Gene Information

Name : murD (NMB0420)
Accession : NP_273468.1
Strain : Neisseria meningitidis MC58
Genome accession: NC_003112
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 428553 - 429890 bp
Length : 1338 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGACTTTTCAAAACAAAAAAATCCTCGTCGCCGGACTCGGCGGTACGGGTATTTCCATGATTGCCTACCTGCGCAAAAA
CGGCGCGGAGGTTGCTGCGTATGATGCGGAGCTGAAGCCGGAACGCGTGTCGCAAATCGGTAAGATGTTTGACGGGTTGG
TGTTTTACACGGGCCGTCTGAAAGATGCGCTGGACAACGGTTTCGATATTCTGGCTCTCAGTCCCGGCATCAGCGAGCGG
CAGCCGGATATTGAGGCGTTCAAGCAAAACGGCGGACGCGTGTTGGGCGACATCGAATTGCTGGCGGACATTGTGAACCG
CCGGGACGACAAGGTAATTGCGATTACCGGCAGCAACGGCAAAACCACGGTAACGAGCCTGGTCGGCTATCTCTGTATCA
AGTGCGGGCTGGATACCGTTATCGCGGGCAATATCGGCACGCCGGTTTTGGAGGCGGAATGGCAGCGCGAAGGCAAAAAG
GCGGACGTGTGGGTGTTGGAGCTTTCCAGCTTCCAACTGGAAAACACCGAAAGCCTGCGTCCGACTGCGGCGACGGTGCT
GAACATTTCCGAAGACCATCTCGACCGCTACGACGACTTGCTCGACTATGCGCATACCAAAGCCAAGATTTTCCGTGGCG
ACGGCGTGCAGGTTTTGAATGCGGACGATGCGTTCTGCCGCGCGATGAAGCGTGCCGGGCGCGAGGTAAAATGGTTTTCG
TTGGAACACGAAGCTGATTTCTGGTTGGAACGCGAGACAGGCCGCCTGAAACAAGGCAATGAAGATTTGATTGTCACGCA
AGACATTCCGTTGCAAGGTCTGCACAACGCCGCTAACGTCATGGCTGCCGTGGCTTTGTGTGAGGCCATCGGTTTGTCGC
GCGAAGCATTGCTCGAACACGTCAAAACCTTCCAAGGCCTGCCGCACCGCGTGGAAAAAATCGGCGAGAAAAACGGCGTG
GTGTTTATCGACGACAGCAAAGGCACGAATGTCGGCGCGACTGCCGCCGCGATTGCCGGTTTGCAAAATCCGCTCTTCGT
GATTTTGGGCGGCATGGGTAAAGGGCAGGACTTCACGCCCCTGCGCGATGCACTGGTAGGCAAGGCAAAAGGCGTGTTCT
TGATTGGTGTCGATGCGCCGCAAATCCGCCGCGATTTGGACGGCTGCGGCTTGAATATGACCGACTGCGCCACTTTGGGA
GAAGCCGTTCAGACGGCATATGCCCAAGCCGAAGCAGGCGATATTGTGTTGCTCAGCCCCGCCTGCGCGAGCTTTGATAT
GTTCAAAGGCTACGCGCACCGTTCGGAAGTGTTTATCGAAGCGTTTAAGGCTTTGTGA

Protein sequence :
MTFQNKKILVAGLGGTGISMIAYLRKNGAEVAAYDAELKPERVSQIGKMFDGLVFYTGRLKDALDNGFDILALSPGISER
QPDIEAFKQNGGRVLGDIELLADIVNRRDDKVIAITGSNGKTTVTSLVGYLCIKCGLDTVIAGNIGTPVLEAEWQREGKK
ADVWVLELSSFQLENTESLRPTAATVLNISEDHLDRYDDLLDYAHTKAKIFRGDGVQVLNADDAFCRAMKRAGREVKWFS
LEHEADFWLERETGRLKQGNEDLIVTQDIPLQGLHNAANVMAAVALCEAIGLSREALLEHVKTFQGLPHRVEKIGEKNGV
VFIDDSKGTNVGATAAAIAGLQNPLFVILGGMGKGQDFTPLRDALVGKAKGVFLIGVDAPQIRRDLDGCGLNMTDCATLG
EAVQTAYAQAEAGDIVLLSPACASFDMFKGYAHRSEVFIEAFKAL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 1e-56 42
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 1e-56 42