Gene Information

Name : kdsB (NMB0675)
Accession : NP_273717.1
Strain : Neisseria meningitidis MC58
Genome accession: NC_003112
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 703265 - 704026 bp
Length : 762 bp
Strand : +
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence : 
ATGACCGAATTCGTCGTATTGATTCCGGCGCGGCTGGATTCGTCGCGCCTGCCCGGAAAAGCCTTGGCGGACATCCACGG
CAAACCGATGGTCGTGCGCGTTGCCGAACAGGCGGCAAAAAGTAAAGCCGCGCGCGTCGTCGTTGCCACCGACCATCCCG
ATATTCAGACGGCCTGTCAGGCGCACGGTATCGAAGTCGTCATGACTTCAAACCGGCACGAAAGCGGCACGACGCGCCTT
GCCGAAGCCTCTGTCGCGCTGAAGCTGCCGCCGCATTTGATTGTTGTGAACGTACAGGGTGACGAGCCGCTGATTGCCCC
CGAACTCATCGACCGCACCGCCGAAGTACTCGTCGAAAACAACGTCCAAATGGCGACCGCCGCCCACGAATTGCACGATT
TCGACGAATTGATGAATCCCAACGCCGTCAAAGTCGTCCTCGACAAAAACCGCAACGCCATCTACTTCAGCCGCGCCCCG
ATTCCCTATCCGCGTGATGCGATACGTGCCGGAAAACGCGAAATGCCGTCTGAAACCGCCGTCCTGCGACATATCGGCAT
CTACGCTTACCGCGCCGGCTTCCTGCAACGCTATGCCGAAATGAGCGTTTCGCCGCTGGAAACCATCGAATCGCTGGAAC
AGCTGCGCGTCCTGTGGCACGGTTATCCCATTGCCGTCGAAACCGCCAAAGAAGCCCCCGCCGCCGGTGTGGATACGCAA
GAGGACTTGGACAGGGTTCGCGCCGTATTTCAGACCGTATAA

Protein sequence : 
MTEFVVLIPARLDSSRLPGKALADIHGKPMVVRVAEQAAKSKAARVVVATDHPDIQTACQAHGIEVVMTSNRHESGTTRL
AEASVALKLPPHLIVVNVQGDEPLIAPELIDRTAEVLVENNVQMATAAHELHDFDELMNPNAVKVVLDKNRNAIYFSRAP
IPYPRDAIRAGKREMPSETAVLRHIGIYAYRAGFLQRYAEMSVSPLETIESLEQLRVLWHGYPIAVETAKEAPAAGVDTQ
EDLDRVRAVFQTV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 3e-31 44
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 2e-31 44
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 6e-32 44