Gene Information

Name : hemC (NMB0539)
Accession : NP_273584.1
Strain : Neisseria meningitidis MC58
Genome accession: NC_003112
Putative virulence/resistance : Unknown
Product : porphobilinogen deaminase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0181
EC number : 2.5.1.61
Position : 560482 - 561417 bp
Length : 936 bp
Strand : +
Note : transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis

DNA sequence :
ATGAACCCGAAAAAACTCGTCATCGCCAGCCGCGAAAGCCTGCTTGCTATGTGGCAGGCAAAGCATATCCAAGGCCGTCT
GAAGGCTCTGTATCCCGATTGCGAAGTCGAGATTTTGGGCATGACCACGCGCGGCGATCAGATTTTGGACAAAACTTTGT
CAAAAGTCGGCGGTAAAGGCTTGTTTGTCAAAGAGTTGGAACAGGCTTTATATGACGGGCGCGCCGATTTGGCGGTGCAT
TCGATTAAGGACGTGCCGATGGATTTGCCTGAAGGTTTCGCGCTTGCCGCCATCGGCGAACGCGCCAATCCGTTTGACGC
GTTTGTGTCCAACCAATACACGCGTTTGGAAGAAATGCCCGAAGGCGCGGTTGTCGGCACATCCAGCCTGCGCCGCGAAG
CCCAGTTGCGTGCGCGCTATCCGCATTTGCTTATCAAACCTTTGCGCGGCAATGTGCAAACCCGTTTGTCCAAACTCGAT
AACGGCGAATACGACGCAATTATCTTGGCTGCCGCCGGTTTGCAGCGTCTGAAATTGGACGGACGCATCCGCATGATTTT
GTCGGAATCCGACAGCCTGCCTGCCGCCGGACAAGGCGCATTGGGTATCGAAATTGCCGCGCACCGCGAAGATTTGTATG
AAGTTTTGAAACCCTTGAACCACGGTGTTACCAATGCCTGCGTTACCGCCGAACGCGCCCTCGCACGCGCTTTGGGCGGA
AGCTGCCAAGTGCCTTTGGCCGCATATTGCACGGAAGAAAACGGCTTGCTGACCTTGCGCGGCTTGGTCGGACACCCCGA
CGGTTCGGTTGTGTTGCGGGCGGACGCGCAAGCCCCTGCCGAATATGCCGACGCGCTCGGACGCGCTGTCGCTAAGAAAT
TGGCGGACGACGGTGCGCGGGAATTGATTGGAGCAGTATTGAATACGGAAAATTGA

Protein sequence :
MNPKKLVIASRESLLAMWQAKHIQGRLKALYPDCEVEILGMTTRGDQILDKTLSKVGGKGLFVKELEQALYDGRADLAVH
SIKDVPMDLPEGFALAAIGERANPFDAFVSNQYTRLEEMPEGAVVGTSSLRREAQLRARYPHLLIKPLRGNVQTRLSKLD
NGEYDAIILAAAGLQRLKLDGRIRMILSESDSLPAAGQGALGIEIAAHREDLYEVLKPLNHGVTNACVTAERALARALGG
SCQVPLAAYCTEENGLLTLRGLVGHPDGSVVLRADAQAPAEYADALGRAVAKKLADDGARELIGAVLNTEN

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB0868_00331 YP_008211657.1 Porphobilinogen deaminase Not tested AbaR26 Protein 4e-70 56
BJAB07104_00327 YP_008207792.1 Porphobilinogen deaminase Not tested AbaR25 Protein 4e-70 56