKASDEGVAVAERIAGQKPHIDFNNVPFVIYTDPEIAWVGKTEEQLKAEGVEYKKGTSGFGANGRALA
MGKAKGTVKVLADAKTDRILGVHMIGPVVSELLTEGVTALEFFASSEDIARIIHAHPTLSEVVHEAALAADKRALHG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0077 NP_763632.1 dihydrolipoamide dehydrogenase component of pyruvate dehydrogenase E3 Not tested SCCpbp4 Protein 4e-65 42