Gene Information

Name : folA (NMB0308)
Accession : NP_273358.1
Strain : Neisseria meningitidis MC58
Genome accession: NC_003112
Putative virulence/resistance : Resistance
Product : dihydrofolate reductase
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0262
EC number : 1.5.1.3
Position : 317533 - 318021 bp
Length : 489 bp
Strand : +
Note : identified by similarity to EGAD:8105; match to protein family HMM PF00186

DNA sequence :
ATGCTCAAAATAACCCTAATTGCGGCGTGTGCGGAAAACCTGTGCATCGGGGCGGGCAATGCTATGCCTTGGCACATCCC
CGAAGATTTCGCATTTTTCAAAGCCTATACCTTGGGCAAACCCGTCATTATGGGGCGGAAAACGTGGGAATCCCTGCCCG
TCAAACCCCTGCCCGGACGGAGGAACATCGTCATCAGCCGGCAGGCGGATTATTGCGCGGCAGGCGCGGAAACGGCGGCA
AGTTTGGAGGCGGCATTGGCATTGTGCGCAGGCGCGGAAGAAGCCGTCATTATGGGCGGCGCGCAGATATACGGACAAGC
GATGCCATTGGCGACCGATTTGCGGATAACCGAAGTGGATTTGTCTGTGGAAGGAGATGCATTTTTCCCCGCAATAGACC
GGACGCATTGGAAAGAAGCAGAGCGGACGGAACGCCGTGTCAGCAGCAAAGGCACGCGCTATGCTTTTGTGCATTATTTG
AGATATTGA

Protein sequence :
MLKITLIAACAENLCIGAGNAMPWHIPEDFAFFKAYTLGKPVIMGRKTWESLPVKPLPGRRNIVISRQADYCAAGAETAA
SLEAALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSVEGDAFFPAIDRTHWKEAERTERRVSSKGTRYAFVHYL
RY

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dfrA12 ACF06156.1 dihydrofolate reductase Not tested Tn5036-like Protein 1e-15 44