Gene Information

Name : thiC (NMB2040)
Accession : NP_275031.1
Strain : Neisseria meningitidis MC58
Genome accession: NC_003112
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 2159620 - 2161521 bp
Length : 1902 bp
Strand : -
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGACTACGCCAAAAAAAACCGCCAAAACTTCCGGCAACGAAGCGCGCGAGCTTGCCGACTTGAGCGAAGACATCGGCAT
CTGCTTTAAATATCCGAACTCGGAACGCGTGTATCTGCAAGGCAGCCGCGACGACATCCGCGTGCCTTTGCGCGAAATCC
GTCAGGACGACACCTACACGGCGCAAGGTACGGAAGCCAATCCGCCGATTCCCGTCTACGACACCAGCGGCGTGTACGGC
GACCCGGCGGCGCATATCGACCTGAAACAAGGTCTGCCGCACATCCGCACCGCGTGGCTGGACGAACGCGGCGATACCGA
AATCCTGCCCAAGCTCTCCAGCGAATACGGCATCGAACGCGCACACGATCCGAAAACCGCCCATCTGCGTTTCAACCAAA
TCACCCGCCCGCGCCGCGCGAAAAGCGGCAGCAACGTAACCCAGCTTCACTACGCGCGCCAAGGCATTATCACGCCCGAA
ATGGAGTTTGTCGCCATACGCGAACGTTTAAAATTAGACGAATTGTCCCAAAAACCGGAATACGCCAAACTCTTGGAACA
GCACGCGGGGCAAAGTTTCGGTGCGAACATCCCGACCCATCCCGACCAAATCACGCCCGAATTCGTGCGCCAAGAAATCG
CCGCCGGACGCGCGATTATTCCCGCCAACATCAACCACCCCGAACTCGAACCGATGATTATCGGCCGCAACTTTCGTGTC
AAAATCAACGGCAACTTGGGCAACTCCGCCGTCACCTCCAGCCTGACCGAAGAAGTCGAAAAAATGGTGTGGTCGCTGCG
TTGGGGCGCGGACACGATTATGGATTTGTCCACCGGCGCGCACATCCATGAAACGCGCGAATGGATTATCCGCAACGCGC
CCGTCCCCATCGGCACCGTGCCGATTTACCAAGCGTTGGAAAAAACCGGCGGCATCGCCGAAGATTTGACTTGGGATTTG
TTCCGCGACACCCTCATCGAACAGGCGGAGCAAGGCGTGGACTATTTCACCATACACGCGGGCGTGTTGCTGCGTTATGT
GCCGATGACCGCCAACCGCCTCACCGGCATCGTCTCGCGCGGCGGTTCGATTATGGCGAAATGGTGTTTGGCACATCATC
GGGAAAATTTCCTCTACACGCATTTCGACGAAATCTGCGAAATTATGAAAGCGTATGACGTATCGTTCAGCCTCGGCGAC
GGCCTGCGCCCCGGCTGCATTGCCGATGCCAACGACGAATCCCAATTCGCCGAACTGCACACCTTGGGCGAATTGACCGA
TAAAGCGTGGAAACATGACGTACAAGTCATGATCGAAGGCCCCGGCCATGTGCCGCTGCAACGCGTCAAAGAAAACATGA
CCGAAGAGCTGCAACACTGCTTTGAAGCACCTTTTTACACGCTCGGCCCGCTCGTTACCGACATCGCACCCGGCTACGAC
CACATCACCTCGGGCATAGGCGCGGCCAATATCGGCTGGTACGGCACGGCGATGCTTTGTTACGTTACCCCGAAAGAGCA
TTTGGGGCTGCCCGACAAAGAAGACGTGCGCACCGGCATCATCACCTACAAACTCGCCGCCCACGCCGCCGATCTCGCCA
AAGGCTGGCCGGGCGCACAATTACGTGACAACGCCCTGAGCAAAGCGCGTTTCGAGTTCCGCTGGCGCGACCAATTTCGC
TTAAGCCTCGACCCTGAACGTGCCGAGAGCTTCCACGACGAAACCCTGCCTGCCGAAGGCGCGAAAATCGCCCACTTCTG
CTCGATGTGCGGCCCCAAATTCTGCTCGATGAAAATCACGCAGGAAGTGCGCGACTACGCCGACAAGCAAAAAGCCCAAC
GGCAGGGCATGGAGGAAAAAGCGGTCGAGTTCGTCAAAAAAGGCGCGAAGATTTACAGTTAA

Protein sequence :
MTTPKKTAKTSGNEARELADLSEDIGICFKYPNSERVYLQGSRDDIRVPLREIRQDDTYTAQGTEANPPIPVYDTSGVYG
DPAAHIDLKQGLPHIRTAWLDERGDTEILPKLSSEYGIERAHDPKTAHLRFNQITRPRRAKSGSNVTQLHYARQGIITPE
MEFVAIRERLKLDELSQKPEYAKLLEQHAGQSFGANIPTHPDQITPEFVRQEIAAGRAIIPANINHPELEPMIIGRNFRV
KINGNLGNSAVTSSLTEEVEKMVWSLRWGADTIMDLSTGAHIHETREWIIRNAPVPIGTVPIYQALEKTGGIAEDLTWDL
FRDTLIEQAEQGVDYFTIHAGVLLRYVPMTANRLTGIVSRGGSIMAKWCLAHHRENFLYTHFDEICEIMKAYDVSFSLGD
GLRPGCIADANDESQFAELHTLGELTDKAWKHDVQVMIEGPGHVPLQRVKENMTEELQHCFEAPFYTLGPLVTDIAPGYD
HITSGIGAANIGWYGTAMLCYVTPKEHLGLPDKEDVRTGIITYKLAAHAADLAKGWPGAQLRDNALSKARFEFRWRDQFR
LSLDPERAESFHDETLPAEGAKIAHFCSMCGPKFCSMKITQEVRDYADKQKAQRQGMEEKAVEFVKKGAKIYS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 0.0 99
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 72
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 72